Therapeutic gas‐releasing nanomedicines with controlled release: Advances and perspectives
Abstract Nanoparticle‐based drug delivery has become one of the most popular approaches for maximising drug therapeutic potentials. With the notable improvements, a greater challenge hinges on the formulation of gasotransmitters with unique challenges that are not met in liquid and solid active ingr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-10-01
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| Series: | Exploration |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/EXP.20210181 |
| _version_ | 1798029301351710720 |
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| author | Yaw Opoku‐Damoah Run Zhang Hang T. Ta Zhi Ping Xu |
| author_facet | Yaw Opoku‐Damoah Run Zhang Hang T. Ta Zhi Ping Xu |
| author_sort | Yaw Opoku‐Damoah |
| collection | DOAJ |
| description | Abstract Nanoparticle‐based drug delivery has become one of the most popular approaches for maximising drug therapeutic potentials. With the notable improvements, a greater challenge hinges on the formulation of gasotransmitters with unique challenges that are not met in liquid and solid active ingredients. Gas molecules upon release from formulations for therapeutic purposes have not really been discussed extensively. Herein, we take a critical look at four key gasotransmitters, that is, carbon monoxide (CO), nitric oxide (NO), hydrogen sulphide (H2S) and sulphur dioxide (SO2), their possible modification into prodrugs known as gas‐releasing molecules (GRMs), and their release from GRMs. Different nanosystems and their mediatory roles for efficient shuttling, targeting and release of these therapeutic gases are also reviewed extensively. This review thoroughly looks at the diverse ways in which these GRM prodrugs in delivery nanosystems are designed to respond to intrinsic and extrinsic stimuli for sustained release. In this review, we seek to provide a succinct summary for the development of therapeutic gases into potent prodrugs that can be adapted in nanomedicine for potential clinical use. |
| first_indexed | 2024-04-11T19:23:06Z |
| format | Article |
| id | doaj.art-569e2539e99e4340b891756e9eae8a88 |
| institution | Directory Open Access Journal |
| issn | 2766-8509 2766-2098 |
| language | English |
| last_indexed | 2024-04-11T19:23:06Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Exploration |
| spelling | doaj.art-569e2539e99e4340b891756e9eae8a882022-12-22T04:07:15ZengWileyExploration2766-85092766-20982022-10-0125n/an/a10.1002/EXP.20210181Therapeutic gas‐releasing nanomedicines with controlled release: Advances and perspectivesYaw Opoku‐Damoah0Run Zhang1Hang T. Ta2Zhi Ping Xu3Australian Institute for Bioengineering and Nanotechnology The University of Queensland Brisbane Queensland AustraliaAustralian Institute for Bioengineering and Nanotechnology The University of Queensland Brisbane Queensland AustraliaAustralian Institute for Bioengineering and Nanotechnology The University of Queensland Brisbane Queensland AustraliaAustralian Institute for Bioengineering and Nanotechnology The University of Queensland Brisbane Queensland AustraliaAbstract Nanoparticle‐based drug delivery has become one of the most popular approaches for maximising drug therapeutic potentials. With the notable improvements, a greater challenge hinges on the formulation of gasotransmitters with unique challenges that are not met in liquid and solid active ingredients. Gas molecules upon release from formulations for therapeutic purposes have not really been discussed extensively. Herein, we take a critical look at four key gasotransmitters, that is, carbon monoxide (CO), nitric oxide (NO), hydrogen sulphide (H2S) and sulphur dioxide (SO2), their possible modification into prodrugs known as gas‐releasing molecules (GRMs), and their release from GRMs. Different nanosystems and their mediatory roles for efficient shuttling, targeting and release of these therapeutic gases are also reviewed extensively. This review thoroughly looks at the diverse ways in which these GRM prodrugs in delivery nanosystems are designed to respond to intrinsic and extrinsic stimuli for sustained release. In this review, we seek to provide a succinct summary for the development of therapeutic gases into potent prodrugs that can be adapted in nanomedicine for potential clinical use.https://doi.org/10.1002/EXP.20210181gas‐releasing moleculesgas‐releasing nanomedicinesnanoparticle delivery systemsstimulus‐triggered gas releasetherapeutic gases |
| spellingShingle | Yaw Opoku‐Damoah Run Zhang Hang T. Ta Zhi Ping Xu Therapeutic gas‐releasing nanomedicines with controlled release: Advances and perspectives Exploration gas‐releasing molecules gas‐releasing nanomedicines nanoparticle delivery systems stimulus‐triggered gas release therapeutic gases |
| title | Therapeutic gas‐releasing nanomedicines with controlled release: Advances and perspectives |
| title_full | Therapeutic gas‐releasing nanomedicines with controlled release: Advances and perspectives |
| title_fullStr | Therapeutic gas‐releasing nanomedicines with controlled release: Advances and perspectives |
| title_full_unstemmed | Therapeutic gas‐releasing nanomedicines with controlled release: Advances and perspectives |
| title_short | Therapeutic gas‐releasing nanomedicines with controlled release: Advances and perspectives |
| title_sort | therapeutic gas releasing nanomedicines with controlled release advances and perspectives |
| topic | gas‐releasing molecules gas‐releasing nanomedicines nanoparticle delivery systems stimulus‐triggered gas release therapeutic gases |
| url | https://doi.org/10.1002/EXP.20210181 |
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