Telomere Homeostasis: Interplay with Magnesium
Telomere biology, a key component of the hallmarks of ageing, offers insight into dysregulation of normative ageing processes that accompany age-related diseases such as cancer. Telomere homeostasis is tightly linked to cellular metabolism, and in particular with mitochondrial physiology, which is a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/19/1/157 |
| _version_ | 1811229228275859456 |
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| author | Donogh Maguire Ognian Neytchev Dinesh Talwar Donald McMillan Paul G. Shiels |
| author_facet | Donogh Maguire Ognian Neytchev Dinesh Talwar Donald McMillan Paul G. Shiels |
| author_sort | Donogh Maguire |
| collection | DOAJ |
| description | Telomere biology, a key component of the hallmarks of ageing, offers insight into dysregulation of normative ageing processes that accompany age-related diseases such as cancer. Telomere homeostasis is tightly linked to cellular metabolism, and in particular with mitochondrial physiology, which is also diminished during cellular senescence and normative physiological ageing. Inherent in the biochemistry of these processes is the role of magnesium, one of the main cellular ions and an essential cofactor in all reactions that use ATP. Magnesium plays an important role in many of the processes involved in regulating telomere structure, integrity and function. This review explores the mechanisms that maintain telomere structure and function, their influence on circadian rhythms and their impact on health and age-related disease. The pervasive role of magnesium in telomere homeostasis is also highlighted. |
| first_indexed | 2024-04-12T10:11:01Z |
| format | Article |
| id | doaj.art-569ea1032420408b936f4637a95170ff |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T10:11:01Z |
| publishDate | 2018-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-569ea1032420408b936f4637a95170ff2022-12-22T03:37:18ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-01-0119115710.3390/ijms19010157ijms19010157Telomere Homeostasis: Interplay with MagnesiumDonogh Maguire0Ognian Neytchev1Dinesh Talwar2Donald McMillan3Paul G. Shiels4Emergency Medicine Department, Glasgow Royal Infirmary, Glasgow G4 0SF, UKSection of Epigenetics, Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UKThe Scottish Trace Element and Micronutrient Reference Laboratory, Department of Biochemistry, Royal Infirmary, Glasgow G31 2ER, UKAcademic Unit of Surgery, School of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow G4 0SF, UKSection of Epigenetics, Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UKTelomere biology, a key component of the hallmarks of ageing, offers insight into dysregulation of normative ageing processes that accompany age-related diseases such as cancer. Telomere homeostasis is tightly linked to cellular metabolism, and in particular with mitochondrial physiology, which is also diminished during cellular senescence and normative physiological ageing. Inherent in the biochemistry of these processes is the role of magnesium, one of the main cellular ions and an essential cofactor in all reactions that use ATP. Magnesium plays an important role in many of the processes involved in regulating telomere structure, integrity and function. This review explores the mechanisms that maintain telomere structure and function, their influence on circadian rhythms and their impact on health and age-related disease. The pervasive role of magnesium in telomere homeostasis is also highlighted.http://www.mdpi.com/1422-0067/19/1/157telomerestelomeraseTERTmitochondriaoxidative stressmagnesium |
| spellingShingle | Donogh Maguire Ognian Neytchev Dinesh Talwar Donald McMillan Paul G. Shiels Telomere Homeostasis: Interplay with Magnesium International Journal of Molecular Sciences telomeres telomerase TERT mitochondria oxidative stress magnesium |
| title | Telomere Homeostasis: Interplay with Magnesium |
| title_full | Telomere Homeostasis: Interplay with Magnesium |
| title_fullStr | Telomere Homeostasis: Interplay with Magnesium |
| title_full_unstemmed | Telomere Homeostasis: Interplay with Magnesium |
| title_short | Telomere Homeostasis: Interplay with Magnesium |
| title_sort | telomere homeostasis interplay with magnesium |
| topic | telomeres telomerase TERT mitochondria oxidative stress magnesium |
| url | http://www.mdpi.com/1422-0067/19/1/157 |
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