Novel trace elements detected in multiple stages of pregnancy impact neonatal birth weight by affecting gestational age
Prenatal exposure to elements may be associated with birth weight via shortening of gestation. This study aimed to determine if prenatal exposure is associated with birth weight, and to explore the potential mediating role of gestational age in the association. Within an established Bangladesh prosp...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S014765132201315X |
| _version_ | 1797961274782384128 |
|---|---|
| author | Liangmin Wei Xin Chen Hui Huang Ruyang Zhang Sipeng Shen Weiwei Duan Li Su Hao Yu David C. Christiani Yongyue Wei Feng Chen |
| author_facet | Liangmin Wei Xin Chen Hui Huang Ruyang Zhang Sipeng Shen Weiwei Duan Li Su Hao Yu David C. Christiani Yongyue Wei Feng Chen |
| author_sort | Liangmin Wei |
| collection | DOAJ |
| description | Prenatal exposure to elements may be associated with birth weight via shortening of gestation. This study aimed to determine if prenatal exposure is associated with birth weight, and to explore the potential mediating role of gestational age in the association. Within an established Bangladesh prospective birth cohort (2008–2011), we analyzed the concentrations of 15 elements in maternal serum samples collected during the first (n = 780) and second (n = 610) trimesters using inductively coupled plasma mass spectrometry. Mediation analyses explored the relationships between these elements, gestational age, and birth weight. Serum concentrations of cobalt (Co) (first trimester: b = 56.5; 95% confidence interval [CI]: 13.5–99.0; false discovery rate [FDR]-q = 0.035; second trimester: b = 73.3; 95% CI: 20.4–130.2; FDR-q = 0.037) and antimony (Sb) in both trimesters (first trimester: b = 92.1; 95% CI: 66.0–118.9; FDR-q < 0.001; second trimester: b = 93.3; 95% CI: 67.3–118.4; FDR-q < 0.001), and strontium (Sr) in the first trimester (b = 142.4; 95% CI: 41.6–247.9; FDR-q = 0.035) were positively associated with birth weight, while negative associations were observed for barium (Ba) (first trimester: b = −154.8; 95% CI: −217.9 to 91.8; FDR-q <0.001; second trimester: b = −26.7; 95% CI: −44.9 to 10.2; FDR-q < 0.001). These elements act partially by affecting gestation age and appear to have heightened impact among smaller infants. Further research is needed to determine the biological underpinnings of these effects, which may inform strategies to avert low birth weight. |
| first_indexed | 2024-04-11T00:56:28Z |
| format | Article |
| id | doaj.art-56a1efe7b0524a4eb6579d25fe856154 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-04-11T00:56:28Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-56a1efe7b0524a4eb6579d25fe8561542023-01-05T04:30:54ZengElsevierEcotoxicology and Environmental Safety0147-65132023-01-01249114475Novel trace elements detected in multiple stages of pregnancy impact neonatal birth weight by affecting gestational ageLiangmin Wei0Xin Chen1Hui Huang2Ruyang Zhang3Sipeng Shen4Weiwei Duan5Li Su6Hao Yu7David C. Christiani8Yongyue Wei9Feng Chen10Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China; China International Cooperation Center for Environment and Human Health, Center of Global Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USADepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaChina International Cooperation Center for Environment and Human Health, Center of Global Health, Nanjing Medical University, Nanjing 211166, China; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USAPeking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China; China International Cooperation Center for Environment and Human Health, Center of Global Health, Nanjing Medical University, Nanjing 211166, China; Corresponding author at: Science & Technology Building 601, 38 Xueyuan Road, Haidian District, Beijing 100191, China.State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China; Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China; Correspondence to: 101 Longmian Avenue, Nanjing 211166, China.Prenatal exposure to elements may be associated with birth weight via shortening of gestation. This study aimed to determine if prenatal exposure is associated with birth weight, and to explore the potential mediating role of gestational age in the association. Within an established Bangladesh prospective birth cohort (2008–2011), we analyzed the concentrations of 15 elements in maternal serum samples collected during the first (n = 780) and second (n = 610) trimesters using inductively coupled plasma mass spectrometry. Mediation analyses explored the relationships between these elements, gestational age, and birth weight. Serum concentrations of cobalt (Co) (first trimester: b = 56.5; 95% confidence interval [CI]: 13.5–99.0; false discovery rate [FDR]-q = 0.035; second trimester: b = 73.3; 95% CI: 20.4–130.2; FDR-q = 0.037) and antimony (Sb) in both trimesters (first trimester: b = 92.1; 95% CI: 66.0–118.9; FDR-q < 0.001; second trimester: b = 93.3; 95% CI: 67.3–118.4; FDR-q < 0.001), and strontium (Sr) in the first trimester (b = 142.4; 95% CI: 41.6–247.9; FDR-q = 0.035) were positively associated with birth weight, while negative associations were observed for barium (Ba) (first trimester: b = −154.8; 95% CI: −217.9 to 91.8; FDR-q <0.001; second trimester: b = −26.7; 95% CI: −44.9 to 10.2; FDR-q < 0.001). These elements act partially by affecting gestation age and appear to have heightened impact among smaller infants. Further research is needed to determine the biological underpinnings of these effects, which may inform strategies to avert low birth weight.http://www.sciencedirect.com/science/article/pii/S014765132201315XTrace elementsEnvironmental exposureLow birth weightGestational ageBangladeshInductively coupled plasma mass spectrometry |
| spellingShingle | Liangmin Wei Xin Chen Hui Huang Ruyang Zhang Sipeng Shen Weiwei Duan Li Su Hao Yu David C. Christiani Yongyue Wei Feng Chen Novel trace elements detected in multiple stages of pregnancy impact neonatal birth weight by affecting gestational age Ecotoxicology and Environmental Safety Trace elements Environmental exposure Low birth weight Gestational age Bangladesh Inductively coupled plasma mass spectrometry |
| title | Novel trace elements detected in multiple stages of pregnancy impact neonatal birth weight by affecting gestational age |
| title_full | Novel trace elements detected in multiple stages of pregnancy impact neonatal birth weight by affecting gestational age |
| title_fullStr | Novel trace elements detected in multiple stages of pregnancy impact neonatal birth weight by affecting gestational age |
| title_full_unstemmed | Novel trace elements detected in multiple stages of pregnancy impact neonatal birth weight by affecting gestational age |
| title_short | Novel trace elements detected in multiple stages of pregnancy impact neonatal birth weight by affecting gestational age |
| title_sort | novel trace elements detected in multiple stages of pregnancy impact neonatal birth weight by affecting gestational age |
| topic | Trace elements Environmental exposure Low birth weight Gestational age Bangladesh Inductively coupled plasma mass spectrometry |
| url | http://www.sciencedirect.com/science/article/pii/S014765132201315X |
| work_keys_str_mv | AT liangminwei noveltraceelementsdetectedinmultiplestagesofpregnancyimpactneonatalbirthweightbyaffectinggestationalage AT xinchen noveltraceelementsdetectedinmultiplestagesofpregnancyimpactneonatalbirthweightbyaffectinggestationalage AT huihuang noveltraceelementsdetectedinmultiplestagesofpregnancyimpactneonatalbirthweightbyaffectinggestationalage AT ruyangzhang noveltraceelementsdetectedinmultiplestagesofpregnancyimpactneonatalbirthweightbyaffectinggestationalage AT sipengshen noveltraceelementsdetectedinmultiplestagesofpregnancyimpactneonatalbirthweightbyaffectinggestationalage AT weiweiduan noveltraceelementsdetectedinmultiplestagesofpregnancyimpactneonatalbirthweightbyaffectinggestationalage AT lisu noveltraceelementsdetectedinmultiplestagesofpregnancyimpactneonatalbirthweightbyaffectinggestationalage AT haoyu noveltraceelementsdetectedinmultiplestagesofpregnancyimpactneonatalbirthweightbyaffectinggestationalage AT davidcchristiani noveltraceelementsdetectedinmultiplestagesofpregnancyimpactneonatalbirthweightbyaffectinggestationalage AT yongyuewei noveltraceelementsdetectedinmultiplestagesofpregnancyimpactneonatalbirthweightbyaffectinggestationalage AT fengchen noveltraceelementsdetectedinmultiplestagesofpregnancyimpactneonatalbirthweightbyaffectinggestationalage |