Ibrutinib as a bridge to transplant in high-risk chronic lymphocytic leukemia: A case report and review of the literature
The treatment landscape of chronic lymphocytic leukemia (CLL) has been challenged by the advent of novel classes of drugs, such as B-cell receptor (BCR)-inhibitors and BCL-2 antagonists. In selected high-risk patients, the choice to start allogeneic hematopoietic stem cell transplantation (alloHCT)...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-01-01
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| Series: | Leukemia Research Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048917300262 |
| _version_ | 1811194906711949312 |
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| author | Arcari Annalisa Bassi Simona Pochintesta Lara Trabacchi Elena Moroni Carlo Filippo Rossi Angela Zanlari Luca Vallisa Daniele |
| author_facet | Arcari Annalisa Bassi Simona Pochintesta Lara Trabacchi Elena Moroni Carlo Filippo Rossi Angela Zanlari Luca Vallisa Daniele |
| author_sort | Arcari Annalisa |
| collection | DOAJ |
| description | The treatment landscape of chronic lymphocytic leukemia (CLL) has been challenged by the advent of novel classes of drugs, such as B-cell receptor (BCR)-inhibitors and BCL-2 antagonists. In selected high-risk patients, the choice to start allogeneic hematopoietic stem cell transplantation (alloHCT) or continue these agents is a matter of debate. Furthermore, published data about the impact on the feasibility of alloHCT and the optimal timing of administration are limited. Here we present a case of relapsed TP53 mutated CLL treated with ibrutinib as a bridge to alloHCT, discussing risks and benefits of different treatment options in a “real life” situation. |
| first_indexed | 2024-04-12T00:33:59Z |
| format | Article |
| id | doaj.art-56a6c00de4c74ecf9e079bcf41974f8b |
| institution | Directory Open Access Journal |
| issn | 2213-0489 |
| language | English |
| last_indexed | 2024-04-12T00:33:59Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj.art-56a6c00de4c74ecf9e079bcf41974f8b2022-12-22T03:55:12ZengElsevierLeukemia Research Reports2213-04892017-01-018C212310.1016/j.lrr.2017.11.001Ibrutinib as a bridge to transplant in high-risk chronic lymphocytic leukemia: A case report and review of the literatureArcari Annalisa0Bassi Simona1Pochintesta Lara2Trabacchi Elena3Moroni Carlo Filippo4Rossi Angela5Zanlari Luca6Vallisa Daniele7Hematology Unit and Transplantion Center, “Guglielmo da Saliceto” Hospital, via Taverna 49, 29100 Piacenza, ItalyHematology Unit and Transplantion Center, “Guglielmo da Saliceto” Hospital, via Taverna 49, 29100 Piacenza, ItalyHematology Unit and Transplantion Center, “Guglielmo da Saliceto” Hospital, via Taverna 49, 29100 Piacenza, ItalyHematology Unit and Transplantion Center, “Guglielmo da Saliceto” Hospital, via Taverna 49, 29100 Piacenza, ItalyHematology Unit and Transplantion Center, “Guglielmo da Saliceto” Hospital, via Taverna 49, 29100 Piacenza, ItalyTransfusional Centre and Immunohematology, Immunogenetics Laboratory, “Guglielmo da Saliceto” Hospital, via Taverna 49, 29100 Piacenza, ItalyDepartment of Internal Medicine, Valdarda Hospital, via Roma 6, 29017 Fiorenzuola d’Arda, Piacenza, ItalyHematology Unit and Transplantion Center, “Guglielmo da Saliceto” Hospital, via Taverna 49, 29100 Piacenza, ItalyThe treatment landscape of chronic lymphocytic leukemia (CLL) has been challenged by the advent of novel classes of drugs, such as B-cell receptor (BCR)-inhibitors and BCL-2 antagonists. In selected high-risk patients, the choice to start allogeneic hematopoietic stem cell transplantation (alloHCT) or continue these agents is a matter of debate. Furthermore, published data about the impact on the feasibility of alloHCT and the optimal timing of administration are limited. Here we present a case of relapsed TP53 mutated CLL treated with ibrutinib as a bridge to alloHCT, discussing risks and benefits of different treatment options in a “real life” situation.http://www.sciencedirect.com/science/article/pii/S2213048917300262Chronic lymphocytic leukemiaB-cell receptor inhibitorsAllogeneic hematopoietic stem cell transplantationTP53 mutation |
| spellingShingle | Arcari Annalisa Bassi Simona Pochintesta Lara Trabacchi Elena Moroni Carlo Filippo Rossi Angela Zanlari Luca Vallisa Daniele Ibrutinib as a bridge to transplant in high-risk chronic lymphocytic leukemia: A case report and review of the literature Leukemia Research Reports Chronic lymphocytic leukemia B-cell receptor inhibitors Allogeneic hematopoietic stem cell transplantation TP53 mutation |
| title | Ibrutinib as a bridge to transplant in high-risk chronic lymphocytic leukemia: A case report and review of the literature |
| title_full | Ibrutinib as a bridge to transplant in high-risk chronic lymphocytic leukemia: A case report and review of the literature |
| title_fullStr | Ibrutinib as a bridge to transplant in high-risk chronic lymphocytic leukemia: A case report and review of the literature |
| title_full_unstemmed | Ibrutinib as a bridge to transplant in high-risk chronic lymphocytic leukemia: A case report and review of the literature |
| title_short | Ibrutinib as a bridge to transplant in high-risk chronic lymphocytic leukemia: A case report and review of the literature |
| title_sort | ibrutinib as a bridge to transplant in high risk chronic lymphocytic leukemia a case report and review of the literature |
| topic | Chronic lymphocytic leukemia B-cell receptor inhibitors Allogeneic hematopoietic stem cell transplantation TP53 mutation |
| url | http://www.sciencedirect.com/science/article/pii/S2213048917300262 |
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