The Future of Flu: A Review of the Human Challenge Model and Systems Biology for Advancement of Influenza Vaccinology
Objectives: Novel approaches to advance the field of vaccinology must be investigated, and are particularly of importance for influenza in order to produce a more effective vaccine. A systematic review of human challenge studies for influenza was performed, with the goal of assessing safety and ethi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcimb.2019.00107/full |
| _version_ | 1818927327492440064 |
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| author | Amy Caryn Sherman Aneesh Mehta Neal W. Dickert Evan J. Anderson Nadine Rouphael |
| author_facet | Amy Caryn Sherman Aneesh Mehta Neal W. Dickert Evan J. Anderson Nadine Rouphael |
| author_sort | Amy Caryn Sherman |
| collection | DOAJ |
| description | Objectives: Novel approaches to advance the field of vaccinology must be investigated, and are particularly of importance for influenza in order to produce a more effective vaccine. A systematic review of human challenge studies for influenza was performed, with the goal of assessing safety and ethics and determining how these studies have led to therapeutic and vaccine development. A systematic review of systems biology approaches for the study of influenza was also performed, with a focus on how this technology has been utilized for influenza vaccine development.Methods: The PubMed database was searched for influenza human challenge studies, and for systems biology studies that have addressed both influenza infection and immunological effects of vaccination.Results: Influenza human challenge studies have led to important advancements in therapeutics and influenza immunization, and can be performed safely and ethically if certain criteria are met. Many studies have investigated the use of systems biology for evaluating immune response to influenza vaccine, and several promising molecular signatures may help advance our understanding of pathogenesis and be used as targets for influenza interventions. Combining these methodologies has the potential to lead to significant advances in the field of influenza vaccinology and therapeutics.Conclusions: Human challenge studies and systems biology approaches are important tools that should be used in concert to advance our understanding of influenza infection and provide targets for novel therapeutics and immunizations. |
| first_indexed | 2024-12-20T03:11:15Z |
| format | Article |
| id | doaj.art-56aa18b1332c4ea08ebf427c09485cfc |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-20T03:11:15Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-56aa18b1332c4ea08ebf427c09485cfc2022-12-21T19:55:28ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882019-04-01910.3389/fcimb.2019.00107451881The Future of Flu: A Review of the Human Challenge Model and Systems Biology for Advancement of Influenza VaccinologyAmy Caryn ShermanAneesh MehtaNeal W. DickertEvan J. AndersonNadine RouphaelObjectives: Novel approaches to advance the field of vaccinology must be investigated, and are particularly of importance for influenza in order to produce a more effective vaccine. A systematic review of human challenge studies for influenza was performed, with the goal of assessing safety and ethics and determining how these studies have led to therapeutic and vaccine development. A systematic review of systems biology approaches for the study of influenza was also performed, with a focus on how this technology has been utilized for influenza vaccine development.Methods: The PubMed database was searched for influenza human challenge studies, and for systems biology studies that have addressed both influenza infection and immunological effects of vaccination.Results: Influenza human challenge studies have led to important advancements in therapeutics and influenza immunization, and can be performed safely and ethically if certain criteria are met. Many studies have investigated the use of systems biology for evaluating immune response to influenza vaccine, and several promising molecular signatures may help advance our understanding of pathogenesis and be used as targets for influenza interventions. Combining these methodologies has the potential to lead to significant advances in the field of influenza vaccinology and therapeutics.Conclusions: Human challenge studies and systems biology approaches are important tools that should be used in concert to advance our understanding of influenza infection and provide targets for novel therapeutics and immunizations.https://www.frontiersin.org/article/10.3389/fcimb.2019.00107/fullhuman challenge modelinfluenza vaccinationsystems biologyuniversal influenza vaccinationbioethicstranscriptomics |
| spellingShingle | Amy Caryn Sherman Aneesh Mehta Neal W. Dickert Evan J. Anderson Nadine Rouphael The Future of Flu: A Review of the Human Challenge Model and Systems Biology for Advancement of Influenza Vaccinology Frontiers in Cellular and Infection Microbiology human challenge model influenza vaccination systems biology universal influenza vaccination bioethics transcriptomics |
| title | The Future of Flu: A Review of the Human Challenge Model and Systems Biology for Advancement of Influenza Vaccinology |
| title_full | The Future of Flu: A Review of the Human Challenge Model and Systems Biology for Advancement of Influenza Vaccinology |
| title_fullStr | The Future of Flu: A Review of the Human Challenge Model and Systems Biology for Advancement of Influenza Vaccinology |
| title_full_unstemmed | The Future of Flu: A Review of the Human Challenge Model and Systems Biology for Advancement of Influenza Vaccinology |
| title_short | The Future of Flu: A Review of the Human Challenge Model and Systems Biology for Advancement of Influenza Vaccinology |
| title_sort | future of flu a review of the human challenge model and systems biology for advancement of influenza vaccinology |
| topic | human challenge model influenza vaccination systems biology universal influenza vaccination bioethics transcriptomics |
| url | https://www.frontiersin.org/article/10.3389/fcimb.2019.00107/full |
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