Association of Chlamydophila pneumoniae infection and hypertension during pregnancy – A case control study
BACKGROUND: The association of Chlamydophila pneumoniae infection with essential hypertension is known but its association with hypertension during pregnancy is controversial. Hence, this study aimed to explore the association of C. pneumoniae infection with hypertension during pregnancy. The object...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-11-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2021.1969661 |
| _version_ | 1797681095144112128 |
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| author | Bhagyashree Gundagurti Papa Dasari Rakesh Singh |
| author_facet | Bhagyashree Gundagurti Papa Dasari Rakesh Singh |
| author_sort | Bhagyashree Gundagurti |
| collection | DOAJ |
| description | BACKGROUND: The association of Chlamydophila pneumoniae infection with essential hypertension is known but its association with hypertension during pregnancy is controversial. Hence, this study aimed to explore the association of C. pneumoniae infection with hypertension during pregnancy. The objectives were to compare the presence of C. pneumoniae DNA in trophoblastic cells of placenta between hypertensive and normotensive pregnant women and to find out the presence of inflammatory marker (HSP-60) and the seropositivity (IgG and IgA) of C. pneumoniae in them. MATERIALS AND METHODS: The study was conducted at a tertiary-care institute, in South-India between 2018 and 2020. Women with hypertension during pregnancy were study group (75) and normotensive pregnant women were control group (75). IgG and IgA antibodies, HSP-60 against C. pneumoniae were estimated by ELISA from 5 ml of venous blood. C. pneumoniae DNA was extracted from placental tissue after delivery and tested by RT-PCR. STATISTICAL ANALYSIS: The association between C. pneumoniae DNA, seropositivity and hypertension was determined by student test and univariate regression analysis. RESULTS: C. pneumoniae DNA was detected in the placenta of 29.3% with hypertension and none in controls and the odds was 6.5 (OR-6.5, CI 95%). HSP-60 was elevated in women with preeclampsia and not in gestational hypertension and controls. IgA was not detected and IgG was positive in 15.2% of women with preeclampsia. CONCLUSION: There is a significant association between C. pneumoniae infection and hypertension during pregnancy and further studies are required to fulfil the Koch’s postulates to prove or disprove it as a causative agent. |
| first_indexed | 2024-03-11T23:39:53Z |
| format | Article |
| id | doaj.art-56ab35028627429e8b7320ea2caf7928 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:39:53Z |
| publishDate | 2021-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-56ab35028627429e8b7320ea2caf79282023-09-19T16:04:07ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062021-11-0143879379910.1080/10641963.2021.19696611969661Association of Chlamydophila pneumoniae infection and hypertension during pregnancy – A case control studyBhagyashree Gundagurti0Papa Dasari1Rakesh Singh2JIPMERJIPMERJIPMERBACKGROUND: The association of Chlamydophila pneumoniae infection with essential hypertension is known but its association with hypertension during pregnancy is controversial. Hence, this study aimed to explore the association of C. pneumoniae infection with hypertension during pregnancy. The objectives were to compare the presence of C. pneumoniae DNA in trophoblastic cells of placenta between hypertensive and normotensive pregnant women and to find out the presence of inflammatory marker (HSP-60) and the seropositivity (IgG and IgA) of C. pneumoniae in them. MATERIALS AND METHODS: The study was conducted at a tertiary-care institute, in South-India between 2018 and 2020. Women with hypertension during pregnancy were study group (75) and normotensive pregnant women were control group (75). IgG and IgA antibodies, HSP-60 against C. pneumoniae were estimated by ELISA from 5 ml of venous blood. C. pneumoniae DNA was extracted from placental tissue after delivery and tested by RT-PCR. STATISTICAL ANALYSIS: The association between C. pneumoniae DNA, seropositivity and hypertension was determined by student test and univariate regression analysis. RESULTS: C. pneumoniae DNA was detected in the placenta of 29.3% with hypertension and none in controls and the odds was 6.5 (OR-6.5, CI 95%). HSP-60 was elevated in women with preeclampsia and not in gestational hypertension and controls. IgA was not detected and IgG was positive in 15.2% of women with preeclampsia. CONCLUSION: There is a significant association between C. pneumoniae infection and hypertension during pregnancy and further studies are required to fulfil the Koch’s postulates to prove or disprove it as a causative agent.http://dx.doi.org/10.1080/10641963.2021.1969661chlamydophila pneumoniae- dnac.hsp-60igg and iga antibodieshypertensive disorder during pregnancy |
| spellingShingle | Bhagyashree Gundagurti Papa Dasari Rakesh Singh Association of Chlamydophila pneumoniae infection and hypertension during pregnancy – A case control study Clinical and Experimental Hypertension chlamydophila pneumoniae- dna c.hsp-60 igg and iga antibodies hypertensive disorder during pregnancy |
| title | Association of Chlamydophila pneumoniae infection and hypertension during pregnancy – A case control study |
| title_full | Association of Chlamydophila pneumoniae infection and hypertension during pregnancy – A case control study |
| title_fullStr | Association of Chlamydophila pneumoniae infection and hypertension during pregnancy – A case control study |
| title_full_unstemmed | Association of Chlamydophila pneumoniae infection and hypertension during pregnancy – A case control study |
| title_short | Association of Chlamydophila pneumoniae infection and hypertension during pregnancy – A case control study |
| title_sort | association of chlamydophila pneumoniae infection and hypertension during pregnancy a case control study |
| topic | chlamydophila pneumoniae- dna c.hsp-60 igg and iga antibodies hypertensive disorder during pregnancy |
| url | http://dx.doi.org/10.1080/10641963.2021.1969661 |
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