Development and evaluation of lafutidine solid dispersion via hot melt extrusion: Investigating drug-polymer miscibility with advanced characterisation

Development and evaluation of lafutidine solid dispersion via hot melt extrusion: Investigating drug-polymer miscibility with advanced characterisation

In current study, immediate release solid dispersion (SD) formulation of antiulcer drug lafutidine (LAFT) was developed using hot melt extrusion (HME) technique. Amphiphilic Soluplus® used as a primary solubilizing agent, with different concentrations of selected surfactants like PEG 400, Lutrol F12...

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Bibliographic Details
Main Authors:	Ritesh Fule, Purnima Amin
Format:	Article
Language:	English
Published:	Elsevier 2014-04-01
Series:	Asian Journal of Pharmaceutical Sciences
Subjects:	Lafutidine Solid dispersion Hot melt extrusion Dissolution rate Raman spectroscopy Atomic force microscopy
Online Access:	http://www.sciencedirect.com/science/article/pii/S1818087613000809

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