Gene–gene and gene-environment interactions on cord blood total IgE in Chinese Han children
Abstract Background IL13, IL4, IL4RA, FCER1B and ADRB2 are susceptible genes of asthma and atopy. Our previous study has found gene–gene interactions on asthma between these genes in Chinese Han children. Whether the interactions begin in fetal stage, and whether these genes interact with prenatal e...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | Allergy, Asthma & Clinical Immunology |
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| Online Access: | https://doi.org/10.1186/s13223-021-00571-0 |
| _version_ | 1818678384398434304 |
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| author | Li Hua Quanhua Liu Jing Li Xianbo Zuo Qian Chen Jingyang Li Yuwei Wang Haipei Liu Zhaobo Shen Yi Li Zenan Ma Shengdong Dong Ruoxu Ji Dingzhu Fang Yi Chen Wenwei Zhong Jun Zhang Jianhua Zhang Yixiao Bao |
| author_facet | Li Hua Quanhua Liu Jing Li Xianbo Zuo Qian Chen Jingyang Li Yuwei Wang Haipei Liu Zhaobo Shen Yi Li Zenan Ma Shengdong Dong Ruoxu Ji Dingzhu Fang Yi Chen Wenwei Zhong Jun Zhang Jianhua Zhang Yixiao Bao |
| author_sort | Li Hua |
| collection | DOAJ |
| description | Abstract Background IL13, IL4, IL4RA, FCER1B and ADRB2 are susceptible genes of asthma and atopy. Our previous study has found gene–gene interactions on asthma between these genes in Chinese Han children. Whether the interactions begin in fetal stage, and whether these genes interact with prenatal environment to enhance cord blood IgE (CBIgE) levels and then cause subsequent allergic diseases have yet to be determined. This study aimed to determine whether there are gene–gene and gene-environment interactions on CBIgE elevation among the aforementioned five genes and prenatal environmental factors in Chinese Han population. Methods 989 cord blood samples from a Chinese birth cohort were genotyped for nine single-nucleotide polymorphisms (SNPs) in the five genes, and measured for CBIgE levels. Prenatal environmental factors were collected using a questionnaire. Gene–gene and gene-environment interactions were analyzed with generalized multifactor dimensionality methods. Results A four-way gene–gene interaction model (IL13 rs20541, IL13 rs1800925, IL4 rs2243250 and ADRB2 rs1042713) was regarded as the optimal one for CBIgE elevation (testing balanced accuracy = 0.5805, P = 9.03 × 10–4). Among the four SNPs, only IL13 rs20541 was identified to have an independent effect on elevated CBIgE (odds ratio (OR) = 1.36, P = 3.57 × 10–3), while the other three had small but synergistic effects. Carriers of IL13 rs20541 TT, IL13 rs1800925 CT/TT, IL4 rs2243250 TT and ADRB2 rs1042713 AA were estimated to be at more than fourfold higher risk for CBIgE elevation (OR = 4.14, P = 2.69 × 10–2). Gene-environment interaction on elevated CBIgE was found between IL4 rs2243250 and maternal atopy (OR = 1.41, P = 2.65 × 10–2). Conclusions Gene–gene interaction between IL13 rs20541, IL13 rs1800925, IL4 rs2243250 and ADRB2 rs1042713, and gene-environment interaction between IL4 rs2243250 and maternal atopy begin in prenatal stage to augment IgE production in Chinese Han children. |
| first_indexed | 2024-12-17T09:14:24Z |
| format | Article |
| id | doaj.art-56ae0f4c3c504b25905f1aea8fd5a673 |
| institution | Directory Open Access Journal |
| issn | 1710-1492 |
| language | English |
| last_indexed | 2024-12-17T09:14:24Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
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| series | Allergy, Asthma & Clinical Immunology |
| spelling | doaj.art-56ae0f4c3c504b25905f1aea8fd5a6732022-12-21T21:55:03ZengBMCAllergy, Asthma & Clinical Immunology1710-14922021-07-011711810.1186/s13223-021-00571-0Gene–gene and gene-environment interactions on cord blood total IgE in Chinese Han childrenLi Hua0Quanhua Liu1Jing Li2Xianbo Zuo3Qian Chen4Jingyang Li5Yuwei Wang6Haipei Liu7Zhaobo Shen8Yi Li9Zenan Ma10Shengdong Dong11Ruoxu Ji12Dingzhu Fang13Yi Chen14Wenwei Zhong15Jun Zhang16Jianhua Zhang17Yixiao Bao18Department of Pediatric Pulmonology, Xin Hua Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Pediatric Pulmonology, Xin Hua Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Pediatric Pulmonology, Xin Hua Hospital, Shanghai Jiao Tong University School of MedicineKey Laboratory of Dermatology, Ministry of Education, Anhui Medical UniversityMinistry of Education-Shanghai Key Laboratory of Children’s Environmental Health, Xin Hua Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Pediatric Pulmonology, Xin Hua Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Pediatric Pulmonology, Xin Hua Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Pulmonology, Children’s Hospital, Zhengzhou UniversityDepartment of Pulmonology, Children’s Hospital, Zhengzhou UniversityDepartment of Pediatrics, Suzhou Wuzhong People’s HospitalMedical Department, Shanghai Seventh People’s Hospital, Shanghai University of Traditional Chinese MedicineDepartment of Pediatric Pulmonology, Xin Hua Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Pediatric Pulmonology, Xin Hua Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Pediatric Pulmonology, Xin Hua Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Pediatric Pulmonology, Xin Hua Hospital, Shanghai Jiao Tong University School of MedicineMinistry of Education-Shanghai Key Laboratory of Children’s Environmental Health, Xin Hua Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Pediatric Pulmonology, Xin Hua Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Pediatric Pulmonology, Xin Hua Hospital, Shanghai Jiao Tong University School of MedicineAbstract Background IL13, IL4, IL4RA, FCER1B and ADRB2 are susceptible genes of asthma and atopy. Our previous study has found gene–gene interactions on asthma between these genes in Chinese Han children. Whether the interactions begin in fetal stage, and whether these genes interact with prenatal environment to enhance cord blood IgE (CBIgE) levels and then cause subsequent allergic diseases have yet to be determined. This study aimed to determine whether there are gene–gene and gene-environment interactions on CBIgE elevation among the aforementioned five genes and prenatal environmental factors in Chinese Han population. Methods 989 cord blood samples from a Chinese birth cohort were genotyped for nine single-nucleotide polymorphisms (SNPs) in the five genes, and measured for CBIgE levels. Prenatal environmental factors were collected using a questionnaire. Gene–gene and gene-environment interactions were analyzed with generalized multifactor dimensionality methods. Results A four-way gene–gene interaction model (IL13 rs20541, IL13 rs1800925, IL4 rs2243250 and ADRB2 rs1042713) was regarded as the optimal one for CBIgE elevation (testing balanced accuracy = 0.5805, P = 9.03 × 10–4). Among the four SNPs, only IL13 rs20541 was identified to have an independent effect on elevated CBIgE (odds ratio (OR) = 1.36, P = 3.57 × 10–3), while the other three had small but synergistic effects. Carriers of IL13 rs20541 TT, IL13 rs1800925 CT/TT, IL4 rs2243250 TT and ADRB2 rs1042713 AA were estimated to be at more than fourfold higher risk for CBIgE elevation (OR = 4.14, P = 2.69 × 10–2). Gene-environment interaction on elevated CBIgE was found between IL4 rs2243250 and maternal atopy (OR = 1.41, P = 2.65 × 10–2). Conclusions Gene–gene interaction between IL13 rs20541, IL13 rs1800925, IL4 rs2243250 and ADRB2 rs1042713, and gene-environment interaction between IL4 rs2243250 and maternal atopy begin in prenatal stage to augment IgE production in Chinese Han children.https://doi.org/10.1186/s13223-021-00571-0Cord bloodIgEGene—gene interactionGene—environment interaction |
| spellingShingle | Li Hua Quanhua Liu Jing Li Xianbo Zuo Qian Chen Jingyang Li Yuwei Wang Haipei Liu Zhaobo Shen Yi Li Zenan Ma Shengdong Dong Ruoxu Ji Dingzhu Fang Yi Chen Wenwei Zhong Jun Zhang Jianhua Zhang Yixiao Bao Gene–gene and gene-environment interactions on cord blood total IgE in Chinese Han children Allergy, Asthma & Clinical Immunology Cord blood IgE Gene—gene interaction Gene—environment interaction |
| title | Gene–gene and gene-environment interactions on cord blood total IgE in Chinese Han children |
| title_full | Gene–gene and gene-environment interactions on cord blood total IgE in Chinese Han children |
| title_fullStr | Gene–gene and gene-environment interactions on cord blood total IgE in Chinese Han children |
| title_full_unstemmed | Gene–gene and gene-environment interactions on cord blood total IgE in Chinese Han children |
| title_short | Gene–gene and gene-environment interactions on cord blood total IgE in Chinese Han children |
| title_sort | gene gene and gene environment interactions on cord blood total ige in chinese han children |
| topic | Cord blood IgE Gene—gene interaction Gene—environment interaction |
| url | https://doi.org/10.1186/s13223-021-00571-0 |
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