Twenty-Year Public Health Impact of 7- and 13-Valent Pneumococcal Conjugate Vaccines in US Children
Pneumococcal conjugate vaccines (PCVs) have been used in the United States since 2000. To assess the cumulative 20-year effect of PCVs on invasive pneumococcal disease (IPD) incidence among children <5 years of age, we analyzed Active Bacterial Core Surveillance data, conducted a literature revie...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2021-06-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/27/6/20-4238_article |
| _version_ | 1818902191028568064 |
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| author | Matt Wasserman Ruth Chapman Rotem Lapidot Kelly Sutton Desmond Dillon-Murphy Shreeya Patel Erica Chilson Vincenza Snow Raymond Farkouh Stephen Pelton |
| author_facet | Matt Wasserman Ruth Chapman Rotem Lapidot Kelly Sutton Desmond Dillon-Murphy Shreeya Patel Erica Chilson Vincenza Snow Raymond Farkouh Stephen Pelton |
| author_sort | Matt Wasserman |
| collection | DOAJ |
| description | Pneumococcal conjugate vaccines (PCVs) have been used in the United States since 2000. To assess the cumulative 20-year effect of PCVs on invasive pneumococcal disease (IPD) incidence among children <5 years of age, we analyzed Active Bacterial Core Surveillance data, conducted a literature review, and modeled expected and observed disease. We found that PCVs have averted >282,000 cases of IPD, including ≈16,000 meningitis, ≈172,000 bacteremia, and ≈55,000 bacteremic pneumonia cases. In addition, vaccination has prevented 97 million healthcare visits for otitis media, 438,914–706,345 hospitalizations for pneumonia, and 2,780 total deaths. IPD cases declined 91%, from 15,707 in 1997 to 1,382 in 2019. Average annual visits for otitis media declined 41%, from 78 visits/100 children before PCV introduction to 46 visits/100 children after PCV13 introduction. Annual pneumonia hospitalizations declined 66%–79%, from 110,000–175,000 in 1997 to 37,000 in 2019. These findings confirm the substantial benefits of PCVs for preventing IPD in children. |
| first_indexed | 2024-12-19T20:31:43Z |
| format | Article |
| id | doaj.art-56b656ace98144438f269a98cf699d40 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-19T20:31:43Z |
| publishDate | 2021-06-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-56b656ace98144438f269a98cf699d402022-12-21T20:06:40ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592021-06-012761627163610.3201/eid2706.204238Twenty-Year Public Health Impact of 7- and 13-Valent Pneumococcal Conjugate Vaccines in US ChildrenMatt WassermanRuth ChapmanRotem LapidotKelly SuttonDesmond Dillon-MurphyShreeya PatelErica ChilsonVincenza SnowRaymond FarkouhStephen PeltonPneumococcal conjugate vaccines (PCVs) have been used in the United States since 2000. To assess the cumulative 20-year effect of PCVs on invasive pneumococcal disease (IPD) incidence among children <5 years of age, we analyzed Active Bacterial Core Surveillance data, conducted a literature review, and modeled expected and observed disease. We found that PCVs have averted >282,000 cases of IPD, including ≈16,000 meningitis, ≈172,000 bacteremia, and ≈55,000 bacteremic pneumonia cases. In addition, vaccination has prevented 97 million healthcare visits for otitis media, 438,914–706,345 hospitalizations for pneumonia, and 2,780 total deaths. IPD cases declined 91%, from 15,707 in 1997 to 1,382 in 2019. Average annual visits for otitis media declined 41%, from 78 visits/100 children before PCV introduction to 46 visits/100 children after PCV13 introduction. Annual pneumonia hospitalizations declined 66%–79%, from 110,000–175,000 in 1997 to 37,000 in 2019. These findings confirm the substantial benefits of PCVs for preventing IPD in children.https://wwwnc.cdc.gov/eid/article/27/6/20-4238_articlechildrenincidenceinvasive pneumococcal diseaseIPDotitis mediapneumococcal disease |
| spellingShingle | Matt Wasserman Ruth Chapman Rotem Lapidot Kelly Sutton Desmond Dillon-Murphy Shreeya Patel Erica Chilson Vincenza Snow Raymond Farkouh Stephen Pelton Twenty-Year Public Health Impact of 7- and 13-Valent Pneumococcal Conjugate Vaccines in US Children Emerging Infectious Diseases children incidence invasive pneumococcal disease IPD otitis media pneumococcal disease |
| title | Twenty-Year Public Health Impact of 7- and 13-Valent Pneumococcal Conjugate Vaccines in US Children |
| title_full | Twenty-Year Public Health Impact of 7- and 13-Valent Pneumococcal Conjugate Vaccines in US Children |
| title_fullStr | Twenty-Year Public Health Impact of 7- and 13-Valent Pneumococcal Conjugate Vaccines in US Children |
| title_full_unstemmed | Twenty-Year Public Health Impact of 7- and 13-Valent Pneumococcal Conjugate Vaccines in US Children |
| title_short | Twenty-Year Public Health Impact of 7- and 13-Valent Pneumococcal Conjugate Vaccines in US Children |
| title_sort | twenty year public health impact of 7 and 13 valent pneumococcal conjugate vaccines in us children |
| topic | children incidence invasive pneumococcal disease IPD otitis media pneumococcal disease |
| url | https://wwwnc.cdc.gov/eid/article/27/6/20-4238_article |
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