Association of genetic polymorphism of a gene TNF-α (G-308A) with formation of the serious and complicated forms of a influenza at children
Research of prevalence of a polymorphic marker of a gene of the factor of a necrosis of tumors-α G-308A at 201 children is carried out at the uncomplicated and complicated current of influenza A H1N1pdm09. It is established, that frequency of prevalence of genotypes G/G and G/A at children with not...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2014-09-01
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| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/198 |
| _version_ | 1797702627217113088 |
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| author | N. A. Miromanova |
| author_facet | N. A. Miromanova |
| author_sort | N. A. Miromanova |
| collection | DOAJ |
| description | Research of prevalence of a polymorphic marker of a gene of the factor of a necrosis of tumors-α G-308A at 201 children is carried out at the uncomplicated and complicated current of influenza A H1N1pdm09. It is established, that frequency of prevalence of genotypes G/G and G/A at children with not serious forms of influenza A H1N1pdm09 and at a seasonal influenza corresponds population. In case of development of a pneumonia in children at influenza A H1N1pdm09, irrespective of gravity of its current, and also at a serious current of a bacterial pneumonia, distribution of genotypes G/G and G/A differed from healthy population of children. It is revealed, that an allele A polymorphism G-308A of a gene of the factor of a necrosis of tumors-α associations with development of the serious and complicated current of influenza A H1N1pdm09. |
| first_indexed | 2024-03-12T04:52:50Z |
| format | Article |
| id | doaj.art-56b8aee3f795444595baede473ae8827 |
| institution | Directory Open Access Journal |
| issn | 2072-6732 |
| language | Russian |
| last_indexed | 2024-03-12T04:52:50Z |
| publishDate | 2014-09-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj.art-56b8aee3f795444595baede473ae88272023-09-03T09:18:12ZrusJournal InfectologyЖурнал инфектологии2072-67322014-09-0154303510.22625/2072-6732-2013-5-4-30-35212Association of genetic polymorphism of a gene TNF-α (G-308A) with formation of the serious and complicated forms of a influenza at childrenN. A. Miromanova0Читинская государственная медицинская академия, ЧитаResearch of prevalence of a polymorphic marker of a gene of the factor of a necrosis of tumors-α G-308A at 201 children is carried out at the uncomplicated and complicated current of influenza A H1N1pdm09. It is established, that frequency of prevalence of genotypes G/G and G/A at children with not serious forms of influenza A H1N1pdm09 and at a seasonal influenza corresponds population. In case of development of a pneumonia in children at influenza A H1N1pdm09, irrespective of gravity of its current, and also at a serious current of a bacterial pneumonia, distribution of genotypes G/G and G/A differed from healthy population of children. It is revealed, that an allele A polymorphism G-308A of a gene of the factor of a necrosis of tumors-α associations with development of the serious and complicated current of influenza A H1N1pdm09.https://journal.niidi.ru/jofin/article/view/198грипппневмониядетиполиморфизмцитокины |
| spellingShingle | N. A. Miromanova Association of genetic polymorphism of a gene TNF-α (G-308A) with formation of the serious and complicated forms of a influenza at children Журнал инфектологии грипп пневмония дети полиморфизм цитокины |
| title | Association of genetic polymorphism of a gene TNF-α (G-308A) with formation of the serious and complicated forms of a influenza at children |
| title_full | Association of genetic polymorphism of a gene TNF-α (G-308A) with formation of the serious and complicated forms of a influenza at children |
| title_fullStr | Association of genetic polymorphism of a gene TNF-α (G-308A) with formation of the serious and complicated forms of a influenza at children |
| title_full_unstemmed | Association of genetic polymorphism of a gene TNF-α (G-308A) with formation of the serious and complicated forms of a influenza at children |
| title_short | Association of genetic polymorphism of a gene TNF-α (G-308A) with formation of the serious and complicated forms of a influenza at children |
| title_sort | association of genetic polymorphism of a gene tnf α g 308a with formation of the serious and complicated forms of a influenza at children |
| topic | грипп пневмония дети полиморфизм цитокины |
| url | https://journal.niidi.ru/jofin/article/view/198 |
| work_keys_str_mv | AT namiromanova associationofgeneticpolymorphismofagenetnfag308awithformationoftheseriousandcomplicatedformsofainfluenzaatchildren |