Differential regulation of diacylglycerol kinase isoform in human failing hearts
<p>Abstract</p> <p>Evidence from several studies indicates the importance of Gαq protein-coupled receptor (GPCR) signaling pathway, which includes diacylglycerol (DAG), and protein kinase C, in the development of heart failure. DAG kinase (DGK) acts as an endogenous regulator of GP...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-05-01
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| Series: | Journal of Cardiothoracic Surgery |
| Online Access: | http://www.cardiothoracicsurgery.org/content/6/1/65 |
| _version_ | 1828214220406128640 |
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| author | Sadahiro Mitsuaki Kitahara Tatsuro Sasaki Toshiki Suzuki Satoshi Toyama Shuji Shishido Tetsuro Bilim Olga Takeishi Yasuchika Kubota Isao |
| author_facet | Sadahiro Mitsuaki Kitahara Tatsuro Sasaki Toshiki Suzuki Satoshi Toyama Shuji Shishido Tetsuro Bilim Olga Takeishi Yasuchika Kubota Isao |
| author_sort | Sadahiro Mitsuaki |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Evidence from several studies indicates the importance of Gαq protein-coupled receptor (GPCR) signaling pathway, which includes diacylglycerol (DAG), and protein kinase C, in the development of heart failure. DAG kinase (DGK) acts as an endogenous regulator of GPCR signaling pathway by catalyzing and regulating DAG. Expressions of DGK isoforms α, ε, and ζ in rodent hearts have been detected; however, the expression and alteration of DGK isoforms in a failing human heart has not yet been examined. In this study, we detected mRNA expressions of DGK isoforms γ, η, ε, and ζ in failing human heart samples obtained from patients undergoing cardiovascular surgery with cardiopulmonary bypass. Furthermore, we investigated modulation of DGK isoform expression in these hearts. We found that expressions of DGKη and DGKζ were increased and decreased, respectively, whereas those of DGKγ and DGKε remained unchanged. This is the first report that describes the differential regulation of DGK isoforms in normal and failing human hearts.</p> |
| first_indexed | 2024-04-12T15:00:53Z |
| format | Article |
| id | doaj.art-56b9a45052894340ba6cb165f3854833 |
| institution | Directory Open Access Journal |
| issn | 1749-8090 |
| language | English |
| last_indexed | 2024-04-12T15:00:53Z |
| publishDate | 2011-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj.art-56b9a45052894340ba6cb165f38548332022-12-22T03:28:05ZengBMCJournal of Cardiothoracic Surgery1749-80902011-05-01616510.1186/1749-8090-6-65Differential regulation of diacylglycerol kinase isoform in human failing heartsSadahiro MitsuakiKitahara TatsuroSasaki ToshikiSuzuki SatoshiToyama ShujiShishido TetsuroBilim OlgaTakeishi YasuchikaKubota Isao<p>Abstract</p> <p>Evidence from several studies indicates the importance of Gαq protein-coupled receptor (GPCR) signaling pathway, which includes diacylglycerol (DAG), and protein kinase C, in the development of heart failure. DAG kinase (DGK) acts as an endogenous regulator of GPCR signaling pathway by catalyzing and regulating DAG. Expressions of DGK isoforms α, ε, and ζ in rodent hearts have been detected; however, the expression and alteration of DGK isoforms in a failing human heart has not yet been examined. In this study, we detected mRNA expressions of DGK isoforms γ, η, ε, and ζ in failing human heart samples obtained from patients undergoing cardiovascular surgery with cardiopulmonary bypass. Furthermore, we investigated modulation of DGK isoform expression in these hearts. We found that expressions of DGKη and DGKζ were increased and decreased, respectively, whereas those of DGKγ and DGKε remained unchanged. This is the first report that describes the differential regulation of DGK isoforms in normal and failing human hearts.</p>http://www.cardiothoracicsurgery.org/content/6/1/65 |
| spellingShingle | Sadahiro Mitsuaki Kitahara Tatsuro Sasaki Toshiki Suzuki Satoshi Toyama Shuji Shishido Tetsuro Bilim Olga Takeishi Yasuchika Kubota Isao Differential regulation of diacylglycerol kinase isoform in human failing hearts Journal of Cardiothoracic Surgery |
| title | Differential regulation of diacylglycerol kinase isoform in human failing hearts |
| title_full | Differential regulation of diacylglycerol kinase isoform in human failing hearts |
| title_fullStr | Differential regulation of diacylglycerol kinase isoform in human failing hearts |
| title_full_unstemmed | Differential regulation of diacylglycerol kinase isoform in human failing hearts |
| title_short | Differential regulation of diacylglycerol kinase isoform in human failing hearts |
| title_sort | differential regulation of diacylglycerol kinase isoform in human failing hearts |
| url | http://www.cardiothoracicsurgery.org/content/6/1/65 |
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