Amphiregulin induces CCN2 and fibronectin expression by TGF-β through EGFR-dependent pathway in lung epithelial cells

Amphiregulin induces CCN2 and fibronectin expression by TGF-β through EGFR-dependent pathway in lung epithelial cells

Abstract Background Airway fibrosis is one of the pathological characteristics of severe asthma. Transforming growth factor (TGF)-β has been known to promote epithelial-mesenchymal transition formation and to play a role in the progression of tissue fibrosis. Cellular communication network factor 2...

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Bibliographic Details
Main Authors: Wun-Hao Cheng, Shih-Ya Kao, Chia-Ling Chen, Fara Silvia Yuliani, Lee-Yuan Lin, Chien-Huang Lin, Bing-Chang Chen
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Respiratory Research
Subjects:
Severe asthma
Amphiregulin
TGF-β
CCN2
EMT
Airway fibrosis
Online Access:https://doi.org/10.1186/s12931-022-02285-2

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