Asthmatic Eosinophils Alter the Gene Expression of Extracellular Matrix Proteins in Airway Smooth Muscle Cells and Pulmonary Fibroblasts

Asthmatic Eosinophils Alter the Gene Expression of Extracellular Matrix Proteins in Airway Smooth Muscle Cells and Pulmonary Fibroblasts

The impaired production of extracellular matrix (ECM) proteins by airway smooth muscle cells (ASMC) and pulmonary fibroblasts (PF) is a part of airway remodeling in asthma. This process might be influenced by eosinophils that migrate to the airway and abundantly secrete various cytokines, including...

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Bibliographic Details
Main Authors: Ieva Janulaityte, Andrius Januskevicius, Airidas Rimkunas, Jolita Palacionyte, Astra Vitkauskiene, Kestutis Malakauskas
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
asthma
allergy
eosinophil
extracellular matrix proteins
TGF-β signaling pathway
airway smooth muscle cells
Online Access:https://www.mdpi.com/1422-0067/23/8/4086

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