Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (<it>p</it>-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations
<p>Abstract</p> <p>Background</p> <p>The study is part of a collaborative project (Inuendo), aiming to assess the impact of dietary persistent organochlorine pollutants (POPs) on human fertility. The aims with the present study are to analyze inter-population variations...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2005-11-01
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| Series: | Environmental Health |
| Online Access: | http://www.ehjournal.net/content/4/1/27 |
| _version_ | 1818136032171786240 |
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| author | Bonefeld-Jörgensen Eva C Bizzaro Davide Spanò Marcello Zvyezday Valentyna Góralczyk Katarzyna Ludwicki Jan K Pedersen Henning S Toft Gunnar Giwercman Aleksander Rignell-Hydbom Anna Lindh Christian Rylander Lars Jönsson Bo AG Manicardi Gian Bonde Jens Hagmar Lars |
| author_facet | Bonefeld-Jörgensen Eva C Bizzaro Davide Spanò Marcello Zvyezday Valentyna Góralczyk Katarzyna Ludwicki Jan K Pedersen Henning S Toft Gunnar Giwercman Aleksander Rignell-Hydbom Anna Lindh Christian Rylander Lars Jönsson Bo AG Manicardi Gian Bonde Jens Hagmar Lars |
| author_sort | Bonefeld-Jörgensen Eva C |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The study is part of a collaborative project (Inuendo), aiming to assess the impact of dietary persistent organochlorine pollutants (POPs) on human fertility. The aims with the present study are to analyze inter-population variations in serum concentrations of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (<it>p</it>-chlorophenyl)-ethylene (p,p'-DDE), to assess inter-population variations in biomarker correlations, and to evaluate the relative impact of different determinants for the inter-individual variations in POP-biomarkers.</p> <p>Method</p> <p>In study populations of 3161 adults, comprising Greenlandic Inuits, Swedish fishermen and their wives, and inhabitants from Warsaw, Poland and Kharkiv, Ukraine, serum concentrations of CB-153 and p,p'-DDE, were analysed by gas chromatography-mass spectrometry.</p> <p>Results</p> <p>The median serum concentrations of CB-153 were for male and female Inuits 200 and 110, for Swedish fishermen 190 and their wives 84, for Kharkiv men and women 44 and 27, and for Warsaw men and women 17 and 11 ng/g lipids, respectively. The median serum concentrations of p,p'-DDE were for Kharkiv men and women 930 and 650, for male and female Inuits 560 and 300, for Warsaw men and women 530 and 380, and for Swedish fishermen 240 and their wives 140 ng/g lipids, respectively. The correlation coefficients between CB-153 and p,p'-DDE varied between 0.19 and 0.92, with the highest correlation among Inuits and the lowest among men from Warsaw. Men had averagely higher serum concentrations of CB-153 and p,p'-DDE, and there were positive associations between age and the POP-biomarkers, whereas the associations with BMI and smoking were inconsistent. Dietary seafood was of importance only in the Inuit and Swedish populations.</p> <p>Conclusion</p> <p>CB-153 concentrations were much higher in Inuits and Swedish fishermen's populations than in the populations from Eastern Europe, whereas the pattern was different for p,p'-DDE showing highest concentrations in the Kharkiv population. The correlations between the POP-biomarkers varied considerably between the populations, underlining that exposure sources differ and that the choice of representative biomarkers of overall POP exposure has to be based on an analysis of the specific exposure situation for each population. Age and gender were consistent determinants of serum POPs; seafood was of importance only in the Inuit and Swedish populations.</p> |
| first_indexed | 2024-12-11T09:33:57Z |
| format | Article |
| id | doaj.art-56bb64c8183045679bd8b7ce030a178a |
| institution | Directory Open Access Journal |
| issn | 1476-069X |
| language | English |
| last_indexed | 2024-12-11T09:33:57Z |
| publishDate | 2005-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Environmental Health |
| spelling | doaj.art-56bb64c8183045679bd8b7ce030a178a2022-12-22T01:12:55ZengBMCEnvironmental Health1476-069X2005-11-01412710.1186/1476-069X-4-27Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (<it>p</it>-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populationsBonefeld-Jörgensen Eva CBizzaro DavideSpanò MarcelloZvyezday ValentynaGóralczyk KatarzynaLudwicki Jan KPedersen Henning SToft GunnarGiwercman AleksanderRignell-Hydbom AnnaLindh ChristianRylander LarsJönsson Bo AGManicardi GianBonde JensHagmar Lars<p>Abstract</p> <p>Background</p> <p>The study is part of a collaborative project (Inuendo), aiming to assess the impact of dietary persistent organochlorine pollutants (POPs) on human fertility. The aims with the present study are to analyze inter-population variations in serum concentrations of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (<it>p</it>-chlorophenyl)-ethylene (p,p'-DDE), to assess inter-population variations in biomarker correlations, and to evaluate the relative impact of different determinants for the inter-individual variations in POP-biomarkers.</p> <p>Method</p> <p>In study populations of 3161 adults, comprising Greenlandic Inuits, Swedish fishermen and their wives, and inhabitants from Warsaw, Poland and Kharkiv, Ukraine, serum concentrations of CB-153 and p,p'-DDE, were analysed by gas chromatography-mass spectrometry.</p> <p>Results</p> <p>The median serum concentrations of CB-153 were for male and female Inuits 200 and 110, for Swedish fishermen 190 and their wives 84, for Kharkiv men and women 44 and 27, and for Warsaw men and women 17 and 11 ng/g lipids, respectively. The median serum concentrations of p,p'-DDE were for Kharkiv men and women 930 and 650, for male and female Inuits 560 and 300, for Warsaw men and women 530 and 380, and for Swedish fishermen 240 and their wives 140 ng/g lipids, respectively. The correlation coefficients between CB-153 and p,p'-DDE varied between 0.19 and 0.92, with the highest correlation among Inuits and the lowest among men from Warsaw. Men had averagely higher serum concentrations of CB-153 and p,p'-DDE, and there were positive associations between age and the POP-biomarkers, whereas the associations with BMI and smoking were inconsistent. Dietary seafood was of importance only in the Inuit and Swedish populations.</p> <p>Conclusion</p> <p>CB-153 concentrations were much higher in Inuits and Swedish fishermen's populations than in the populations from Eastern Europe, whereas the pattern was different for p,p'-DDE showing highest concentrations in the Kharkiv population. The correlations between the POP-biomarkers varied considerably between the populations, underlining that exposure sources differ and that the choice of representative biomarkers of overall POP exposure has to be based on an analysis of the specific exposure situation for each population. Age and gender were consistent determinants of serum POPs; seafood was of importance only in the Inuit and Swedish populations.</p>http://www.ehjournal.net/content/4/1/27 |
| spellingShingle | Bonefeld-Jörgensen Eva C Bizzaro Davide Spanò Marcello Zvyezday Valentyna Góralczyk Katarzyna Ludwicki Jan K Pedersen Henning S Toft Gunnar Giwercman Aleksander Rignell-Hydbom Anna Lindh Christian Rylander Lars Jönsson Bo AG Manicardi Gian Bonde Jens Hagmar Lars Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (<it>p</it>-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations Environmental Health |
| title | Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (<it>p</it>-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations |
| title_full | Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (<it>p</it>-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations |
| title_fullStr | Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (<it>p</it>-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations |
| title_full_unstemmed | Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (<it>p</it>-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations |
| title_short | Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (<it>p</it>-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations |
| title_sort | inter population variations in concentrations determinants of and correlations between 2 2 4 4 5 5 hexachlorobiphenyl cb 153 and 1 1 dichloro 2 2 bis it p it chlorophenyl ethylene p p dde a cross sectional study of 3161 men and women from inuit and european populations |
| url | http://www.ehjournal.net/content/4/1/27 |
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