Neuroprotective Effects of Stachys Lavandulifolia Hydroalcoholic Extract on Size of Cerebral Ischemia, Blood-Brain Barrier Permeability and Edema Volume in Rat Stroke Model
Background and Aim: Recent studies point to the protective effects of Stachys lavandulifolia against inflammation and oxidative stress. The purpose of this study was to investigate the neuroprotective effects of Stachys lavandulifolia on brain injury, blood-brain barrier permeability and edema volum...
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| Format: | Article |
| Language: | fas |
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Arak Medical University
2019-02-01
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| Series: | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| Subjects: | |
| Online Access: | http://jams.arakmu.ac.ir/article-1-5765-en.pdf |
| _version_ | 1818690969595281408 |
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| author | Firoozeh Alavian Saeedeh Ghiasvand |
| author_facet | Firoozeh Alavian Saeedeh Ghiasvand |
| author_sort | Firoozeh Alavian |
| collection | DOAJ |
| description | Background and Aim: Recent studies point to the protective effects of Stachys lavandulifolia against inflammation and oxidative stress. The purpose of this study was to investigate the neuroprotective effects of Stachys lavandulifolia on brain injury, blood-brain barrier permeability and edema volume in rat stroke model.
Materials and Methods: In this experimental study, 17 male Wistar rats groups (n=6) were used; including control groups, sham and groups receiving doses of 50, 75 and 100 mg/kg/day of extract; for 30 days and orally by gavage. Two hours after the last gavage, the stroke groups were subjected to the Middle Cerebral Artery Occlusion (MCAO) model. 24 hours later, the volume of stroke, the blood-brain barrier permeability (BBB) and the volume of edema were investigated in the experimental groups. Results were analyzed by one-way ANOVA, Bonffron post test through Graph Pad Prism software and designed through Excel.
Ethical Considerations: This study with research ethics code IR.UI.REC.1397.162 has been approved by research ethics committee at Isfahan University.
Findings: Pre-treatment with Hydroalcoholic Extract with doses of 50, 75 and 100 mg/kg/day reduced stroke size. The dose of 75mg/kg/day reduced the permeability of BBB and the edema volume compared with the stroke group.
Conclusion: The most effective dose of Stachys lavandulifolia is 75 mg/kg, which has a strong potential in neuroprotection and stroke prevention. This study could be useful in further investigating of neuroprotective effect of Stachys lavandulifolia. |
| first_indexed | 2024-12-17T12:34:27Z |
| format | Article |
| id | doaj.art-56bcdd183716486ca49abbc75f4b6561 |
| institution | Directory Open Access Journal |
| issn | 1735-5338 2008-644X |
| language | fas |
| last_indexed | 2024-12-17T12:34:27Z |
| publishDate | 2019-02-01 |
| publisher | Arak Medical University |
| record_format | Article |
| series | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| spelling | doaj.art-56bcdd183716486ca49abbc75f4b65612022-12-21T21:48:24ZfasArak Medical UniversityMajallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk1735-53382008-644X2019-02-0121792101Neuroprotective Effects of Stachys Lavandulifolia Hydroalcoholic Extract on Size of Cerebral Ischemia, Blood-Brain Barrier Permeability and Edema Volume in Rat Stroke ModelFiroozeh Alavian0Saeedeh Ghiasvand1Department of Basic Sciences, Farhangian University, Tehran, Iran.Department of Basic Sciences, Malayer University, Malayer, Iran.Background and Aim: Recent studies point to the protective effects of Stachys lavandulifolia against inflammation and oxidative stress. The purpose of this study was to investigate the neuroprotective effects of Stachys lavandulifolia on brain injury, blood-brain barrier permeability and edema volume in rat stroke model. Materials and Methods: In this experimental study, 17 male Wistar rats groups (n=6) were used; including control groups, sham and groups receiving doses of 50, 75 and 100 mg/kg/day of extract; for 30 days and orally by gavage. Two hours after the last gavage, the stroke groups were subjected to the Middle Cerebral Artery Occlusion (MCAO) model. 24 hours later, the volume of stroke, the blood-brain barrier permeability (BBB) and the volume of edema were investigated in the experimental groups. Results were analyzed by one-way ANOVA, Bonffron post test through Graph Pad Prism software and designed through Excel. Ethical Considerations: This study with research ethics code IR.UI.REC.1397.162 has been approved by research ethics committee at Isfahan University. Findings: Pre-treatment with Hydroalcoholic Extract with doses of 50, 75 and 100 mg/kg/day reduced stroke size. The dose of 75mg/kg/day reduced the permeability of BBB and the edema volume compared with the stroke group. Conclusion: The most effective dose of Stachys lavandulifolia is 75 mg/kg, which has a strong potential in neuroprotection and stroke prevention. This study could be useful in further investigating of neuroprotective effect of Stachys lavandulifolia.http://jams.arakmu.ac.ir/article-1-5765-en.pdfNeuroprotectionRatStachys lavandulifoliaStroke |
| spellingShingle | Firoozeh Alavian Saeedeh Ghiasvand Neuroprotective Effects of Stachys Lavandulifolia Hydroalcoholic Extract on Size of Cerebral Ischemia, Blood-Brain Barrier Permeability and Edema Volume in Rat Stroke Model Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk Neuroprotection Rat Stachys lavandulifolia Stroke |
| title | Neuroprotective Effects of Stachys Lavandulifolia Hydroalcoholic Extract on Size of Cerebral Ischemia, Blood-Brain Barrier Permeability and Edema Volume in Rat Stroke Model |
| title_full | Neuroprotective Effects of Stachys Lavandulifolia Hydroalcoholic Extract on Size of Cerebral Ischemia, Blood-Brain Barrier Permeability and Edema Volume in Rat Stroke Model |
| title_fullStr | Neuroprotective Effects of Stachys Lavandulifolia Hydroalcoholic Extract on Size of Cerebral Ischemia, Blood-Brain Barrier Permeability and Edema Volume in Rat Stroke Model |
| title_full_unstemmed | Neuroprotective Effects of Stachys Lavandulifolia Hydroalcoholic Extract on Size of Cerebral Ischemia, Blood-Brain Barrier Permeability and Edema Volume in Rat Stroke Model |
| title_short | Neuroprotective Effects of Stachys Lavandulifolia Hydroalcoholic Extract on Size of Cerebral Ischemia, Blood-Brain Barrier Permeability and Edema Volume in Rat Stroke Model |
| title_sort | neuroprotective effects of stachys lavandulifolia hydroalcoholic extract on size of cerebral ischemia blood brain barrier permeability and edema volume in rat stroke model |
| topic | Neuroprotection Rat Stachys lavandulifolia Stroke |
| url | http://jams.arakmu.ac.ir/article-1-5765-en.pdf |
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