Age-Dependent Anti-migraine Effects of Valproic Acid and Topiramate in Rats

Age-Dependent Anti-migraine Effects of Valproic Acid and Topiramate in Rats

Background: Valproic acid (VPA) and topiramate (TPM), initially developed as antiepileptics, are approved for migraine prophylaxis in adults but not children. The differences in their antimigraine mechanism(s) by age remain unclear.Methods: A migraine model induced by intra-cisternal (i.c.) capsaici...

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Bibliographic Details
Main Authors: Pokai Huang, Ping-Hung Kuo, Ming Tatt Lee, Lih-Chu Chiou, Pi-Chuan Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Pharmacology
Subjects:
valproic acid
topiramate
age difference
migraine
CGRP
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01095/full

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