Scalable total synthesis of (+)-aniduquinolone A and its acid-catalyzed rearrangement to aflaquinolones

Quinolones can possess desirable antibacterial, antiviral and anticancer properties, rending them important synthetic targets for drug discovery purposes. Here, the gram-scale total synthesis of antiviral (+)-aniduquinolone A, possessing a 3,4-dioxygenated 5-hydroxy-4-aryl-quinolin-2(1H)-one skeleto...

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Bibliographic Details
Main Authors: Feng-Wei Guo, Xiao-Feng Mou, Yong Qu, Mei-Yan Wei, Guang-Ying Chen, Chang-Yun Wang, Yu-Cheng Gu, Chang-Lun Shao
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-022-00655-x

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