Scalable total synthesis of (+)-aniduquinolone A and its acid-catalyzed rearrangement to aflaquinolones
Quinolones can possess desirable antibacterial, antiviral and anticancer properties, rending them important synthetic targets for drug discovery purposes. Here, the gram-scale total synthesis of antiviral (+)-aniduquinolone A, possessing a 3,4-dioxygenated 5-hydroxy-4-aryl-quinolin-2(1H)-one skeleto...
Main Authors: | Feng-Wei Guo, Xiao-Feng Mou, Yong Qu, Mei-Yan Wei, Guang-Ying Chen, Chang-Yun Wang, Yu-Cheng Gu, Chang-Lun Shao |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-03-01
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Series: | Communications Chemistry |
Online Access: | https://doi.org/10.1038/s42004-022-00655-x |
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