Pharmacogenetic study of pruritus induced by epidural morphine for post cesarean section analgesia
Objective: The mechanism through which neuroaxial morphine causes pruritus has not been elucidated clearly and thoroughly. Materials and methods: a study in 129 female parturients was conducted to investigate the effect of 14 single nucleotide polymorphisms (SNPs) on phenotype (pruritus) induced by...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-02-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455917303091 |
| _version_ | 1819230880739098624 |
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| author | Chia-Chi Kung Shiou-Sheng Chen Hong-Jyh Yang Chih-Jun Lai Li-Kuei Chen |
| author_facet | Chia-Chi Kung Shiou-Sheng Chen Hong-Jyh Yang Chih-Jun Lai Li-Kuei Chen |
| author_sort | Chia-Chi Kung |
| collection | DOAJ |
| description | Objective: The mechanism through which neuroaxial morphine causes pruritus has not been elucidated clearly and thoroughly.
Materials and methods: a study in 129 female parturients was conducted to investigate the effect of 14 single nucleotide polymorphisms (SNPs) on phenotype (pruritus) induced by neuroaxial (including intrathecal or epidural) morphine for cesarean section. Clinical phenotype, subjective complaints and objective observations were recorded. DNA from blood samples was used to record the SNPs. Eleven SNPs were then analyzed further.
Results: no significant association with the presence of phenotype (pruritus) versus genotype was observed (all p-values > 0.05). No significant association with severity of phenotype versus genotype of the 11 SNPs was observed except for unadjusted data for rs2737703. There was no significant difference between severity or incidence of IVPCA morphine-induced nausea and vomiting and genotype (11 SNPs).
Conclusion: our results showed no association between SNPs of any of the genes studied with neuroaxial morphine inducing pruritus. |
| first_indexed | 2024-12-23T11:36:06Z |
| format | Article |
| id | doaj.art-56bfe44147aa4f9e9e469fa5b41dbe88 |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-23T11:36:06Z |
| publishDate | 2018-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-56bfe44147aa4f9e9e469fa5b41dbe882022-12-21T17:48:39ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592018-02-01571899410.1016/j.tjog.2017.12.015Pharmacogenetic study of pruritus induced by epidural morphine for post cesarean section analgesiaChia-Chi Kung0Shiou-Sheng Chen1Hong-Jyh Yang2Chih-Jun Lai3Li-Kuei Chen4Department of Anesthesiology, National Taiwan University Hospital Hsin- Chu Branch, Hsinchu City, 30059, TaiwanDepartment of Urology, School of Medicine, National Yang-Ming University, Taipei, 112, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital Hsin- Chu Branch, Hsinchu City, 30059, TaiwanDepartment of Anesthesiology, National Taiwan University Hospital Hsin- Chu Branch, Hsinchu City, 30059, TaiwanDepartment of Anesthesiology, National Taiwan University Hospital Hsin- Chu Branch, Hsinchu City, 30059, TaiwanObjective: The mechanism through which neuroaxial morphine causes pruritus has not been elucidated clearly and thoroughly. Materials and methods: a study in 129 female parturients was conducted to investigate the effect of 14 single nucleotide polymorphisms (SNPs) on phenotype (pruritus) induced by neuroaxial (including intrathecal or epidural) morphine for cesarean section. Clinical phenotype, subjective complaints and objective observations were recorded. DNA from blood samples was used to record the SNPs. Eleven SNPs were then analyzed further. Results: no significant association with the presence of phenotype (pruritus) versus genotype was observed (all p-values > 0.05). No significant association with severity of phenotype versus genotype of the 11 SNPs was observed except for unadjusted data for rs2737703. There was no significant difference between severity or incidence of IVPCA morphine-induced nausea and vomiting and genotype (11 SNPs). Conclusion: our results showed no association between SNPs of any of the genes studied with neuroaxial morphine inducing pruritus.http://www.sciencedirect.com/science/article/pii/S1028455917303091MorphineNeuroaxialPhenotypePruritisSingle nucleotide polymorphisms (SNPs) |
| spellingShingle | Chia-Chi Kung Shiou-Sheng Chen Hong-Jyh Yang Chih-Jun Lai Li-Kuei Chen Pharmacogenetic study of pruritus induced by epidural morphine for post cesarean section analgesia Taiwanese Journal of Obstetrics & Gynecology Morphine Neuroaxial Phenotype Pruritis Single nucleotide polymorphisms (SNPs) |
| title | Pharmacogenetic study of pruritus induced by epidural morphine for post cesarean section analgesia |
| title_full | Pharmacogenetic study of pruritus induced by epidural morphine for post cesarean section analgesia |
| title_fullStr | Pharmacogenetic study of pruritus induced by epidural morphine for post cesarean section analgesia |
| title_full_unstemmed | Pharmacogenetic study of pruritus induced by epidural morphine for post cesarean section analgesia |
| title_short | Pharmacogenetic study of pruritus induced by epidural morphine for post cesarean section analgesia |
| title_sort | pharmacogenetic study of pruritus induced by epidural morphine for post cesarean section analgesia |
| topic | Morphine Neuroaxial Phenotype Pruritis Single nucleotide polymorphisms (SNPs) |
| url | http://www.sciencedirect.com/science/article/pii/S1028455917303091 |
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