Etiopathogenesis of dermatitis herpetiformis.
Dermatitis herpetiformis is a rare chronic, autoimmune bullous disease linked to gluten sensitivity with intense pruritus and characteristic skin eruptions. Etiopathogenesis is complex and not fully understood. It is currently considered to be a specific cutaneous manifestation of celiac disease. Ge...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2022-02-01
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| Series: | Advances in Dermatology and Allergology |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Etiopathogenesis-of-dermatitis-herpetiformis-,7,42651,1,1.html |
| _version_ | 1811183048213921792 |
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| author | Joanna Rybak-d’Obyrn Waldemar Placek |
| author_facet | Joanna Rybak-d’Obyrn Waldemar Placek |
| author_sort | Joanna Rybak-d’Obyrn |
| collection | DOAJ |
| description | Dermatitis herpetiformis is a rare chronic, autoimmune bullous disease linked to gluten sensitivity with intense pruritus and characteristic skin eruptions. Etiopathogenesis is complex and not fully understood. It is currently considered to be a specific cutaneous manifestation of celiac disease. Genetic, environmental and immunological factors influence both conditions. Exposure to gluten is the starting point of an inflammatory cascade leading to the formation of circulating IgA antibodies against tissue transglutaminase and skin immune IgA deposition followed by skin lesions. Binding of the immune complex deposits of IgA transglutaminases and epidermal antibodies with enzymes in the papillary dermis stimulates complement activation, neutrophil influx, proinflammatory cytokine release and overproduction of matrix metalloproteinases. We have collected current knowledge of the pathogenesis of dermatitis herpetiformis. |
| first_indexed | 2024-04-11T09:40:58Z |
| format | Article |
| id | doaj.art-56bffc9ed70f47fd954112129b87ef99 |
| institution | Directory Open Access Journal |
| issn | 1642-395X 2299-0046 |
| language | English |
| last_indexed | 2024-04-11T09:40:58Z |
| publishDate | 2022-02-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Advances in Dermatology and Allergology |
| spelling | doaj.art-56bffc9ed70f47fd954112129b87ef992022-12-22T04:31:18ZengTermedia Publishing HouseAdvances in Dermatology and Allergology1642-395X2299-00462022-02-013911610.5114/ada.2020.10163742651Etiopathogenesis of dermatitis herpetiformis.Joanna Rybak-d’ObyrnWaldemar PlacekDermatitis herpetiformis is a rare chronic, autoimmune bullous disease linked to gluten sensitivity with intense pruritus and characteristic skin eruptions. Etiopathogenesis is complex and not fully understood. It is currently considered to be a specific cutaneous manifestation of celiac disease. Genetic, environmental and immunological factors influence both conditions. Exposure to gluten is the starting point of an inflammatory cascade leading to the formation of circulating IgA antibodies against tissue transglutaminase and skin immune IgA deposition followed by skin lesions. Binding of the immune complex deposits of IgA transglutaminases and epidermal antibodies with enzymes in the papillary dermis stimulates complement activation, neutrophil influx, proinflammatory cytokine release and overproduction of matrix metalloproteinases. We have collected current knowledge of the pathogenesis of dermatitis herpetiformis.https://www.termedia.pl/Etiopathogenesis-of-dermatitis-herpetiformis-,7,42651,1,1.htmldermatitis herpetiformis transglutaminases vesicobullous skin diseases |
| spellingShingle | Joanna Rybak-d’Obyrn Waldemar Placek Etiopathogenesis of dermatitis herpetiformis. Advances in Dermatology and Allergology dermatitis herpetiformis transglutaminases vesicobullous skin diseases |
| title | Etiopathogenesis of dermatitis herpetiformis. |
| title_full | Etiopathogenesis of dermatitis herpetiformis. |
| title_fullStr | Etiopathogenesis of dermatitis herpetiformis. |
| title_full_unstemmed | Etiopathogenesis of dermatitis herpetiformis. |
| title_short | Etiopathogenesis of dermatitis herpetiformis. |
| title_sort | etiopathogenesis of dermatitis herpetiformis |
| topic | dermatitis herpetiformis transglutaminases vesicobullous skin diseases |
| url | https://www.termedia.pl/Etiopathogenesis-of-dermatitis-herpetiformis-,7,42651,1,1.html |
| work_keys_str_mv | AT joannarybakdobyrn etiopathogenesisofdermatitisherpetiformis AT waldemarplacek etiopathogenesisofdermatitisherpetiformis |