Causal Relations Between Obstructive Sleep Apnea and Stroke: A Mendelian Randomization Study
Po Li,1 Zhiyong Dong,2 Wenhui Chen,2 Gang Yang1 1Department of General Surgery, Second People’s Hospital of Zhangye City, Zhangye, 734000, People’s Republic of China; 2Department of Gastrointestinal Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of ChinaCorr...
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Dove Medical Press
2023-04-01
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| Series: | Nature and Science of Sleep |
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| Online Access: | https://www.dovepress.com/causal-relations-between-obstructive-sleep-apnea-and-stroke-a-mendelia-peer-reviewed-fulltext-article-NSS |
| _version_ | 1797843372437667840 |
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| author | Li P Dong Z Chen W Yang G |
| author_facet | Li P Dong Z Chen W Yang G |
| author_sort | Li P |
| collection | DOAJ |
| description | Po Li,1 Zhiyong Dong,2 Wenhui Chen,2 Gang Yang1 1Department of General Surgery, Second People’s Hospital of Zhangye City, Zhangye, 734000, People’s Republic of China; 2Department of Gastrointestinal Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of ChinaCorrespondence: Gang Yang, Department of General Surgery, Second People’s Hospital of Zhangye City, No. 270 Linsong West Street, Binhe New District, Ganzhou District, Zhangye, Gansu, People’s Republic of China, Tel +86 1899361927, Fax +0936 8215086, Email yg8755@126.com Wenhui Chen, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Jinan University, No. 613 Huangpu Avenue West, Guangzhou, People’s Republic of China, Tel +86 13129349492, Fax +86 20 38688608, Email jnucwh2019@163.comBackground: Previous studies of obstructive sleep apnea (OSA) in relation to stroke have been noted. However, the exact causality remains to be clearly defined. We aimed to adopt a two-sample Mendelian randomization study to investigate the causal effects of OSA on stroke and its subtypes.Methods: A two-sample Mendelian randomization (MR) analysis was conducted to evaluate the causal effect of OSA on stroke and its subtypes, including, based on publicly genome-wide association studies (GWAS) databases. The inverse variance weighted (IVW) method was used as the main analysis. MR-Egger regression, weighted mode, weighted median, and MR pleiotropy residual sum and outlier (MR-PRESSO) were performed methods and were adopted as supplementary analysis to ensure the robustness of the results.Results: Genetically predicted OSA was not related to the risk of stroke (odds ratio (OR), 0.99, 95% CI, 0.81– 1.21, p = 0.909), and its subtypes, ischemic stroke (IS) (OR, 1.01, 95% CI, 0.82– 1.23, p = 0.927), large vessel stroke (LVS) (OR, 1.05, 95% CI, 0.73– 1.51, p = 0.795), cardioembolic stroke (CES) (OR, 1.03, 95% CI, 0.74– 1.43, p = 0.855), small vessel stroke (SVS) (OR, 1.13, 95% CI, 0.88– 1.46, p = 0.329), lacunar stroke (LS) (OR, 1.07, 95% CI, 0.74– 1.56, p = 0.721) as well as intracerebral hemorrhage (ICH) (OR, 0.37, 95% CI = 0.09, 1.48, p = 0.160) (Wald ratio method). Other supplementary MR methods also confirmed similar results.Conclusion: There may be no direct causal relationship between OSA and stroke or its subtypes.Keywords: obstructive sleep apnea, stroke, Mendelian randomization, causal association |
| first_indexed | 2024-04-09T17:04:05Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1179-1608 |
| language | English |
| last_indexed | 2024-04-09T17:04:05Z |
| publishDate | 2023-04-01 |
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| series | Nature and Science of Sleep |
| spelling | doaj.art-56c0b417e4ce4d2dbc236c1ba134a7562023-04-20T18:42:14ZengDove Medical PressNature and Science of Sleep1179-16082023-04-01Volume 1525726683150Causal Relations Between Obstructive Sleep Apnea and Stroke: A Mendelian Randomization StudyLi PDong ZChen WYang GPo Li,1 Zhiyong Dong,2 Wenhui Chen,2 Gang Yang1 1Department of General Surgery, Second People’s Hospital of Zhangye City, Zhangye, 734000, People’s Republic of China; 2Department of Gastrointestinal Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of ChinaCorrespondence: Gang Yang, Department of General Surgery, Second People’s Hospital of Zhangye City, No. 270 Linsong West Street, Binhe New District, Ganzhou District, Zhangye, Gansu, People’s Republic of China, Tel +86 1899361927, Fax +0936 8215086, Email yg8755@126.com Wenhui Chen, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Jinan University, No. 613 Huangpu Avenue West, Guangzhou, People’s Republic of China, Tel +86 13129349492, Fax +86 20 38688608, Email jnucwh2019@163.comBackground: Previous studies of obstructive sleep apnea (OSA) in relation to stroke have been noted. However, the exact causality remains to be clearly defined. We aimed to adopt a two-sample Mendelian randomization study to investigate the causal effects of OSA on stroke and its subtypes.Methods: A two-sample Mendelian randomization (MR) analysis was conducted to evaluate the causal effect of OSA on stroke and its subtypes, including, based on publicly genome-wide association studies (GWAS) databases. The inverse variance weighted (IVW) method was used as the main analysis. MR-Egger regression, weighted mode, weighted median, and MR pleiotropy residual sum and outlier (MR-PRESSO) were performed methods and were adopted as supplementary analysis to ensure the robustness of the results.Results: Genetically predicted OSA was not related to the risk of stroke (odds ratio (OR), 0.99, 95% CI, 0.81– 1.21, p = 0.909), and its subtypes, ischemic stroke (IS) (OR, 1.01, 95% CI, 0.82– 1.23, p = 0.927), large vessel stroke (LVS) (OR, 1.05, 95% CI, 0.73– 1.51, p = 0.795), cardioembolic stroke (CES) (OR, 1.03, 95% CI, 0.74– 1.43, p = 0.855), small vessel stroke (SVS) (OR, 1.13, 95% CI, 0.88– 1.46, p = 0.329), lacunar stroke (LS) (OR, 1.07, 95% CI, 0.74– 1.56, p = 0.721) as well as intracerebral hemorrhage (ICH) (OR, 0.37, 95% CI = 0.09, 1.48, p = 0.160) (Wald ratio method). Other supplementary MR methods also confirmed similar results.Conclusion: There may be no direct causal relationship between OSA and stroke or its subtypes.Keywords: obstructive sleep apnea, stroke, Mendelian randomization, causal associationhttps://www.dovepress.com/causal-relations-between-obstructive-sleep-apnea-and-stroke-a-mendelia-peer-reviewed-fulltext-article-NSSobstructive sleep apneastrokemendelian randomizationcausal association. |
| spellingShingle | Li P Dong Z Chen W Yang G Causal Relations Between Obstructive Sleep Apnea and Stroke: A Mendelian Randomization Study Nature and Science of Sleep obstructive sleep apnea stroke mendelian randomization causal association. |
| title | Causal Relations Between Obstructive Sleep Apnea and Stroke: A Mendelian Randomization Study |
| title_full | Causal Relations Between Obstructive Sleep Apnea and Stroke: A Mendelian Randomization Study |
| title_fullStr | Causal Relations Between Obstructive Sleep Apnea and Stroke: A Mendelian Randomization Study |
| title_full_unstemmed | Causal Relations Between Obstructive Sleep Apnea and Stroke: A Mendelian Randomization Study |
| title_short | Causal Relations Between Obstructive Sleep Apnea and Stroke: A Mendelian Randomization Study |
| title_sort | causal relations between obstructive sleep apnea and stroke a mendelian randomization study |
| topic | obstructive sleep apnea stroke mendelian randomization causal association. |
| url | https://www.dovepress.com/causal-relations-between-obstructive-sleep-apnea-and-stroke-a-mendelia-peer-reviewed-fulltext-article-NSS |
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