Association of Antiplatelet Therapy, Including Cilostazol, With Improved Survival in Patients With Moyamoya Disease in a Nationwide Study
Background Although antiplatelet agents are frequently prescribed in moyamoya disease in routine clinical practice, there are no large‐scale epidemiologic trials or randomized trial evidence to support their use in patients with moyamoya disease. Methods and Results Using the Korean National Health...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-03-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.120.017701 |
| _version_ | 1818775113901801472 |
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| author | Woo‐Keun Seo Jae‐Young Kim Eun‐Hyeok Choi Ye‐Sel Kim Jong‐Won Chung Jeffrey L. Saver Oh Young Bang Gyeong‐Moon Kim |
| author_facet | Woo‐Keun Seo Jae‐Young Kim Eun‐Hyeok Choi Ye‐Sel Kim Jong‐Won Chung Jeffrey L. Saver Oh Young Bang Gyeong‐Moon Kim |
| author_sort | Woo‐Keun Seo |
| collection | DOAJ |
| description | Background Although antiplatelet agents are frequently prescribed in moyamoya disease in routine clinical practice, there are no large‐scale epidemiologic trials or randomized trial evidence to support their use in patients with moyamoya disease. Methods and Results Using the Korean National Health Insurance Service database, patients diagnosed with moyamoya disease between 2002 and 2016 were followed up for up to 14 years to assess, using time‐dependent Cox regression in all patients and in a propensity score–matched cohort, the association of antiplatelet therapy and individual antiplatelet agents with survival. Among 25 978 patients with newly diagnosed moyamoya disease, mean age was 37.6±19.9 years, 61.6% were women, and total follow‐up was 163 347 person‐years. Among 9154 patients who were prescribed antiplatelet agents at least once during the follow‐up period, the proportion prescribed cilostazol gradually increased from 5.5% in 2002 to 56.0% in 2016. Any antiplatelet use was associated with reduced risk of death (hazard ratio, 0.77; 95% CI, 0.70–0.84) in a multivariate model. Among individual antiplatelet agents, cilostazol was associated with greater reduction in mortality than the 5 other antiplatelet regimens. Subgroup analysis, according to the age group and history of ischemic stroke, and sensitivity analysis, using propensity score–matched analysis, revealed consistent results. Conclusions Antiplatelet therapy is associated with substantial improvement in survival in patients with moyamoya disease, and cilostazol is associated with greater survival benefit compared with other antiplatelet regimens. These results provisionally support the use of antiplatelet therapy in patients with moyamoya disease and the conduct of confirmatory randomized controlled trials. |
| first_indexed | 2024-12-18T10:51:53Z |
| format | Article |
| id | doaj.art-56c0b9e0a42343ceaab12ca442400734 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-18T10:51:53Z |
| publishDate | 2021-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-56c0b9e0a42343ceaab12ca4424007342022-12-21T21:10:26ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802021-03-0110510.1161/JAHA.120.017701Association of Antiplatelet Therapy, Including Cilostazol, With Improved Survival in Patients With Moyamoya Disease in a Nationwide StudyWoo‐Keun Seo0Jae‐Young Kim1Eun‐Hyeok Choi2Ye‐Sel Kim3Jong‐Won Chung4Jeffrey L. Saver5Oh Young Bang6Gyeong‐Moon Kim7Department of Neurology and Stroke Center Samsung Medical Center Seoul KoreaDepartment of Neurology and Stroke Center Samsung Medical Center Seoul KoreaDepartment of Neurology and Stroke Center Samsung Medical Center Seoul KoreaDepartment of Neurology and Stroke Center Samsung Medical Center Seoul KoreaDepartment of Neurology and Stroke Center Samsung Medical Center Seoul KoreaDepartment of Digital Health Samsung Advanced Institute for Health Sciences & TechnologySungkyunkwan University Seoul KoreaDepartment of Neurology and Stroke Center Samsung Medical Center Seoul KoreaDepartment of Neurology and Stroke Center Samsung Medical Center Seoul KoreaBackground Although antiplatelet agents are frequently prescribed in moyamoya disease in routine clinical practice, there are no large‐scale epidemiologic trials or randomized trial evidence to support their use in patients with moyamoya disease. Methods and Results Using the Korean National Health Insurance Service database, patients diagnosed with moyamoya disease between 2002 and 2016 were followed up for up to 14 years to assess, using time‐dependent Cox regression in all patients and in a propensity score–matched cohort, the association of antiplatelet therapy and individual antiplatelet agents with survival. Among 25 978 patients with newly diagnosed moyamoya disease, mean age was 37.6±19.9 years, 61.6% were women, and total follow‐up was 163 347 person‐years. Among 9154 patients who were prescribed antiplatelet agents at least once during the follow‐up period, the proportion prescribed cilostazol gradually increased from 5.5% in 2002 to 56.0% in 2016. Any antiplatelet use was associated with reduced risk of death (hazard ratio, 0.77; 95% CI, 0.70–0.84) in a multivariate model. Among individual antiplatelet agents, cilostazol was associated with greater reduction in mortality than the 5 other antiplatelet regimens. Subgroup analysis, according to the age group and history of ischemic stroke, and sensitivity analysis, using propensity score–matched analysis, revealed consistent results. Conclusions Antiplatelet therapy is associated with substantial improvement in survival in patients with moyamoya disease, and cilostazol is associated with greater survival benefit compared with other antiplatelet regimens. These results provisionally support the use of antiplatelet therapy in patients with moyamoya disease and the conduct of confirmatory randomized controlled trials.https://www.ahajournals.org/doi/10.1161/JAHA.120.017701antiplatelet agentcilostazolmoyamoya diseasestrokesurvival |
| spellingShingle | Woo‐Keun Seo Jae‐Young Kim Eun‐Hyeok Choi Ye‐Sel Kim Jong‐Won Chung Jeffrey L. Saver Oh Young Bang Gyeong‐Moon Kim Association of Antiplatelet Therapy, Including Cilostazol, With Improved Survival in Patients With Moyamoya Disease in a Nationwide Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease antiplatelet agent cilostazol moyamoya disease stroke survival |
| title | Association of Antiplatelet Therapy, Including Cilostazol, With Improved Survival in Patients With Moyamoya Disease in a Nationwide Study |
| title_full | Association of Antiplatelet Therapy, Including Cilostazol, With Improved Survival in Patients With Moyamoya Disease in a Nationwide Study |
| title_fullStr | Association of Antiplatelet Therapy, Including Cilostazol, With Improved Survival in Patients With Moyamoya Disease in a Nationwide Study |
| title_full_unstemmed | Association of Antiplatelet Therapy, Including Cilostazol, With Improved Survival in Patients With Moyamoya Disease in a Nationwide Study |
| title_short | Association of Antiplatelet Therapy, Including Cilostazol, With Improved Survival in Patients With Moyamoya Disease in a Nationwide Study |
| title_sort | association of antiplatelet therapy including cilostazol with improved survival in patients with moyamoya disease in a nationwide study |
| topic | antiplatelet agent cilostazol moyamoya disease stroke survival |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.120.017701 |
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