Thrombotic gene polymorphisms and postoperative outcome after coronary artery bypass graft surgery
<p>Abstract</p> <p>Background</p> <p>Emerging perioperative genomics may influence the direction of risk assessment and surgical strategies in cardiac surgery. The aim of this study was to investigate whether single nucleotide polymorphisms (SNP) affect the clinical pre...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-09-01
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| Series: | Journal of Cardiothoracic Surgery |
| Online Access: | http://www.cardiothoracicsurgery.org/content/6/1/120 |
| _version_ | 1819140238630453248 |
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| author | Zaim Cagin Alakoc Yesim D Akar Ahmet R Egin Yonca Durdu Serkan Emiroglu Ozan Ozyurda Umit Akar Nejat |
| author_facet | Zaim Cagin Alakoc Yesim D Akar Ahmet R Egin Yonca Durdu Serkan Emiroglu Ozan Ozyurda Umit Akar Nejat |
| author_sort | Zaim Cagin |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Emerging perioperative genomics may influence the direction of risk assessment and surgical strategies in cardiac surgery. The aim of this study was to investigate whether single nucleotide polymorphisms (SNP) affect the clinical presentation and predispose to increased risk for postoperative adverse events in patients undergoing coronary artery bypass grafting surgery (CABG).</p> <p>Methods</p> <p>A total of 220 patients undergoing first-time CABG between January 2005 and May 2008 were screened for factor V gene G1691A (FVL), prothrombin/factor II G20210A (PT G20210A), angiotensin I-converting enzyme insertion/deletion (ACE-ins/del) polymorphisms by PCR and Real Time PCR. End points were defined as death, myocardial infarction, stroke, postoperative bleeding, respiratory and renal insufficiency and event-free survival. Patients were compared to assess for any independent association between genotypes for thrombosis and postoperative phenotypes.</p> <p>Results</p> <p>Among 220 patients, the prevalence of the heterozygous FVL mutation was 10.9% (n = 24), and 3.6% (n = 8) were heterozygous carriers of the PT G20210A mutation. Genotype distribution of ACE-ins/del was 16.6%, 51.9%, and 31.5% in genotypes I/I, I/D, and D/D, respectively. FVL and PT G20210A mutations were associated with higher prevalence of totally occluded coronary arteries (p < 0.001). Furthermore the risk of left ventricular aneurysm formation was significantly higher in FVL heterozygote group compared to FVL G1691G (<it>p </it>= 0.002). ACE D/D genotype was associated with hypertension (<it>p </it>= 0.004), peripheral vascular disease (p = 0.006), and previous myocardial infarction (<it>p </it>= 0.007).</p> <p>Conclusions</p> <p>FVL and PT G20210A genotypes had a higher prevalence of totally occluded vessels potentially as a result of atherothrombotic events. However, none of the genotypes investigated were independently associated with mortality.</p> |
| first_indexed | 2024-12-22T11:35:23Z |
| format | Article |
| id | doaj.art-56c3bea257e24e38aed033e33c76efef |
| institution | Directory Open Access Journal |
| issn | 1749-8090 |
| language | English |
| last_indexed | 2024-12-22T11:35:23Z |
| publishDate | 2011-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj.art-56c3bea257e24e38aed033e33c76efef2022-12-21T18:27:26ZengBMCJournal of Cardiothoracic Surgery1749-80902011-09-016112010.1186/1749-8090-6-120Thrombotic gene polymorphisms and postoperative outcome after coronary artery bypass graft surgeryZaim CaginAlakoc Yesim DAkar Ahmet REgin YoncaDurdu SerkanEmiroglu OzanOzyurda UmitAkar Nejat<p>Abstract</p> <p>Background</p> <p>Emerging perioperative genomics may influence the direction of risk assessment and surgical strategies in cardiac surgery. The aim of this study was to investigate whether single nucleotide polymorphisms (SNP) affect the clinical presentation and predispose to increased risk for postoperative adverse events in patients undergoing coronary artery bypass grafting surgery (CABG).</p> <p>Methods</p> <p>A total of 220 patients undergoing first-time CABG between January 2005 and May 2008 were screened for factor V gene G1691A (FVL), prothrombin/factor II G20210A (PT G20210A), angiotensin I-converting enzyme insertion/deletion (ACE-ins/del) polymorphisms by PCR and Real Time PCR. End points were defined as death, myocardial infarction, stroke, postoperative bleeding, respiratory and renal insufficiency and event-free survival. Patients were compared to assess for any independent association between genotypes for thrombosis and postoperative phenotypes.</p> <p>Results</p> <p>Among 220 patients, the prevalence of the heterozygous FVL mutation was 10.9% (n = 24), and 3.6% (n = 8) were heterozygous carriers of the PT G20210A mutation. Genotype distribution of ACE-ins/del was 16.6%, 51.9%, and 31.5% in genotypes I/I, I/D, and D/D, respectively. FVL and PT G20210A mutations were associated with higher prevalence of totally occluded coronary arteries (p < 0.001). Furthermore the risk of left ventricular aneurysm formation was significantly higher in FVL heterozygote group compared to FVL G1691G (<it>p </it>= 0.002). ACE D/D genotype was associated with hypertension (<it>p </it>= 0.004), peripheral vascular disease (p = 0.006), and previous myocardial infarction (<it>p </it>= 0.007).</p> <p>Conclusions</p> <p>FVL and PT G20210A genotypes had a higher prevalence of totally occluded vessels potentially as a result of atherothrombotic events. However, none of the genotypes investigated were independently associated with mortality.</p>http://www.cardiothoracicsurgery.org/content/6/1/120 |
| spellingShingle | Zaim Cagin Alakoc Yesim D Akar Ahmet R Egin Yonca Durdu Serkan Emiroglu Ozan Ozyurda Umit Akar Nejat Thrombotic gene polymorphisms and postoperative outcome after coronary artery bypass graft surgery Journal of Cardiothoracic Surgery |
| title | Thrombotic gene polymorphisms and postoperative outcome after coronary artery bypass graft surgery |
| title_full | Thrombotic gene polymorphisms and postoperative outcome after coronary artery bypass graft surgery |
| title_fullStr | Thrombotic gene polymorphisms and postoperative outcome after coronary artery bypass graft surgery |
| title_full_unstemmed | Thrombotic gene polymorphisms and postoperative outcome after coronary artery bypass graft surgery |
| title_short | Thrombotic gene polymorphisms and postoperative outcome after coronary artery bypass graft surgery |
| title_sort | thrombotic gene polymorphisms and postoperative outcome after coronary artery bypass graft surgery |
| url | http://www.cardiothoracicsurgery.org/content/6/1/120 |
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