The number of CD34+CD38+CD117+HLA-DR+CD13+CD33+ cells indicates post-chemotherapy hematopoietic recovery in patients with acute myeloid leukemia.
Hematopoietic recovery is considered to be associated with the number of multipotent hematopoietic stem cells in the bone marrow, as observed in functional assays involving stem cell transplantation. However, there is little evidence related to hematopoietic recovery in non-transplantation settings,...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5498054?pdf=render |
| _version_ | 1818034491183071232 |
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| author | Runxia Gu Hui Wei Ying Wang Dong Lin Bingcheng Liu Chunlin Zhou Kaiqi Liu Benfa Gong Shuning Wei Guangji Zhang Xiaoyuan Gong Yuntao Liu Yan Li Xingli Zhao Shaowei Qiu Huijun Wang Min Wang Yingchang Mi Jianxiang Wang |
| author_facet | Runxia Gu Hui Wei Ying Wang Dong Lin Bingcheng Liu Chunlin Zhou Kaiqi Liu Benfa Gong Shuning Wei Guangji Zhang Xiaoyuan Gong Yuntao Liu Yan Li Xingli Zhao Shaowei Qiu Huijun Wang Min Wang Yingchang Mi Jianxiang Wang |
| author_sort | Runxia Gu |
| collection | DOAJ |
| description | Hematopoietic recovery is considered to be associated with the number of multipotent hematopoietic stem cells in the bone marrow, as observed in functional assays involving stem cell transplantation. However, there is little evidence related to hematopoietic recovery in non-transplantation settings, which is accomplished by endogenous hematopoietic cells. A recent study suggested that progenitors are the main contributors during this steady-state hematopoiesis, which differs from exogenous transplantation. We hypothesized that endogenous progenitor support post-chemotherapy hematopoietic recovery. To investigate the potential impact of these progenitor cell percentage on hematopoietic recovery, we retrospectively analyzed the percentage of CD34+CD38+CD117+HLA-DR+CD13+CD33+ cells (P cells) and hematopoietic recovery in 223 newly diagnosed acute myeloid leukemia patients during two courses of consolidation chemotherapy after complete remission. We found that a lower P cell percentage was significantly associated with prolonged neutropenia recovery time after the first and second courses of consolidation chemotherapy (p = 0.001; p = 0.045, respectively). We also observed similar results with regard to platelet recovery time after the first course of consolidation chemotherapy (p = 0.000). Univariate analysis showed that P cell percentage and consolidation chemotherapy regimens, and not gender, age, induction chemotherapy regimens, infection grade, WHO classification and NCCN risk category, were associated with neutrophil recovery after chemotherapy. Multivariate analysis demonstrated that P cell percentage is an independent factor affecting neutrophil recovery capacity for both the first and second courses (p = 0.008; p = 0.032, respectively). Our results indicate that CD34+CD38+CD117+HLA-DR+CD13+CD33+ cells before each course of chemotherapy is independently associated with chemotherapy-related hematopoietic reconstitution capacity. These findings may help modify future chemotherapy regimens based on progenitor cell percentages. |
| first_indexed | 2024-12-10T06:40:00Z |
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| id | doaj.art-56c6af9d52384e05bdaf6fef1bbc4cb8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T06:40:00Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
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| spelling | doaj.art-56c6af9d52384e05bdaf6fef1bbc4cb82022-12-22T01:58:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01127e018062410.1371/journal.pone.0180624The number of CD34+CD38+CD117+HLA-DR+CD13+CD33+ cells indicates post-chemotherapy hematopoietic recovery in patients with acute myeloid leukemia.Runxia GuHui WeiYing WangDong LinBingcheng LiuChunlin ZhouKaiqi LiuBenfa GongShuning WeiGuangji ZhangXiaoyuan GongYuntao LiuYan LiXingli ZhaoShaowei QiuHuijun WangMin WangYingchang MiJianxiang WangHematopoietic recovery is considered to be associated with the number of multipotent hematopoietic stem cells in the bone marrow, as observed in functional assays involving stem cell transplantation. However, there is little evidence related to hematopoietic recovery in non-transplantation settings, which is accomplished by endogenous hematopoietic cells. A recent study suggested that progenitors are the main contributors during this steady-state hematopoiesis, which differs from exogenous transplantation. We hypothesized that endogenous progenitor support post-chemotherapy hematopoietic recovery. To investigate the potential impact of these progenitor cell percentage on hematopoietic recovery, we retrospectively analyzed the percentage of CD34+CD38+CD117+HLA-DR+CD13+CD33+ cells (P cells) and hematopoietic recovery in 223 newly diagnosed acute myeloid leukemia patients during two courses of consolidation chemotherapy after complete remission. We found that a lower P cell percentage was significantly associated with prolonged neutropenia recovery time after the first and second courses of consolidation chemotherapy (p = 0.001; p = 0.045, respectively). We also observed similar results with regard to platelet recovery time after the first course of consolidation chemotherapy (p = 0.000). Univariate analysis showed that P cell percentage and consolidation chemotherapy regimens, and not gender, age, induction chemotherapy regimens, infection grade, WHO classification and NCCN risk category, were associated with neutrophil recovery after chemotherapy. Multivariate analysis demonstrated that P cell percentage is an independent factor affecting neutrophil recovery capacity for both the first and second courses (p = 0.008; p = 0.032, respectively). Our results indicate that CD34+CD38+CD117+HLA-DR+CD13+CD33+ cells before each course of chemotherapy is independently associated with chemotherapy-related hematopoietic reconstitution capacity. These findings may help modify future chemotherapy regimens based on progenitor cell percentages.http://europepmc.org/articles/PMC5498054?pdf=render |
| spellingShingle | Runxia Gu Hui Wei Ying Wang Dong Lin Bingcheng Liu Chunlin Zhou Kaiqi Liu Benfa Gong Shuning Wei Guangji Zhang Xiaoyuan Gong Yuntao Liu Yan Li Xingli Zhao Shaowei Qiu Huijun Wang Min Wang Yingchang Mi Jianxiang Wang The number of CD34+CD38+CD117+HLA-DR+CD13+CD33+ cells indicates post-chemotherapy hematopoietic recovery in patients with acute myeloid leukemia. PLoS ONE |
| title | The number of CD34+CD38+CD117+HLA-DR+CD13+CD33+ cells indicates post-chemotherapy hematopoietic recovery in patients with acute myeloid leukemia. |
| title_full | The number of CD34+CD38+CD117+HLA-DR+CD13+CD33+ cells indicates post-chemotherapy hematopoietic recovery in patients with acute myeloid leukemia. |
| title_fullStr | The number of CD34+CD38+CD117+HLA-DR+CD13+CD33+ cells indicates post-chemotherapy hematopoietic recovery in patients with acute myeloid leukemia. |
| title_full_unstemmed | The number of CD34+CD38+CD117+HLA-DR+CD13+CD33+ cells indicates post-chemotherapy hematopoietic recovery in patients with acute myeloid leukemia. |
| title_short | The number of CD34+CD38+CD117+HLA-DR+CD13+CD33+ cells indicates post-chemotherapy hematopoietic recovery in patients with acute myeloid leukemia. |
| title_sort | number of cd34 cd38 cd117 hla dr cd13 cd33 cells indicates post chemotherapy hematopoietic recovery in patients with acute myeloid leukemia |
| url | http://europepmc.org/articles/PMC5498054?pdf=render |
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