Poisoning of amino- and nitrocompounds of benzene |in occupational pathology
Amino- and nitrocompounds of benzene belong to the group of blood poisons. They lead to the formation of pathological hemoglobin compounds in the blood. Methemoglobin is formed during poisoning of amino- and nitrocompounds of benzene. In severe cases of poisoning there is an irreversible compound —...
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| Format: | Article |
| Language: | English |
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Zaslavsky O.Yu.
2022-05-01
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| Series: | Медицина неотложных состояний |
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| Online Access: | https://emergency.zaslavsky.com.ua/index.php/journal/article/view/1487 |
| _version_ | 1811154259236880384 |
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| author | V.S. Tkachyshyn |
| author_facet | V.S. Tkachyshyn |
| author_sort | V.S. Tkachyshyn |
| collection | DOAJ |
| description | Amino- and nitrocompounds of benzene belong to the group of blood poisons. They lead to the formation of pathological hemoglobin compounds in the blood. Methemoglobin is formed during poisoning of amino- and nitrocompounds of benzene. In severe cases of poisoning there is an irreversible compound — sulfhemoglobin. Depending on the concentration and duration of contact, the amino- and nitrocompounds of benzene cause acute and chronic intoxication. Acute intoxication with these substances leads mainly to the formation of methemoglobin, secondary hemolytic anemia, damage to the central nervous system. When exposed to amino- and nitrocompounds of benzene, there are also signs of damage to the peripheral nervous system, liver, urinary tract, visual organ, skin and mucous membranes of the respiratory tract. Chronic intoxications with amino- and nitrocompounds of benzene lead to damage to the nervous system, parenchymal organs, mainly the liver, urinary tract, organ of vision. In chronic lesions, these compounds are carcinogenic. Bladder cancer is occurs. The antidote for poisoning by these substances is methylene blue, which is administered in 10–20 ml of 1% solution intravenously. Intravenous administration of 20–30 ml of 40% glucose solution is important. Oxygen therapy is also performed. In case of acute renal failure, hemodialysis or peritoneal dialysis is performed. Profilaxis is important to prevent poisoning. |
| first_indexed | 2024-04-10T04:12:38Z |
| format | Article |
| id | doaj.art-56c7149216bd4b32820b8a75e9776486 |
| institution | Directory Open Access Journal |
| issn | 2224-0586 2307-1230 |
| language | English |
| last_indexed | 2024-04-10T04:12:38Z |
| publishDate | 2022-05-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Медицина неотложных состояний |
| spelling | doaj.art-56c7149216bd4b32820b8a75e97764862023-03-12T14:46:46ZengZaslavsky O.Yu.Медицина неотложных состояний2224-05862307-12302022-05-01183313510.22141/2224-0586.18.3.2022.14871487Poisoning of amino- and nitrocompounds of benzene |in occupational pathologyV.S. Tkachyshyn0Національний медичний університет імені О.О. Богомольця, м. Київ, УкраїнаAmino- and nitrocompounds of benzene belong to the group of blood poisons. They lead to the formation of pathological hemoglobin compounds in the blood. Methemoglobin is formed during poisoning of amino- and nitrocompounds of benzene. In severe cases of poisoning there is an irreversible compound — sulfhemoglobin. Depending on the concentration and duration of contact, the amino- and nitrocompounds of benzene cause acute and chronic intoxication. Acute intoxication with these substances leads mainly to the formation of methemoglobin, secondary hemolytic anemia, damage to the central nervous system. When exposed to amino- and nitrocompounds of benzene, there are also signs of damage to the peripheral nervous system, liver, urinary tract, visual organ, skin and mucous membranes of the respiratory tract. Chronic intoxications with amino- and nitrocompounds of benzene lead to damage to the nervous system, parenchymal organs, mainly the liver, urinary tract, organ of vision. In chronic lesions, these compounds are carcinogenic. Bladder cancer is occurs. The antidote for poisoning by these substances is methylene blue, which is administered in 10–20 ml of 1% solution intravenously. Intravenous administration of 20–30 ml of 40% glucose solution is important. Oxygen therapy is also performed. In case of acute renal failure, hemodialysis or peritoneal dialysis is performed. Profilaxis is important to prevent poisoning.https://emergency.zaslavsky.com.ua/index.php/journal/article/view/1487amino- and nitrocompounds of benzeneblood poisonsmethemoglobinsulfhemoglobinacute and chronic intoxicationsmethylene blue |
| spellingShingle | V.S. Tkachyshyn Poisoning of amino- and nitrocompounds of benzene |in occupational pathology Медицина неотложных состояний amino- and nitrocompounds of benzene blood poisons methemoglobin sulfhemoglobin acute and chronic intoxications methylene blue |
| title | Poisoning of amino- and nitrocompounds of benzene |in occupational pathology |
| title_full | Poisoning of amino- and nitrocompounds of benzene |in occupational pathology |
| title_fullStr | Poisoning of amino- and nitrocompounds of benzene |in occupational pathology |
| title_full_unstemmed | Poisoning of amino- and nitrocompounds of benzene |in occupational pathology |
| title_short | Poisoning of amino- and nitrocompounds of benzene |in occupational pathology |
| title_sort | poisoning of amino and nitrocompounds of benzene in occupational pathology |
| topic | amino- and nitrocompounds of benzene blood poisons methemoglobin sulfhemoglobin acute and chronic intoxications methylene blue |
| url | https://emergency.zaslavsky.com.ua/index.php/journal/article/view/1487 |
| work_keys_str_mv | AT vstkachyshyn poisoningofaminoandnitrocompoundsofbenzeneinoccupationalpathology |