Clinical and Electrophysiological Evaluation of Neonatal Seizures
Neonatal seizures are the most prevalent and distinctive sign of neurologic dysfunction in early-life. In spite the recent advances in medical care and technology in newborn intensive care units (NICU), it remains an important clinical issue of diagnosis, treatment, and prognosis. This was a retrosp...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2023-12-01
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| Series: | The Journal of Pediatric Academy |
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| Online Access: | https://jpediatricacademy.com/index.php/jpa/article/view/247 |
| _version_ | 1797362321739218944 |
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| author | Mustafa Alper Aykanat Ünal Akça Gülfer Akça Hasibe Canan Seren Hamit Özyürek |
| author_facet | Mustafa Alper Aykanat Ünal Akça Gülfer Akça Hasibe Canan Seren Hamit Özyürek |
| author_sort | Mustafa Alper Aykanat |
| collection | DOAJ |
| description | Neonatal seizures are the most prevalent and distinctive sign of neurologic dysfunction in early-life. In spite the recent advances in medical care and technology in newborn intensive care units (NICU), it remains an important clinical issue of diagnosis, treatment, and prognosis. This was a retrospective, observational cohort study of neonates with seizures treated in the Ondokuz Mayıs University Faculty of Medicine NICU. Demographics of the babies, risk factors and etiology of seizure, type of clinical seizure, electroencephalographic and radiological findings, and anti-seizure treatments were recorded. The incidence of neonatal seizures was 4.5% in NICU admissions. Seventy-two babies with seizures included, 69,4% were diagnosed with electroclinical seizures. The most common seizure types were clonic (35.8%) and motor automatisms (32.8%). Perinatal asphyxia/hypoxic ischemic encephalopathy (HIE) (29.2%) was the most common etiological factor, whereas hypoglycemia was the most common metabolic problem (15.3%). Eighty-one percent of seizures due to HIE were observed in the first 48 h. Hyperbilirubinemia (kern icterus), hypocalcemia, and idiopathic neonatal convulsions were observed after the first 48 h. Abnormal findings were detected in 76.4% of electroencephalographies obtained during the neonatal period. Phenobarbital was the first-line therapy in 98.6% of babies, and 83.3% of the infants were seizure-free with phenobarbital. Seizures are common in the neonatal period and may be associated with significant brain damage. Seizures appear as an important symptom of the underlying pathology and not as a disease. |
| first_indexed | 2024-03-08T16:05:25Z |
| format | Article |
| id | doaj.art-56c80566fbb44b8d95e200087a20e104 |
| institution | Directory Open Access Journal |
| issn | 2718-0875 |
| language | English |
| last_indexed | 2024-03-08T16:05:25Z |
| publishDate | 2023-12-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | The Journal of Pediatric Academy |
| spelling | doaj.art-56c80566fbb44b8d95e200087a20e1042024-01-08T06:13:29ZengGalenos Publishing HouseThe Journal of Pediatric Academy2718-08752023-12-014413914510.4274/jpea.2023.247202Clinical and Electrophysiological Evaluation of Neonatal SeizuresMustafa Alper Aykanat0https://orcid.org/0000-0001-6208-7664Ünal Akça1https://orcid.org/0000-0001-5480-1805Gülfer Akça2https://orcid.org/0000-0002-7139-3521Hasibe Canan Seren3https://orcid.org/0000-0002-7955-5943Hamit Özyürek4https://orcid.org/0000-0003-4663-7157Ondokuz Mayıs University Faculty of Medicine, Department of Pediatrics, Samsun, TurkeySamsun University Faculty of Medicine, Department of Pediatric Neurology, Samsun, TurkeySamsun University Faculty of Medicine, Department of Pediatrics, Samsun, TurkeyOndokuz Mayıs University Faculty of Medicine, Department of Neonatology, Samsun, TurkeyOndokuz Mayıs University Faculty of Medicine, Department of Pediatric Neurology, Samsun, TurkeyNeonatal seizures are the most prevalent and distinctive sign of neurologic dysfunction in early-life. In spite the recent advances in medical care and technology in newborn intensive care units (NICU), it remains an important clinical issue of diagnosis, treatment, and prognosis. This was a retrospective, observational cohort study of neonates with seizures treated in the Ondokuz Mayıs University Faculty of Medicine NICU. Demographics of the babies, risk factors and etiology of seizure, type of clinical seizure, electroencephalographic and radiological findings, and anti-seizure treatments were recorded. The incidence of neonatal seizures was 4.5% in NICU admissions. Seventy-two babies with seizures included, 69,4% were diagnosed with electroclinical seizures. The most common seizure types were clonic (35.8%) and motor automatisms (32.8%). Perinatal asphyxia/hypoxic ischemic encephalopathy (HIE) (29.2%) was the most common etiological factor, whereas hypoglycemia was the most common metabolic problem (15.3%). Eighty-one percent of seizures due to HIE were observed in the first 48 h. Hyperbilirubinemia (kern icterus), hypocalcemia, and idiopathic neonatal convulsions were observed after the first 48 h. Abnormal findings were detected in 76.4% of electroencephalographies obtained during the neonatal period. Phenobarbital was the first-line therapy in 98.6% of babies, and 83.3% of the infants were seizure-free with phenobarbital. Seizures are common in the neonatal period and may be associated with significant brain damage. Seizures appear as an important symptom of the underlying pathology and not as a disease.https://jpediatricacademy.com/index.php/jpa/article/view/247neonatal seizureselectroencephalographymotor automatismperinatal asphyxiaphenobarbital |
| spellingShingle | Mustafa Alper Aykanat Ünal Akça Gülfer Akça Hasibe Canan Seren Hamit Özyürek Clinical and Electrophysiological Evaluation of Neonatal Seizures The Journal of Pediatric Academy neonatal seizures electroencephalography motor automatism perinatal asphyxia phenobarbital |
| title | Clinical and Electrophysiological Evaluation of Neonatal Seizures |
| title_full | Clinical and Electrophysiological Evaluation of Neonatal Seizures |
| title_fullStr | Clinical and Electrophysiological Evaluation of Neonatal Seizures |
| title_full_unstemmed | Clinical and Electrophysiological Evaluation of Neonatal Seizures |
| title_short | Clinical and Electrophysiological Evaluation of Neonatal Seizures |
| title_sort | clinical and electrophysiological evaluation of neonatal seizures |
| topic | neonatal seizures electroencephalography motor automatism perinatal asphyxia phenobarbital |
| url | https://jpediatricacademy.com/index.php/jpa/article/view/247 |
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