Fraxetin attenuates disrupted behavioral and central neurochemical activity in a model of chronic unpredictable stress

Fraxetin attenuates disrupted behavioral and central neurochemical activity in a model of chronic unpredictable stress

Purpose: Chronic unpredictable stress (CUS) induces long-term neuronal and synaptic plasticity with a neurohormonal disbalance leading to the development of co-existing anxiety, depression, and cognitive decline. The side effects and delayed onset of current clinically used antidepressants has promp...

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Bibliographic Details
Main Authors:	Zainab Ahmed, Ahmed Tokhi, Mehreen Arif, Naeem Ur Rehman, Vahid Sheibani, Khalid Rauf, Robert D. E. Sewell
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-03-01
Series:	Frontiers in Pharmacology
Subjects:	fraxetin chronic unpredictable stress ELISA corticosterone HPLC
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1135497/full

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