Dendritic Cells Pulsed with Cytokine-Adjuvanted Tumor Membrane Vesicles Inhibit Tumor Growth in HER2-Positive and Triple Negative Breast Cancer Models

Dendritic Cells Pulsed with Cytokine-Adjuvanted Tumor Membrane Vesicles Inhibit Tumor Growth in HER2-Positive and Triple Negative Breast Cancer Models

Dendritic cells (DCs) are the most effective antigen presenting cells for the development of T cell responses. The only FDA approved DC-based immunotherapy to date is Sipuleucel-T, which utilizes a fusion protein to stimulate DCs ex vivo with GM-CSF and simultaneously deliver the antigen PAP for pro...

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Bibliographic Details
Main Authors: Luis E. Munoz, Lenore Monterroza, Ramireddy Bommireddy, Yalda Shafizadeh, Christopher D. Pack, Sampath Ramachandiran, Shaker J. C. Reddy, Periasamy Selvaraj
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
immunotherapy
vaccine
breast cancer
dendritic cells
HER2
GPI-IL-12
Online Access:https://www.mdpi.com/1422-0067/22/16/8377

Internet

https://www.mdpi.com/1422-0067/22/16/8377

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