Design, synthesis, and biological evaluation of novel derivatives of dithiodiglycolic acid prepared via oxidative coupling of thiols

Design, synthesis, and biological evaluation of novel derivatives of dithiodiglycolic acid prepared via oxidative coupling of thiols

Human thioredoxin reductase 1 (TrxR1) is a selenocysteine-containing enzyme which plays a crucial role in regulating numerous redox signalling pathways within the cell. While its functioning is important in all cells, levels of TrxR1 expression are higher in cancer cells, possibly as an adaptation t...

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Bibliographic Details
Main Authors: Olga Bakulina, Anton Bannykh, Mirna Jovanović, Ilona Domračeva, Ana Podolski-Renić, Raivis Žalubovskis, Milica Pešić, Dmitry Dar’in, Mikhail Krasavin
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
trxr
disulphide inhibitors
dithiodiglycolic acid
anticancer activity
Online Access:http://dx.doi.org/10.1080/14756366.2019.1575372

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