High tumor amplification burden is associated with TP53 mutations in the pan-cancer setting
Next-generation sequencing data is fundamentally changing the clinical management of patients with cancer. The most frequent genomic alterations in malignancy are mutations and amplifications, with a subset of tumors having multiple amplifications – “amplificators”. We sought to understand the molec...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Cancer Biology & Therapy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15384047.2022.2128608 |
| _version_ | 1827595123790184448 |
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| author | Rushikesh S. Joshi Amelie Boichard Jacob J. Adashek Razelle Kurzrock |
| author_facet | Rushikesh S. Joshi Amelie Boichard Jacob J. Adashek Razelle Kurzrock |
| author_sort | Rushikesh S. Joshi |
| collection | DOAJ |
| description | Next-generation sequencing data is fundamentally changing the clinical management of patients with cancer. The most frequent genomic alterations in malignancy are mutations and amplifications, with a subset of tumors having multiple amplifications – “amplificators”. We sought to understand the molecular correlates of high tumor amplification burden in a pan-cancer context. Using both national registries and a single-institution dataset, our results demonstrate that cancers with TP53 mutations (as compared to those with wild-type TP53) exhibited significantly higher tumor amplification burden across all datasets. Amplifications, generally associated with overexpression, may be potentially actionable secondary consequences of TP53 mutations. |
| first_indexed | 2024-03-09T02:47:17Z |
| format | Article |
| id | doaj.art-56cd5d1096b14a908af6891a13a48c19 |
| institution | Directory Open Access Journal |
| issn | 1538-4047 1555-8576 |
| language | English |
| last_indexed | 2024-03-09T02:47:17Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cancer Biology & Therapy |
| spelling | doaj.art-56cd5d1096b14a908af6891a13a48c192023-12-05T15:58:14ZengTaylor & Francis GroupCancer Biology & Therapy1538-40471555-85762022-12-012311610.1080/15384047.2022.21286082128608High tumor amplification burden is associated with TP53 mutations in the pan-cancer settingRushikesh S. Joshi0Amelie Boichard1Jacob J. Adashek2Razelle Kurzrock3University of California San DiegoUniversity of Strasbourg HospitalsThe Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins HospitalMedical College of WisconsinNext-generation sequencing data is fundamentally changing the clinical management of patients with cancer. The most frequent genomic alterations in malignancy are mutations and amplifications, with a subset of tumors having multiple amplifications – “amplificators”. We sought to understand the molecular correlates of high tumor amplification burden in a pan-cancer context. Using both national registries and a single-institution dataset, our results demonstrate that cancers with TP53 mutations (as compared to those with wild-type TP53) exhibited significantly higher tumor amplification burden across all datasets. Amplifications, generally associated with overexpression, may be potentially actionable secondary consequences of TP53 mutations.http://dx.doi.org/10.1080/15384047.2022.2128608cancer genesnext-generation sequencingamplificationstp53 |
| spellingShingle | Rushikesh S. Joshi Amelie Boichard Jacob J. Adashek Razelle Kurzrock High tumor amplification burden is associated with TP53 mutations in the pan-cancer setting Cancer Biology & Therapy cancer genes next-generation sequencing amplifications tp53 |
| title | High tumor amplification burden is associated with TP53 mutations in the pan-cancer setting |
| title_full | High tumor amplification burden is associated with TP53 mutations in the pan-cancer setting |
| title_fullStr | High tumor amplification burden is associated with TP53 mutations in the pan-cancer setting |
| title_full_unstemmed | High tumor amplification burden is associated with TP53 mutations in the pan-cancer setting |
| title_short | High tumor amplification burden is associated with TP53 mutations in the pan-cancer setting |
| title_sort | high tumor amplification burden is associated with tp53 mutations in the pan cancer setting |
| topic | cancer genes next-generation sequencing amplifications tp53 |
| url | http://dx.doi.org/10.1080/15384047.2022.2128608 |
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