Efficacy of D-Dimer Assay in Pulmonary Venous Thromboembolism: Study of 76 Cases
Introduction: Venous Thromboembolism (VTE) encompasses a wide spectrum consisting predominantly of deep venous thrombosis and pulmonary embolism. The value of Fibrin Degradation Product (FDP) of which, most common is D-dimer which is most commonly deployed to pre-diagnose venous thrombosis. Diag...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2021-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/14486/47331_CE[Ra]_F(Sh)_PF1(ShG_KM)_PFA(ShG_KM)_GC(SL)_PN(SHU).pdf |
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| author | Shubhi Saxena Nishant Saxena Richa Jain Jasmin Jasani |
| author_facet | Shubhi Saxena Nishant Saxena Richa Jain Jasmin Jasani |
| author_sort | Shubhi Saxena |
| collection | DOAJ |
| description | Introduction: Venous Thromboembolism (VTE) encompasses a
wide spectrum consisting predominantly of deep venous thrombosis
and pulmonary embolism. The value of Fibrin Degradation Product
(FDP) of which, most common is D-dimer which is most commonly
deployed to pre-diagnose venous thrombosis. Diagnosing it
has always been a hard effort. It is produced when cross-linked
fibrin is broken down; among patient who is suspected of having
pulmonary embolism, blood D-dimer levels correlate with the
probability of having pulmonary embolism.
Aim: This study was done to analyse the sensitivity of plasma
D-dimer for VTE.
Materials and Methods: Retrospective case study of 76 patients
with VTE in form of pulmonary embolism done at the Dhiraj
Hospital, Sumandeep Vidyapeeth Deemed University, Vadodara
from January 2019 to January 2020 for a period of one year.
Prethrombolytic plasma was withdrawn and D-dimer quantification
were measured using fully automatic stago coagulometer
instruement (STA Compact Max). Sensitivity, Specificity, Negative
Predictive Value (NPV) and Positive Predictive Value (PPV) was
calculated and formulated in tables and graphs.
Results: The sensitivity, NPV, specificity and PPV of the D-dimer
was 95.65%, 76.92%, 66.66% and 92.95%, respectively. CT
pulmonary angiography had a specificity of 80%, sensitivity of
92.75%, a NPV of 70.58% and a PPV of 95.52%.
Conclusion: D-dimer is mostly the go to test for ruling out
VTE especially pulmonary embolism, if the pre-test probability
is intermediate. Rationale use of this test does help in
prognostification and helps to achieve therapeutics faster and
more effectively. |
| first_indexed | 2024-12-14T20:19:27Z |
| format | Article |
| id | doaj.art-56cdd5554ae54b90bdc24ae2fb0774a6 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-14T20:19:27Z |
| publishDate | 2021-02-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-56cdd5554ae54b90bdc24ae2fb0774a62022-12-21T22:48:47ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2021-02-01152EC01EC0210.7860/JCDR/2021/47331.14486Efficacy of D-Dimer Assay in Pulmonary Venous Thromboembolism: Study of 76 CasesShubhi Saxena0 Nishant Saxena1Richa Jain2Jasmin Jasani3Assistant Professor, Department of Pathology, Smt. BK Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India.Senior Resident, Department of Cardiology, Smt. BK Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India.Assistant Professor, Department of Pathology, Smt. BK Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India.Professor, Department of Pathology, Smt. BK Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India.Introduction: Venous Thromboembolism (VTE) encompasses a wide spectrum consisting predominantly of deep venous thrombosis and pulmonary embolism. The value of Fibrin Degradation Product (FDP) of which, most common is D-dimer which is most commonly deployed to pre-diagnose venous thrombosis. Diagnosing it has always been a hard effort. It is produced when cross-linked fibrin is broken down; among patient who is suspected of having pulmonary embolism, blood D-dimer levels correlate with the probability of having pulmonary embolism. Aim: This study was done to analyse the sensitivity of plasma D-dimer for VTE. Materials and Methods: Retrospective case study of 76 patients with VTE in form of pulmonary embolism done at the Dhiraj Hospital, Sumandeep Vidyapeeth Deemed University, Vadodara from January 2019 to January 2020 for a period of one year. Prethrombolytic plasma was withdrawn and D-dimer quantification were measured using fully automatic stago coagulometer instruement (STA Compact Max). Sensitivity, Specificity, Negative Predictive Value (NPV) and Positive Predictive Value (PPV) was calculated and formulated in tables and graphs. Results: The sensitivity, NPV, specificity and PPV of the D-dimer was 95.65%, 76.92%, 66.66% and 92.95%, respectively. CT pulmonary angiography had a specificity of 80%, sensitivity of 92.75%, a NPV of 70.58% and a PPV of 95.52%. Conclusion: D-dimer is mostly the go to test for ruling out VTE especially pulmonary embolism, if the pre-test probability is intermediate. Rationale use of this test does help in prognostification and helps to achieve therapeutics faster and more effectively.https://www.jcdr.net/articles/PDF/14486/47331_CE[Ra]_F(Sh)_PF1(ShG_KM)_PFA(ShG_KM)_GC(SL)_PN(SHU).pdfdeep venous thrombosispulmonary angiographypulmonary embolism |
| spellingShingle | Shubhi Saxena Nishant Saxena Richa Jain Jasmin Jasani Efficacy of D-Dimer Assay in Pulmonary Venous Thromboembolism: Study of 76 Cases Journal of Clinical and Diagnostic Research deep venous thrombosis pulmonary angiography pulmonary embolism |
| title | Efficacy of D-Dimer Assay in Pulmonary Venous Thromboembolism: Study of 76 Cases |
| title_full | Efficacy of D-Dimer Assay in Pulmonary Venous Thromboembolism: Study of 76 Cases |
| title_fullStr | Efficacy of D-Dimer Assay in Pulmonary Venous Thromboembolism: Study of 76 Cases |
| title_full_unstemmed | Efficacy of D-Dimer Assay in Pulmonary Venous Thromboembolism: Study of 76 Cases |
| title_short | Efficacy of D-Dimer Assay in Pulmonary Venous Thromboembolism: Study of 76 Cases |
| title_sort | efficacy of d dimer assay in pulmonary venous thromboembolism study of 76 cases |
| topic | deep venous thrombosis pulmonary angiography pulmonary embolism |
| url | https://www.jcdr.net/articles/PDF/14486/47331_CE[Ra]_F(Sh)_PF1(ShG_KM)_PFA(ShG_KM)_GC(SL)_PN(SHU).pdf |
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