The S/S Genotype of the 5-HTTLPR (Serotonin-Transporter-Linked Promoter Region) Variant of the SLC6A4 Gene Decreases the Risk of Pre-Eclampsia
Pre-eclampsia (PE) is a disorder characterized by hypertension in the second trimester of pregnancy that results from abnormal placentation affecting fetal development and maternal health. Previous studies have shown the role of serotonin (5-HT) that leads to poor placental perfusion, where S/S and...
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MDPI AG
2023-10-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/11/1535 |
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| author | Rebeca Mónica Ramírez-Armas Idalia Garza-Veloz Juan Carlos Olivas-Chávez Rosa Martha Covarrubias-Carrillo Maria Calixta Martínez-Vázquez Joel Monárrez-Espino Anayantzin E. Ayala-Haro Claudia Vanessa Serrano-Amaya Ivan Delgado-Enciso Iram Pablo Rodriguez-Sanchez Margarita L. Martinez-Fierro |
| author_facet | Rebeca Mónica Ramírez-Armas Idalia Garza-Veloz Juan Carlos Olivas-Chávez Rosa Martha Covarrubias-Carrillo Maria Calixta Martínez-Vázquez Joel Monárrez-Espino Anayantzin E. Ayala-Haro Claudia Vanessa Serrano-Amaya Ivan Delgado-Enciso Iram Pablo Rodriguez-Sanchez Margarita L. Martinez-Fierro |
| author_sort | Rebeca Mónica Ramírez-Armas |
| collection | DOAJ |
| description | Pre-eclampsia (PE) is a disorder characterized by hypertension in the second trimester of pregnancy that results from abnormal placentation affecting fetal development and maternal health. Previous studies have shown the role of serotonin (5-HT) that leads to poor placental perfusion, where S/S and S/L polymorphisms promote the solute carrier family 6 member 4 (SLC6A4) gene associated with the risk of developing changes in the microvasculature of the placenta. This study looked at the association between the gene variant 5-HTTLPR (serotonin-transporter-linked promoter region) of the SLC6A4 gene and the occurrence of PE. A total of 200 women were included: 100 cases (pregnant with PE) and 100 controls (pregnant without complications). Genotyping of the 5-HTTLPR variant was performed using polymerase chain reaction (PCR). Associations between the presence of the genetic variant of interest and PE and other clinical features were evaluated statistically. The frequencies of S/S, S/L, and L/L genotypes were 32%, 53%, and 15% for the cases and 55%, 25%, and 20% in the control group. Compared to the controls, the genotype frequencies S/S vs. S/L + L/L (recessive model) in the cases group were different (<i>p</i> = 0.002). The S/S genotype decreased the probability of PE (OR = 0.39, 95% IC: 0.22–0.69, <i>p</i> = 0.002) and PE with severity criteria (OR = 0.39, 95% IC: 0.17–0.91, <i>p</i> = 0.045). The 5-HTTLPR gene variant of the SLC6A4 gene modifies the risk of PE development among the studied population. |
| first_indexed | 2024-03-09T16:41:01Z |
| format | Article |
| id | doaj.art-56ce821ad55f46d099b62089fd97efeb |
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| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T16:41:01Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-56ce821ad55f46d099b62089fd97efeb2023-11-24T14:51:18ZengMDPI AGJournal of Personalized Medicine2075-44262023-10-011311153510.3390/jpm13111535The S/S Genotype of the 5-HTTLPR (Serotonin-Transporter-Linked Promoter Region) Variant of the SLC6A4 Gene Decreases the Risk of Pre-EclampsiaRebeca Mónica Ramírez-Armas0Idalia Garza-Veloz1Juan Carlos Olivas-Chávez2Rosa Martha Covarrubias-Carrillo3Maria Calixta Martínez-Vázquez4Joel Monárrez-Espino5Anayantzin E. Ayala-Haro6Claudia Vanessa Serrano-Amaya7Ivan Delgado-Enciso8Iram Pablo Rodriguez-Sanchez9Margarita L. Martinez-Fierro10Molecular Medicine Laboratory, Academic Unit of Human and Health Sciences, Autonomous University of Zacatecas, Zacatecas 98160, MexicoMolecular Medicine Laboratory, Academic Unit of Human and Health Sciences, Autonomous University of Zacatecas, Zacatecas 98160, MexicoHospital de la Mujer Zacatecana, Servicios de Salud de Zacatecas, Zacatecas 98600, MexicoMolecular Medicine Laboratory, Academic Unit of Human and Health Sciences, Autonomous University of Zacatecas, Zacatecas 98160, MexicoMolecular Medicine Laboratory, Academic Unit of Human and Health Sciences, Autonomous University of Zacatecas, Zacatecas 98160, MexicoMolecular Medicine Laboratory, Academic Unit of Human and Health Sciences, Autonomous University of Zacatecas, Zacatecas 98160, MexicoMolecular Medicine Laboratory, Academic Unit of Human and Health Sciences, Autonomous University of Zacatecas, Zacatecas 98160, MexicoMolecular Medicine Laboratory, Academic Unit of Human and Health Sciences, Autonomous University of Zacatecas, Zacatecas 98160, MexicoSchool of Medicine, University of Colima, Colima 28040, MexicoLaboratorio de Fisiología Molecular y Estructural, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolás de los Garza 66455, MexicoMolecular Medicine Laboratory, Academic Unit of Human and Health Sciences, Autonomous University of Zacatecas, Zacatecas 98160, MexicoPre-eclampsia (PE) is a disorder characterized by hypertension in the second trimester of pregnancy that results from abnormal placentation affecting fetal development and maternal health. Previous studies have shown the role of serotonin (5-HT) that leads to poor placental perfusion, where S/S and S/L polymorphisms promote the solute carrier family 6 member 4 (SLC6A4) gene associated with the risk of developing changes in the microvasculature of the placenta. This study looked at the association between the gene variant 5-HTTLPR (serotonin-transporter-linked promoter region) of the SLC6A4 gene and the occurrence of PE. A total of 200 women were included: 100 cases (pregnant with PE) and 100 controls (pregnant without complications). Genotyping of the 5-HTTLPR variant was performed using polymerase chain reaction (PCR). Associations between the presence of the genetic variant of interest and PE and other clinical features were evaluated statistically. The frequencies of S/S, S/L, and L/L genotypes were 32%, 53%, and 15% for the cases and 55%, 25%, and 20% in the control group. Compared to the controls, the genotype frequencies S/S vs. S/L + L/L (recessive model) in the cases group were different (<i>p</i> = 0.002). The S/S genotype decreased the probability of PE (OR = 0.39, 95% IC: 0.22–0.69, <i>p</i> = 0.002) and PE with severity criteria (OR = 0.39, 95% IC: 0.17–0.91, <i>p</i> = 0.045). The 5-HTTLPR gene variant of the SLC6A4 gene modifies the risk of PE development among the studied population.https://www.mdpi.com/2075-4426/13/11/1535pre-eclampsiaserotonin5-HTTLPRSLC6A4 gene |
| spellingShingle | Rebeca Mónica Ramírez-Armas Idalia Garza-Veloz Juan Carlos Olivas-Chávez Rosa Martha Covarrubias-Carrillo Maria Calixta Martínez-Vázquez Joel Monárrez-Espino Anayantzin E. Ayala-Haro Claudia Vanessa Serrano-Amaya Ivan Delgado-Enciso Iram Pablo Rodriguez-Sanchez Margarita L. Martinez-Fierro The S/S Genotype of the 5-HTTLPR (Serotonin-Transporter-Linked Promoter Region) Variant of the SLC6A4 Gene Decreases the Risk of Pre-Eclampsia Journal of Personalized Medicine pre-eclampsia serotonin 5-HTTLPR SLC6A4 gene |
| title | The S/S Genotype of the 5-HTTLPR (Serotonin-Transporter-Linked Promoter Region) Variant of the SLC6A4 Gene Decreases the Risk of Pre-Eclampsia |
| title_full | The S/S Genotype of the 5-HTTLPR (Serotonin-Transporter-Linked Promoter Region) Variant of the SLC6A4 Gene Decreases the Risk of Pre-Eclampsia |
| title_fullStr | The S/S Genotype of the 5-HTTLPR (Serotonin-Transporter-Linked Promoter Region) Variant of the SLC6A4 Gene Decreases the Risk of Pre-Eclampsia |
| title_full_unstemmed | The S/S Genotype of the 5-HTTLPR (Serotonin-Transporter-Linked Promoter Region) Variant of the SLC6A4 Gene Decreases the Risk of Pre-Eclampsia |
| title_short | The S/S Genotype of the 5-HTTLPR (Serotonin-Transporter-Linked Promoter Region) Variant of the SLC6A4 Gene Decreases the Risk of Pre-Eclampsia |
| title_sort | s s genotype of the 5 httlpr serotonin transporter linked promoter region variant of the slc6a4 gene decreases the risk of pre eclampsia |
| topic | pre-eclampsia serotonin 5-HTTLPR SLC6A4 gene |
| url | https://www.mdpi.com/2075-4426/13/11/1535 |
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