The Executive Functioning Paradox in Substance Use Disorders
Deficits in neurocognitive functioning are trait-like vulnerabilities that have been widely studied in persons with substance use disorders (SUD), but their role in the craving–use association and relapse vulnerability remains poorly understood. The main objectives of this study were to examine whet...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/11/2728 |
| _version_ | 1797468990233116672 |
|---|---|
| author | Louise Jakubiec Valentine Chirokoff Majd Abdallah Ernesto Sanz-Arigita Maud Dupuy Joel Swendsen Sylvie Berthoz Fabien Gierski Sarah Guionnet David Misdrahi Fuschia Serre Marc Auriacombe Melina Fatseas |
| author_facet | Louise Jakubiec Valentine Chirokoff Majd Abdallah Ernesto Sanz-Arigita Maud Dupuy Joel Swendsen Sylvie Berthoz Fabien Gierski Sarah Guionnet David Misdrahi Fuschia Serre Marc Auriacombe Melina Fatseas |
| author_sort | Louise Jakubiec |
| collection | DOAJ |
| description | Deficits in neurocognitive functioning are trait-like vulnerabilities that have been widely studied in persons with substance use disorders (SUD), but their role in the craving–use association and relapse vulnerability remains poorly understood. The main objectives of this study were to examine whether executive capacities moderate the magnitude of the craving–substance use relationship, and if this influence is correlated with the functional connectivity of cerebral networks, combining rsfMRI examinations and ecological momentary assessment (EMA). Eighty-six patients beginning outpatient treatment for alcohol, tobacco or cannabis addiction and 40 healthy controls completed neuropsychological tests followed by EMA to collect real-time data on craving. Fifty-four patients and 30 healthy controls also completed a resting-state fMRI before the EMA. Among the patients with SUD, better verbal fluency and resistance to interference capacities were associated with a greater propensity to use substances when the individual was experiencing craving. Preliminary rsfMRI results identified specific networks that interacted with executive performance capacities to influence the magnitude of the craving–use association. Individuals with better executive functioning may be more prone to relapse after craving episodes. Specifically, better resistance to interference and cognitive flexibility skills may reduce attention to distracting stimuli, leading to a greater awareness of craving and susceptibility to use substances. |
| first_indexed | 2024-03-09T19:15:07Z |
| format | Article |
| id | doaj.art-56cf6a16b1d24f218f9701ba3a06a1e5 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T19:15:07Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-56cf6a16b1d24f218f9701ba3a06a1e52023-11-24T03:49:43ZengMDPI AGBiomedicines2227-90592022-10-011011272810.3390/biomedicines10112728The Executive Functioning Paradox in Substance Use DisordersLouise Jakubiec0Valentine Chirokoff1Majd Abdallah2Ernesto Sanz-Arigita3Maud Dupuy4Joel Swendsen5Sylvie Berthoz6Fabien Gierski7Sarah Guionnet8David Misdrahi9Fuschia Serre10Marc Auriacombe11Melina Fatseas12University of Bordeaux, CNRS, INCIA, UMR 5287, 33000 Bordeaux, FranceUniversity of Bordeaux, CNRS, INCIA, UMR 5287, EPHE PSL Research University, 33000 Bordeaux, FranceParietal Team, INRIA Saclay Ile-de-France, 91120 Palaiseau, FranceUniversity of Bordeaux, CNRS, INCIA, UMR 5287, 33000 Bordeaux, FranceUniversity of Bordeaux, CNRS, INCIA, UMR 5287, 33000 Bordeaux, FranceUniversity of Bordeaux, CNRS, INCIA, UMR 5287, EPHE PSL Research University, 33000 Bordeaux, FranceUniversity of Bordeaux, CNRS, INCIA, UMR 5287, 33000 Bordeaux, FranceLaboratoire Cognition, Santé et Société, University of Reims Champagne Ardenne, 51571 Reims, FranceUniversity of Bordeaux, CNRS, INCIA, UMR 5287, 33000 Bordeaux, FranceUniversity of Bordeaux, CNRS, INCIA, UMR 5287, 33000 Bordeaux, FranceUniversity of Bordeaux, CNRS, SANPSY, UMR 6033, 33000 Bordeaux, FranceDepartment of Addictology, CH Charles Perrens, 33000 Bordeaux, FranceUniversity of Bordeaux, CNRS, INCIA, UMR 5287, 33000 Bordeaux, FranceDeficits in neurocognitive functioning are trait-like vulnerabilities that have been widely studied in persons with substance use disorders (SUD), but their role in the craving–use association and relapse vulnerability remains poorly understood. The main objectives of this study were to examine whether executive capacities moderate the magnitude of the craving–substance use relationship, and if this influence is correlated with the functional connectivity of cerebral networks, combining rsfMRI examinations and ecological momentary assessment (EMA). Eighty-six patients beginning outpatient treatment for alcohol, tobacco or cannabis addiction and 40 healthy controls completed neuropsychological tests followed by EMA to collect real-time data on craving. Fifty-four patients and 30 healthy controls also completed a resting-state fMRI before the EMA. Among the patients with SUD, better verbal fluency and resistance to interference capacities were associated with a greater propensity to use substances when the individual was experiencing craving. Preliminary rsfMRI results identified specific networks that interacted with executive performance capacities to influence the magnitude of the craving–use association. Individuals with better executive functioning may be more prone to relapse after craving episodes. Specifically, better resistance to interference and cognitive flexibility skills may reduce attention to distracting stimuli, leading to a greater awareness of craving and susceptibility to use substances.https://www.mdpi.com/2227-9059/10/11/2728ecological momentary assessmentsubstance use disordersexecutive functionscravingrsfMRIresting state |
| spellingShingle | Louise Jakubiec Valentine Chirokoff Majd Abdallah Ernesto Sanz-Arigita Maud Dupuy Joel Swendsen Sylvie Berthoz Fabien Gierski Sarah Guionnet David Misdrahi Fuschia Serre Marc Auriacombe Melina Fatseas The Executive Functioning Paradox in Substance Use Disorders Biomedicines ecological momentary assessment substance use disorders executive functions craving rsfMRI resting state |
| title | The Executive Functioning Paradox in Substance Use Disorders |
| title_full | The Executive Functioning Paradox in Substance Use Disorders |
| title_fullStr | The Executive Functioning Paradox in Substance Use Disorders |
| title_full_unstemmed | The Executive Functioning Paradox in Substance Use Disorders |
| title_short | The Executive Functioning Paradox in Substance Use Disorders |
| title_sort | executive functioning paradox in substance use disorders |
| topic | ecological momentary assessment substance use disorders executive functions craving rsfMRI resting state |
| url | https://www.mdpi.com/2227-9059/10/11/2728 |
| work_keys_str_mv | AT louisejakubiec theexecutivefunctioningparadoxinsubstanceusedisorders AT valentinechirokoff theexecutivefunctioningparadoxinsubstanceusedisorders AT majdabdallah theexecutivefunctioningparadoxinsubstanceusedisorders AT ernestosanzarigita theexecutivefunctioningparadoxinsubstanceusedisorders AT mauddupuy theexecutivefunctioningparadoxinsubstanceusedisorders AT joelswendsen theexecutivefunctioningparadoxinsubstanceusedisorders AT sylvieberthoz theexecutivefunctioningparadoxinsubstanceusedisorders AT fabiengierski theexecutivefunctioningparadoxinsubstanceusedisorders AT sarahguionnet theexecutivefunctioningparadoxinsubstanceusedisorders AT davidmisdrahi theexecutivefunctioningparadoxinsubstanceusedisorders AT fuschiaserre theexecutivefunctioningparadoxinsubstanceusedisorders AT marcauriacombe theexecutivefunctioningparadoxinsubstanceusedisorders AT melinafatseas theexecutivefunctioningparadoxinsubstanceusedisorders AT louisejakubiec executivefunctioningparadoxinsubstanceusedisorders AT valentinechirokoff executivefunctioningparadoxinsubstanceusedisorders AT majdabdallah executivefunctioningparadoxinsubstanceusedisorders AT ernestosanzarigita executivefunctioningparadoxinsubstanceusedisorders AT mauddupuy executivefunctioningparadoxinsubstanceusedisorders AT joelswendsen executivefunctioningparadoxinsubstanceusedisorders AT sylvieberthoz executivefunctioningparadoxinsubstanceusedisorders AT fabiengierski executivefunctioningparadoxinsubstanceusedisorders AT sarahguionnet executivefunctioningparadoxinsubstanceusedisorders AT davidmisdrahi executivefunctioningparadoxinsubstanceusedisorders AT fuschiaserre executivefunctioningparadoxinsubstanceusedisorders AT marcauriacombe executivefunctioningparadoxinsubstanceusedisorders AT melinafatseas executivefunctioningparadoxinsubstanceusedisorders |