Somatic structural variation signatures in pediatric brain tumors
Summary: Brain cancer is the leading cause of cancer-related death in children. Somatic structural variations (SVs), large-scale alterations in DNA, remain poorly understood in pediatric brain tumors. Here, we detect a total of 13,199 high-confidence somatic SVs in 744 whole-genome sequences of pedi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723012883 |
| _version_ | 1797657882479558656 |
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| author | Yang Yang Lixing Yang |
| author_facet | Yang Yang Lixing Yang |
| author_sort | Yang Yang |
| collection | DOAJ |
| description | Summary: Brain cancer is the leading cause of cancer-related death in children. Somatic structural variations (SVs), large-scale alterations in DNA, remain poorly understood in pediatric brain tumors. Here, we detect a total of 13,199 high-confidence somatic SVs in 744 whole-genome sequences of pediatric brain tumors from the Pediatric Brain Tumor Atlas. The somatic SV occurrences have tremendous diversity among the cohort and across different tumor types. We decompose mutational signatures of clustered complex SVs, non-clustered complex SVs, and simple SVs separately to infer their mutational mechanisms. Our finding of many tumor types carrying unique sets of SV signatures suggests that distinct molecular mechanisms shape genome instability in different tumor types. The patterns of somatic SV signatures in pediatric brain tumors are substantially different from those in adult cancers. The convergence of multiple SV signatures on several major cancer driver genes implies vital roles of somatic SVs in disease progression. |
| first_indexed | 2024-03-11T17:50:55Z |
| format | Article |
| id | doaj.art-56d2ded8ff7740b09eaa7ea2125a8e08 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-11T17:50:55Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-56d2ded8ff7740b09eaa7ea2125a8e082023-10-18T04:30:59ZengElsevierCell Reports2211-12472023-10-014210113276Somatic structural variation signatures in pediatric brain tumorsYang Yang0Lixing Yang1Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USABen May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA; Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA; University of Chicago Comprehensive Cancer Center, Chicago, IL 60637, USA; Corresponding authorSummary: Brain cancer is the leading cause of cancer-related death in children. Somatic structural variations (SVs), large-scale alterations in DNA, remain poorly understood in pediatric brain tumors. Here, we detect a total of 13,199 high-confidence somatic SVs in 744 whole-genome sequences of pediatric brain tumors from the Pediatric Brain Tumor Atlas. The somatic SV occurrences have tremendous diversity among the cohort and across different tumor types. We decompose mutational signatures of clustered complex SVs, non-clustered complex SVs, and simple SVs separately to infer their mutational mechanisms. Our finding of many tumor types carrying unique sets of SV signatures suggests that distinct molecular mechanisms shape genome instability in different tumor types. The patterns of somatic SV signatures in pediatric brain tumors are substantially different from those in adult cancers. The convergence of multiple SV signatures on several major cancer driver genes implies vital roles of somatic SVs in disease progression.http://www.sciencedirect.com/science/article/pii/S2211124723012883CP: Cancer |
| spellingShingle | Yang Yang Lixing Yang Somatic structural variation signatures in pediatric brain tumors Cell Reports CP: Cancer |
| title | Somatic structural variation signatures in pediatric brain tumors |
| title_full | Somatic structural variation signatures in pediatric brain tumors |
| title_fullStr | Somatic structural variation signatures in pediatric brain tumors |
| title_full_unstemmed | Somatic structural variation signatures in pediatric brain tumors |
| title_short | Somatic structural variation signatures in pediatric brain tumors |
| title_sort | somatic structural variation signatures in pediatric brain tumors |
| topic | CP: Cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723012883 |
| work_keys_str_mv | AT yangyang somaticstructuralvariationsignaturesinpediatricbraintumors AT lixingyang somaticstructuralvariationsignaturesinpediatricbraintumors |