MicroRNA-deficient mouse embryonic stem cells acquire a functional interferon response

MicroRNA-deficient mouse embryonic stem cells acquire a functional interferon response

When mammalian cells detect a viral infection, they initiate a type I interferon (IFNs) response as part of their innate immune system. This antiviral mechanism is conserved in virtually all cell types, except for embryonic stem cells (ESCs) and oocytes which are intrinsically incapable of producing...

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Bibliographic Details
Main Authors: Jeroen Witteveldt, Lisanne I Knol, Sara Macias
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
miRNA
antiviral
interferon
microprocessor
dicer
mavs
Online Access:https://elifesciences.org/articles/44171

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