Recovery of neurosurgical high-frequency electroporation injury in the canine brain can be accelerated by 7,8-dihydroxyflavone
Background: Although traumatic brain injury (TBI) occurs in a very short time, the biological consequence of a TBI, such as Alzheimer’s disease, may last a lifetime. To date, effective interventions are not available to improve recovery from a TBI. Herein we aimed to ascertain whether recovery of ne...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223001609 |
| _version_ | 1797894731450023936 |
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| author | Gang Sun Cheng-Hsien Lin Guiping Mei Jia Gu Sheng-Fang Fan Xiaohong Liu Ruoxu Liu Xun-Wei Liu Xiao-Sen Chen Cheng Zhou Xueqing Yi Peng Jin Ching-Ping Chang Xiao-Jing Lin |
| author_facet | Gang Sun Cheng-Hsien Lin Guiping Mei Jia Gu Sheng-Fang Fan Xiaohong Liu Ruoxu Liu Xun-Wei Liu Xiao-Sen Chen Cheng Zhou Xueqing Yi Peng Jin Ching-Ping Chang Xiao-Jing Lin |
| author_sort | Gang Sun |
| collection | DOAJ |
| description | Background: Although traumatic brain injury (TBI) occurs in a very short time, the biological consequence of a TBI, such as Alzheimer’s disease, may last a lifetime. To date, effective interventions are not available to improve recovery from a TBI. Herein we aimed to ascertain whether recovery of neurosurgical high-frequency irreversible electroporation (HFIRE) injury in brain tissues can be accelerated by 7,8-dihydroxyflavone (7,8-DHF). Methods: The HFIRE injury was induced in the right parietal cortex of 8 adult healthy and neurologically intact male dogs. Two weeks before HFIRE injury, each dog was administered orally with or without 7,8-DHF (30 mg/kg) once daily for consecutive 2 weeks (n = 4 for each group). The values of blood-brain barrier (BBB) disruption, brain edema, and cerebral infarction volumes were measured. The concentrations of beta-amyloid, interleukin-1β, interleukin-6 and tumor necrosis factor-α in the cerebrospinal fluid were measured biochemically. Results: The BBB disruption, brain edema, infarction volumes, and maximal cross-section area caused by HFIRE injury in canine brain were significantly attenuated by 7,8-DHF therapy (P < 0.0001). Additionally, 7,8-DHF significantly reduced the HFIRE-induced cerebral overproduction of beta-amyloid and proinflammatory cytokines in the cerebrospinal fluid (P < 0.0001) in dogs with HFIRE. Conclusions: Recovery of neurosurgical HFIRE injury in canine brain tissues can be accelerated by 7,8-DHT via ameliorating BBB disruption as well as cerebral overproduction of both beta-amyloid and proinflammatory cytokines. |
| first_indexed | 2024-04-10T07:13:58Z |
| format | Article |
| id | doaj.art-56d46a56418243529d0876d95dd4e5e3 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-10T07:13:58Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-56d46a56418243529d0876d95dd4e5e32023-02-26T04:26:37ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-04-01160114372Recovery of neurosurgical high-frequency electroporation injury in the canine brain can be accelerated by 7,8-dihydroxyflavoneGang Sun0Cheng-Hsien Lin1Guiping Mei2Jia Gu3Sheng-Fang Fan4Xiaohong Liu5Ruoxu Liu6Xun-Wei Liu7Xiao-Sen Chen8Cheng Zhou9Xueqing Yi10Peng Jin11Ching-Ping Chang12Xiao-Jing Lin13Department of Medical Imaging, The 960th Hospital of Joint Logistics Support Force of PLA, Shandong Province, P.R. China; Key Laboratory of Military Medical Psychology and Stress Biology of PLA, Shandong Province, P.R. China; Correspondence to: Department of Medical Imaging, The 960th Hospital of Joint Logistics Support Force of PLA, and Key Laboratory of Military Medical Psychology and Stress Biology of PLA, Shandong Province, P.R. China.Department of Medicine, Mackay Medical College, New Taipei, Taiwan; Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan; Correspondence to: Department of Medicine, Mackay Medical College, and Department of Medical Research, Chi Mei Medical Center, Taiwan.Guangzhou Huaxia Vocational College, Guangdong Province, P.R. ChinaSuzhou Powersite Electric Co., Ltd, Jiangsu Province, P.R. ChinaSuzhou Powersite Electric Co., Ltd, Jiangsu Province, P.R. ChinaDepartment of Pathology, The 960th Hospital of Joint Logistics Support Force of PLA, Shandong Province, P.R. ChinaInstitute of Military Cognition and Brain Sciences, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing, P.R. ChinaDepartment of Medical Imaging, The 960th Hospital of Joint Logistics Support Force of PLA, Shandong Province, P.R. ChinaDepartment of Pathology, The 960th Hospital of Joint Logistics Support Force of PLA, Shandong Province, P.R. ChinaDepartment of Pathology, The 960th Hospital of Joint Logistics Support Force of PLA, Shandong Province, P.R. ChinaDepartment of Medical Imaging, The 960th Hospital of Joint Logistics Support Force of PLA, Shandong Province, P.R. ChinaDepartment of Medical Imaging, The 960th Hospital of Joint Logistics Support Force of PLA, Shandong Province, P.R. ChinaDepartment of Medical Research, Chi Mei Medical Center, Tainan, Taiwan; Correspondence to: Department of Medicine, Mackay Medical College, and Department of Medical Research, Chi Mei Medical Center, Taiwan.Department of Medical Imaging, The 960th Hospital of Joint Logistics Support Force of PLA, Shandong Province, P.R. China; Key Laboratory of Military Medical Psychology and Stress Biology of PLA, Shandong Province, P.R. China; Correspondence to: Department of Medical Imaging, The 960th Hospital of Joint Logistics Support Force of PLA, and Key Laboratory of Military Medical Psychology and Stress Biology of PLA, Shandong Province, P.R. China.Background: Although traumatic brain injury (TBI) occurs in a very short time, the biological consequence of a TBI, such as Alzheimer’s disease, may last a lifetime. To date, effective interventions are not available to improve recovery from a TBI. Herein we aimed to ascertain whether recovery of neurosurgical high-frequency irreversible electroporation (HFIRE) injury in brain tissues can be accelerated by 7,8-dihydroxyflavone (7,8-DHF). Methods: The HFIRE injury was induced in the right parietal cortex of 8 adult healthy and neurologically intact male dogs. Two weeks before HFIRE injury, each dog was administered orally with or without 7,8-DHF (30 mg/kg) once daily for consecutive 2 weeks (n = 4 for each group). The values of blood-brain barrier (BBB) disruption, brain edema, and cerebral infarction volumes were measured. The concentrations of beta-amyloid, interleukin-1β, interleukin-6 and tumor necrosis factor-α in the cerebrospinal fluid were measured biochemically. Results: The BBB disruption, brain edema, infarction volumes, and maximal cross-section area caused by HFIRE injury in canine brain were significantly attenuated by 7,8-DHF therapy (P < 0.0001). Additionally, 7,8-DHF significantly reduced the HFIRE-induced cerebral overproduction of beta-amyloid and proinflammatory cytokines in the cerebrospinal fluid (P < 0.0001) in dogs with HFIRE. Conclusions: Recovery of neurosurgical HFIRE injury in canine brain tissues can be accelerated by 7,8-DHT via ameliorating BBB disruption as well as cerebral overproduction of both beta-amyloid and proinflammatory cytokines.http://www.sciencedirect.com/science/article/pii/S0753332223001609High-frequency irreversible electroporationBlood-brain barrierBrain edema7,8-dihydroxyflavoneProinflammatory cytokines |
| spellingShingle | Gang Sun Cheng-Hsien Lin Guiping Mei Jia Gu Sheng-Fang Fan Xiaohong Liu Ruoxu Liu Xun-Wei Liu Xiao-Sen Chen Cheng Zhou Xueqing Yi Peng Jin Ching-Ping Chang Xiao-Jing Lin Recovery of neurosurgical high-frequency electroporation injury in the canine brain can be accelerated by 7,8-dihydroxyflavone Biomedicine & Pharmacotherapy High-frequency irreversible electroporation Blood-brain barrier Brain edema 7,8-dihydroxyflavone Proinflammatory cytokines |
| title | Recovery of neurosurgical high-frequency electroporation injury in the canine brain can be accelerated by 7,8-dihydroxyflavone |
| title_full | Recovery of neurosurgical high-frequency electroporation injury in the canine brain can be accelerated by 7,8-dihydroxyflavone |
| title_fullStr | Recovery of neurosurgical high-frequency electroporation injury in the canine brain can be accelerated by 7,8-dihydroxyflavone |
| title_full_unstemmed | Recovery of neurosurgical high-frequency electroporation injury in the canine brain can be accelerated by 7,8-dihydroxyflavone |
| title_short | Recovery of neurosurgical high-frequency electroporation injury in the canine brain can be accelerated by 7,8-dihydroxyflavone |
| title_sort | recovery of neurosurgical high frequency electroporation injury in the canine brain can be accelerated by 7 8 dihydroxyflavone |
| topic | High-frequency irreversible electroporation Blood-brain barrier Brain edema 7,8-dihydroxyflavone Proinflammatory cytokines |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223001609 |
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