<italic toggle="yes">Leishmania</italic> Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification

<italic toggle="yes">Leishmania</italic> Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification

ABSTRACT Protozoan parasites of the genus Leishmania adapt to environmental change through chromosome and gene copy number variations. Only little is known about external or intrinsic factors that govern Leishmania genomic adaptation. Here, by conducting longitudinal genome analyses of 10 new Leishm...

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Main Authors: Giovanni Bussotti, Evi Gouzelou, Mariana Côrtes Boité, Ihcen Kherachi, Zoubir Harrat, Naouel Eddaikra, Jeremy C. Mottram, Maria Antoniou, Vasiliki Christodoulou, Aymen Bali, Fatma Z. Guerfali, Dhafer Laouini, Maowia Mukhtar, Franck Dumetz, Jean-Claude Dujardin, Despina Smirlis, Pierre Lechat, Pascale Pescher, Adil El Hamouchi, Meryem Lemrani, Carmen Chicharro, Ivonne Pamela Llanes-Acevedo, Laura Botana, Israel Cruz, Javier Moreno, Fakhri Jeddi, Karim Aoun, Aïda Bouratbine, Elisa Cupolillo, Gerald F. Späth
Format: Article
Language:English
Published: American Society for Microbiology 2018-12-01
Series:mBio
Subjects:
Leishmania
aneuploidy
evolution
gene copy number variation
genomic adaptation
telomeric amplification
Online Access:https://journals.asm.org/doi/10.1128/mBio.01399-18

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