| Summary: | The seeds of Clausena lansium have been used to treat acute and chronic gastro-intestinal disorders. To further explore its therapeutic value on metabolic diseases, a water soluble fraction from ethanolic extract of C. lansium seeds (HP) was evaluated on a high-fat diet (HFD) induced obesity mice model. The mice were fed with HFD for 8 weeks to induce obesity, and then orally administrated with HP for 9 weeks. The results showed HP treatment retarded body weight and fat mass gain of mice under HFD feeding. Moreover, HP significantly improved lipid profile and insulin sensitivity in HFD fed mice. 16S rRNA sequencing indicated that HP mildly reversed HFD feeding induced imbalance of Firmicutes/Bacteroidetes ratio in gut. Taken together, HP protects mice from HFD induced metabolic disorders and restores gut microbiota balance, which might be well developed as novel functional food for anti-obesity and improvement of insulin sensitivity.
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