Water soluble fraction from ethanolic extract of Clausena lansium seeds alleviates obesity and insulin resistance, and changes the composition of gut microbiota in high-fat diet-fed mice
The seeds of Clausena lansium have been used to treat acute and chronic gastro-intestinal disorders. To further explore its therapeutic value on metabolic diseases, a water soluble fraction from ethanolic extract of C. lansium seeds (HP) was evaluated on a high-fat diet (HFD) induced obesity mice mo...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-08-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464618302755 |
| _version_ | 1819020798336172032 |
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| author | Shengnan Shen Qiwen Liao Li Huang Dan Li Qingwen Zhang Yitao Wang Simon Ming-Yuen Lee Ligen Lin |
| author_facet | Shengnan Shen Qiwen Liao Li Huang Dan Li Qingwen Zhang Yitao Wang Simon Ming-Yuen Lee Ligen Lin |
| author_sort | Shengnan Shen |
| collection | DOAJ |
| description | The seeds of Clausena lansium have been used to treat acute and chronic gastro-intestinal disorders. To further explore its therapeutic value on metabolic diseases, a water soluble fraction from ethanolic extract of C. lansium seeds (HP) was evaluated on a high-fat diet (HFD) induced obesity mice model. The mice were fed with HFD for 8 weeks to induce obesity, and then orally administrated with HP for 9 weeks. The results showed HP treatment retarded body weight and fat mass gain of mice under HFD feeding. Moreover, HP significantly improved lipid profile and insulin sensitivity in HFD fed mice. 16S rRNA sequencing indicated that HP mildly reversed HFD feeding induced imbalance of Firmicutes/Bacteroidetes ratio in gut. Taken together, HP protects mice from HFD induced metabolic disorders and restores gut microbiota balance, which might be well developed as novel functional food for anti-obesity and improvement of insulin sensitivity. |
| first_indexed | 2024-12-21T03:56:56Z |
| format | Article |
| id | doaj.art-56d9be72e14a4b798db8670bf2613fab |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-21T03:56:56Z |
| publishDate | 2018-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-56d9be72e14a4b798db8670bf2613fab2022-12-21T19:16:48ZengElsevierJournal of Functional Foods1756-46462018-08-0147192199Water soluble fraction from ethanolic extract of Clausena lansium seeds alleviates obesity and insulin resistance, and changes the composition of gut microbiota in high-fat diet-fed miceShengnan Shen0Qiwen Liao1Li Huang2Dan Li3Qingwen Zhang4Yitao Wang5Simon Ming-Yuen Lee6Ligen Lin7State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, ChinaCorresponding author at: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa 999078, Macau, China.; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, ChinaThe seeds of Clausena lansium have been used to treat acute and chronic gastro-intestinal disorders. To further explore its therapeutic value on metabolic diseases, a water soluble fraction from ethanolic extract of C. lansium seeds (HP) was evaluated on a high-fat diet (HFD) induced obesity mice model. The mice were fed with HFD for 8 weeks to induce obesity, and then orally administrated with HP for 9 weeks. The results showed HP treatment retarded body weight and fat mass gain of mice under HFD feeding. Moreover, HP significantly improved lipid profile and insulin sensitivity in HFD fed mice. 16S rRNA sequencing indicated that HP mildly reversed HFD feeding induced imbalance of Firmicutes/Bacteroidetes ratio in gut. Taken together, HP protects mice from HFD induced metabolic disorders and restores gut microbiota balance, which might be well developed as novel functional food for anti-obesity and improvement of insulin sensitivity.http://www.sciencedirect.com/science/article/pii/S1756464618302755Clausena lansiumFat mass gainInsulin sensitivityGut microbiotaWampee |
| spellingShingle | Shengnan Shen Qiwen Liao Li Huang Dan Li Qingwen Zhang Yitao Wang Simon Ming-Yuen Lee Ligen Lin Water soluble fraction from ethanolic extract of Clausena lansium seeds alleviates obesity and insulin resistance, and changes the composition of gut microbiota in high-fat diet-fed mice Journal of Functional Foods Clausena lansium Fat mass gain Insulin sensitivity Gut microbiota Wampee |
| title | Water soluble fraction from ethanolic extract of Clausena lansium seeds alleviates obesity and insulin resistance, and changes the composition of gut microbiota in high-fat diet-fed mice |
| title_full | Water soluble fraction from ethanolic extract of Clausena lansium seeds alleviates obesity and insulin resistance, and changes the composition of gut microbiota in high-fat diet-fed mice |
| title_fullStr | Water soluble fraction from ethanolic extract of Clausena lansium seeds alleviates obesity and insulin resistance, and changes the composition of gut microbiota in high-fat diet-fed mice |
| title_full_unstemmed | Water soluble fraction from ethanolic extract of Clausena lansium seeds alleviates obesity and insulin resistance, and changes the composition of gut microbiota in high-fat diet-fed mice |
| title_short | Water soluble fraction from ethanolic extract of Clausena lansium seeds alleviates obesity and insulin resistance, and changes the composition of gut microbiota in high-fat diet-fed mice |
| title_sort | water soluble fraction from ethanolic extract of clausena lansium seeds alleviates obesity and insulin resistance and changes the composition of gut microbiota in high fat diet fed mice |
| topic | Clausena lansium Fat mass gain Insulin sensitivity Gut microbiota Wampee |
| url | http://www.sciencedirect.com/science/article/pii/S1756464618302755 |
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