Modulation of Ca2+ Signaling by Anti-apoptotic B-Cell Lymphoma 2 Proteins at the Endoplasmic Reticulum–Mitochondrial Interface

Modulation of Ca2+ Signaling by Anti-apoptotic B-Cell Lymphoma 2 Proteins at the Endoplasmic Reticulum–Mitochondrial Interface

Mitochondria are important regulators of cell death and cell survival. Mitochondrial Ca2+ levels are critically involved in both of these processes. On the one hand, excessive mitochondrial Ca2+ leads to Ca2+-induced mitochondrial outer membrane permeabilization and thus apoptosis. On the other hand...

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Bibliographic Details
Main Authors: Tim Vervliet, Eva Clerix, Bruno Seitaj, Hristina Ivanova, Giovanni Monaco, Geert Bultynck
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Oncology
Subjects:
endoplasmic reticulum–mitochondria contact sites
Ca2+-transport systems
apoptosis
autophagy
mitochondrial bio energetics
IP3 receptors
Online Access:http://journal.frontiersin.org/article/10.3389/fonc.2017.00075/full

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