Advances in Diagnosis and Therapy for Bladder Cancer
Bladder cancer (BCa) is one of the most common and expensive urinary system malignancies for its high recurrence and progression rate. In recent years, immense amounts of studies have been carried out to bring a more comprehensive cognition and numerous promising clinic approaches for BCa therapy. T...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/13/3181 |
| _version_ | 1797480673702838272 |
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| author | Xinzi Hu Guangzhi Li Song Wu |
| author_facet | Xinzi Hu Guangzhi Li Song Wu |
| author_sort | Xinzi Hu |
| collection | DOAJ |
| description | Bladder cancer (BCa) is one of the most common and expensive urinary system malignancies for its high recurrence and progression rate. In recent years, immense amounts of studies have been carried out to bring a more comprehensive cognition and numerous promising clinic approaches for BCa therapy. The development of innovative enhanced cystoscopy techniques (optical techniques, imaging systems) and tumor biomarkers-based non-invasive urine screening (DNA methylation-based urine test) would dramatically improve the accuracy of tumor detection, reducing the risk of recurrence and progression of BCa. Moreover, intravesical instillation and systemic therapeutic strategies (cocktail therapy, immunotherapy, vaccine therapy, targeted therapy) also provide plentiful measures to break the predicament of BCa. Several exploratory clinical studies, including novel surgical approaches, pharmaceutical compositions, and bladder preservation techniques, emerged continually, which are supposed to be promising candidates for BCa clinical treatment. Here, recent advances and prospects of diagnosis, intravesical or systemic treatment, and novel drug delivery systems for BCa therapy are reviewed in this paper. |
| first_indexed | 2024-03-09T22:03:26Z |
| format | Article |
| id | doaj.art-56de836affa84b94a85b7540b9f46c0c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T22:03:26Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-56de836affa84b94a85b7540b9f46c0c2023-11-23T19:45:45ZengMDPI AGCancers2072-66942022-06-011413318110.3390/cancers14133181Advances in Diagnosis and Therapy for Bladder CancerXinzi Hu0Guangzhi Li1Song Wu2Institute of Urology, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen University, Shenzhen 518000, ChinaInstitute of Urology, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen University, Shenzhen 518000, ChinaInstitute of Urology, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen University, Shenzhen 518000, ChinaBladder cancer (BCa) is one of the most common and expensive urinary system malignancies for its high recurrence and progression rate. In recent years, immense amounts of studies have been carried out to bring a more comprehensive cognition and numerous promising clinic approaches for BCa therapy. The development of innovative enhanced cystoscopy techniques (optical techniques, imaging systems) and tumor biomarkers-based non-invasive urine screening (DNA methylation-based urine test) would dramatically improve the accuracy of tumor detection, reducing the risk of recurrence and progression of BCa. Moreover, intravesical instillation and systemic therapeutic strategies (cocktail therapy, immunotherapy, vaccine therapy, targeted therapy) also provide plentiful measures to break the predicament of BCa. Several exploratory clinical studies, including novel surgical approaches, pharmaceutical compositions, and bladder preservation techniques, emerged continually, which are supposed to be promising candidates for BCa clinical treatment. Here, recent advances and prospects of diagnosis, intravesical or systemic treatment, and novel drug delivery systems for BCa therapy are reviewed in this paper.https://www.mdpi.com/2072-6694/14/13/3181bladder cancerdiagnosisnon-invasive urine screeningintravesical or systemic therapyliquid biopsy |
| spellingShingle | Xinzi Hu Guangzhi Li Song Wu Advances in Diagnosis and Therapy for Bladder Cancer Cancers bladder cancer diagnosis non-invasive urine screening intravesical or systemic therapy liquid biopsy |
| title | Advances in Diagnosis and Therapy for Bladder Cancer |
| title_full | Advances in Diagnosis and Therapy for Bladder Cancer |
| title_fullStr | Advances in Diagnosis and Therapy for Bladder Cancer |
| title_full_unstemmed | Advances in Diagnosis and Therapy for Bladder Cancer |
| title_short | Advances in Diagnosis and Therapy for Bladder Cancer |
| title_sort | advances in diagnosis and therapy for bladder cancer |
| topic | bladder cancer diagnosis non-invasive urine screening intravesical or systemic therapy liquid biopsy |
| url | https://www.mdpi.com/2072-6694/14/13/3181 |
| work_keys_str_mv | AT xinzihu advancesindiagnosisandtherapyforbladdercancer AT guangzhili advancesindiagnosisandtherapyforbladdercancer AT songwu advancesindiagnosisandtherapyforbladdercancer |