Low Serum Adiponectin Levels in Children and Adolescents with Diabetic Retinopathy
Objective: The aim of this study was to elucidate the role of adiponectin, leptin, TNF-α and IL-6 on the early detection of the microvascular complications of type I diabetes. Materials and Methods: A total of 88 children were included in the study. There were 60 type I diabetic patients and 28 heal...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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AVES
2011-04-01
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| Series: | Eurasian Journal of Medicine |
| Subjects: | |
| Online Access: | http://www.eajm.org/text.php3?id=378 |
| _version_ | 1797913913395773440 |
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| author | Eser Tasci Mehmet Nuri Ozbek Neslihan Onenli-Mungan Fatih Temiz Ali Kemal Topaloglu Bilgin Yuksel |
| author_facet | Eser Tasci Mehmet Nuri Ozbek Neslihan Onenli-Mungan Fatih Temiz Ali Kemal Topaloglu Bilgin Yuksel |
| author_sort | Eser Tasci |
| collection | DOAJ |
| description | Objective: The aim of this study was to elucidate the role of adiponectin, leptin, TNF-α and IL-6 on the early detection of the microvascular complications of type I diabetes. Materials and Methods: A total of 88 children were included in the study. There were 60 type I diabetic patients and 28 healthy control children. Results: The gender, age, weight, height, BMI and puberty status characteristics were similar in the patient and control groups (p>0.05). The serum leptin, TNF-α and IL-6 levels were similar between the patient and control groups (p>0.05) and the only difference was in the serum adiponectin level which was higher in the patient group (p:0.042). We also found no association between the adiponectin, leptin, TNF-α and IL-6 levels and diabetes duration (p>0.05). Leptin was high in the pubertal period (p:0.016), while adiponectin TNF-α and IL-6 levels were similar in the prepubertal and pubertal periods (p>0.05). The serum leptin level was high in microalbuminuria patients (p<0.041). The serum adiponectin, TNF-α, and IL-6 levels were not different in patients with and without microalbuminuria (p>0.05). The serum adiponectin level was lower in diabetic retinopathy patients (p:0.003), while the serum leptin level was higher (p:0.003). The TNF-α and IL-6 levels were similar in patients with and without retinopathy (p>0.05). Conclusion: We found increased serum adinopectin levels in children and adolescents with type I diabetes mellitus and low levels in diabetic retinopathy patients. Patients with low serum adiponectin levels and high leptin levels should be more closely monitored for chronic complication development and better metabolic control should be aimed for. |
| first_indexed | 2024-04-10T12:18:50Z |
| format | Article |
| id | doaj.art-56df72c190a54e3384e8e312b53eecef |
| institution | Directory Open Access Journal |
| issn | 1308-8734 1308-8742 |
| language | English |
| last_indexed | 2024-04-10T12:18:50Z |
| publishDate | 2011-04-01 |
| publisher | AVES |
| record_format | Article |
| series | Eurasian Journal of Medicine |
| spelling | doaj.art-56df72c190a54e3384e8e312b53eecef2023-02-15T16:15:32ZengAVESEurasian Journal of Medicine1308-87341308-87422011-04-0143011822Low Serum Adiponectin Levels in Children and Adolescents with Diabetic RetinopathyEser TasciMehmet Nuri OzbekNeslihan Onenli-MunganFatih TemizAli Kemal TopalogluBilgin YukselObjective: The aim of this study was to elucidate the role of adiponectin, leptin, TNF-α and IL-6 on the early detection of the microvascular complications of type I diabetes. Materials and Methods: A total of 88 children were included in the study. There were 60 type I diabetic patients and 28 healthy control children. Results: The gender, age, weight, height, BMI and puberty status characteristics were similar in the patient and control groups (p>0.05). The serum leptin, TNF-α and IL-6 levels were similar between the patient and control groups (p>0.05) and the only difference was in the serum adiponectin level which was higher in the patient group (p:0.042). We also found no association between the adiponectin, leptin, TNF-α and IL-6 levels and diabetes duration (p>0.05). Leptin was high in the pubertal period (p:0.016), while adiponectin TNF-α and IL-6 levels were similar in the prepubertal and pubertal periods (p>0.05). The serum leptin level was high in microalbuminuria patients (p<0.041). The serum adiponectin, TNF-α, and IL-6 levels were not different in patients with and without microalbuminuria (p>0.05). The serum adiponectin level was lower in diabetic retinopathy patients (p:0.003), while the serum leptin level was higher (p:0.003). The TNF-α and IL-6 levels were similar in patients with and without retinopathy (p>0.05). Conclusion: We found increased serum adinopectin levels in children and adolescents with type I diabetes mellitus and low levels in diabetic retinopathy patients. Patients with low serum adiponectin levels and high leptin levels should be more closely monitored for chronic complication development and better metabolic control should be aimed for.http://www.eajm.org/text.php3?id=378AdinopectinChildren and AdolescentsLeptinRetinopathyType I Diabetes Mellitus |
| spellingShingle | Eser Tasci Mehmet Nuri Ozbek Neslihan Onenli-Mungan Fatih Temiz Ali Kemal Topaloglu Bilgin Yuksel Low Serum Adiponectin Levels in Children and Adolescents with Diabetic Retinopathy Eurasian Journal of Medicine Adinopectin Children and Adolescents Leptin Retinopathy Type I Diabetes Mellitus |
| title | Low Serum Adiponectin Levels in Children and Adolescents with Diabetic Retinopathy |
| title_full | Low Serum Adiponectin Levels in Children and Adolescents with Diabetic Retinopathy |
| title_fullStr | Low Serum Adiponectin Levels in Children and Adolescents with Diabetic Retinopathy |
| title_full_unstemmed | Low Serum Adiponectin Levels in Children and Adolescents with Diabetic Retinopathy |
| title_short | Low Serum Adiponectin Levels in Children and Adolescents with Diabetic Retinopathy |
| title_sort | low serum adiponectin levels in children and adolescents with diabetic retinopathy |
| topic | Adinopectin Children and Adolescents Leptin Retinopathy Type I Diabetes Mellitus |
| url | http://www.eajm.org/text.php3?id=378 |
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