Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway

Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway

Abstract Background Pyroptosis belongs to a novel inflammatory programmed cell death pathway, with the possible prognosis of endometrial cancer related to the terminal protein GSDMD. Hydrogen exerts a biphasic effect on cancer by promoting tumor cell death and protecting normal cells, which might in...

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Bibliographic Details
Main Authors: Ye Yang, Ping Yin Liu, Wei Bao, Song Jun Chen, Fang Su Wu, Ping Ya Zhu
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Cancer
Subjects:
Hydrogen
Endometrial cancer
Pyroptosis
GSDMD
NLRP3
Online Access:https://doi.org/10.1186/s12885-019-6491-6

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