AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling

AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling

Abstract Adenoid cystic carcinoma (ACC) is an aggressive salivary gland malignancy with limited treatment options for recurrent or metastatic disease. Due to chemotherapy resistance and lack of targeted therapeutic approaches, current treatment options for the localized disease are limited to surger...

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Bibliographic Details
Main Authors: Renata Ferrarotto, Vasudha Mishra, Elad Herz, Adar Yaacov, Oz Solomon, Rami Rauch, Adi Mondshine, Maria Motin, Tal Leibovich-Rivkin, Matti Davis, Joel Kaye, Christopher R. Weber, Le Shen, Alexander T. Pearson, Ari J. Rosenberg, Xiangying Chen, Alka Singh, Jon C. Aster, Nishant Agrawal, Evgeny Izumchenko
Format: Article
Language:English
Published: Nature Publishing Group 2022-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05133-9

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