Capsaicin ameliorate pulmonary fibrosis via antioxidant Nrf-2/ PPAR- γ pathway activation and inflammatory TGF-β1/ NF-κB/COX II pathway inhibition

Capsaicin ameliorate pulmonary fibrosis via antioxidant Nrf-2/ PPAR- γ pathway activation and inflammatory TGF-β1/ NF-κB/COX II pathway inhibition

Bleomycin is an effective antibiotic with a significant anticancer properties, but its use is limited due to its potential to induce dose-dependent pulmonary fibrosis. Therefore, this study aimed to assess the therapeutic potential of Capsaicin as an additional treatment to enhance patient tolerance...

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Bibliographic Details
Main Authors: Wesam H. Abdulaal, Hani Z. Asfour, Nawal Helmi, Hadeel Al Sadoun, Basmah Eldakhakhny, Nabil A. Alhakamy, Hani Mohammed Alqarni, Saeed Ali Mohammed Alzahrani, Mohamed A. El-Moselhy, Sara S. Sharkawi, Esam Mohamed Aboubakr
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Pharmacology
Subjects:
Capsaicin
bleomycin
Pirfenidone
pulmonary fibrosis
TGF-β1
PPAR-γ
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1333715/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1333715/full

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