Si-based agent alleviated small bowel ischemia–reperfusion injury through antioxidant effects

Abstract The progression of small bowel ischemia–reperfusion (IR) injury causes cells in the intestinal tract to undergo necrosis, necessitating surgical resection, which may result in loss of intestinal function. Therefore, developing therapeutic agents that can prevent IR injury at early stages an...

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Main Authors: Masato Shimada, Yoshihisa Koyama, Yuki Kobayashi, Yasunari Matsumoto, Hikaru Kobayashi, Shoichi Shimada
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-54542-7
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author Masato Shimada
Yoshihisa Koyama
Yuki Kobayashi
Yasunari Matsumoto
Hikaru Kobayashi
Shoichi Shimada
author_facet Masato Shimada
Yoshihisa Koyama
Yuki Kobayashi
Yasunari Matsumoto
Hikaru Kobayashi
Shoichi Shimada
author_sort Masato Shimada
collection DOAJ
description Abstract The progression of small bowel ischemia–reperfusion (IR) injury causes cells in the intestinal tract to undergo necrosis, necessitating surgical resection, which may result in loss of intestinal function. Therefore, developing therapeutic agents that can prevent IR injury at early stages and suppress its progression is imperative. As IR injury may be closely related to oxidative stress, antioxidants can be effective therapeutic agents. Our silicon (Si)-based agent, an antioxidant, generated a large amount of hydrogen in the intestinal tract for a prolonged period after oral administration. As it has been effective for ulcerative colitis, renal failure, and IR injury during skin flap transplantation, it could be effective for small intestinal IR injury. Herein, we investigated the efficacy of an Si-based agent in a mouse model of small intestinal IR injury. The Si-based agent suppressed the apoptosis of small intestinal epithelial cells by reducing the oxidative stress induced by IR injury. In addition, the thickness of the mucosal layer in the small intestine of the Si-based agent-administered group was significantly higher than that in the untreated group, revealing that Si-based agent is effective against small intestinal IR injuries. In the future, Si-based agents may improve the success rate of small intestine transplantation.
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spelling doaj.art-56e6f774a5754df2a7bb051a88a7fc372024-03-05T19:11:00ZengNature PortfolioScientific Reports2045-23222024-02-0114111210.1038/s41598-024-54542-7Si-based agent alleviated small bowel ischemia–reperfusion injury through antioxidant effectsMasato Shimada0Yoshihisa Koyama1Yuki Kobayashi2Yasunari Matsumoto3Hikaru Kobayashi4Shoichi Shimada5Department of Neuroscience and Cell Biology, Osaka University Graduate School of MedicineDepartment of Neuroscience and Cell Biology, Osaka University Graduate School of MedicineSANKEN, Osaka UniversityDepartment of Neuroscience and Cell Biology, Osaka University Graduate School of MedicineSANKEN, Osaka UniversityDepartment of Neuroscience and Cell Biology, Osaka University Graduate School of MedicineAbstract The progression of small bowel ischemia–reperfusion (IR) injury causes cells in the intestinal tract to undergo necrosis, necessitating surgical resection, which may result in loss of intestinal function. Therefore, developing therapeutic agents that can prevent IR injury at early stages and suppress its progression is imperative. As IR injury may be closely related to oxidative stress, antioxidants can be effective therapeutic agents. Our silicon (Si)-based agent, an antioxidant, generated a large amount of hydrogen in the intestinal tract for a prolonged period after oral administration. As it has been effective for ulcerative colitis, renal failure, and IR injury during skin flap transplantation, it could be effective for small intestinal IR injury. Herein, we investigated the efficacy of an Si-based agent in a mouse model of small intestinal IR injury. The Si-based agent suppressed the apoptosis of small intestinal epithelial cells by reducing the oxidative stress induced by IR injury. In addition, the thickness of the mucosal layer in the small intestine of the Si-based agent-administered group was significantly higher than that in the untreated group, revealing that Si-based agent is effective against small intestinal IR injuries. In the future, Si-based agents may improve the success rate of small intestine transplantation.https://doi.org/10.1038/s41598-024-54542-7
spellingShingle Masato Shimada
Yoshihisa Koyama
Yuki Kobayashi
Yasunari Matsumoto
Hikaru Kobayashi
Shoichi Shimada
Si-based agent alleviated small bowel ischemia–reperfusion injury through antioxidant effects
Scientific Reports
title Si-based agent alleviated small bowel ischemia–reperfusion injury through antioxidant effects
title_full Si-based agent alleviated small bowel ischemia–reperfusion injury through antioxidant effects
title_fullStr Si-based agent alleviated small bowel ischemia–reperfusion injury through antioxidant effects
title_full_unstemmed Si-based agent alleviated small bowel ischemia–reperfusion injury through antioxidant effects
title_short Si-based agent alleviated small bowel ischemia–reperfusion injury through antioxidant effects
title_sort si based agent alleviated small bowel ischemia reperfusion injury through antioxidant effects
url https://doi.org/10.1038/s41598-024-54542-7
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