Si-based agent alleviated small bowel ischemia–reperfusion injury through antioxidant effects
Abstract The progression of small bowel ischemia–reperfusion (IR) injury causes cells in the intestinal tract to undergo necrosis, necessitating surgical resection, which may result in loss of intestinal function. Therefore, developing therapeutic agents that can prevent IR injury at early stages an...
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Language: | English |
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Nature Portfolio
2024-02-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-024-54542-7 |
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author | Masato Shimada Yoshihisa Koyama Yuki Kobayashi Yasunari Matsumoto Hikaru Kobayashi Shoichi Shimada |
author_facet | Masato Shimada Yoshihisa Koyama Yuki Kobayashi Yasunari Matsumoto Hikaru Kobayashi Shoichi Shimada |
author_sort | Masato Shimada |
collection | DOAJ |
description | Abstract The progression of small bowel ischemia–reperfusion (IR) injury causes cells in the intestinal tract to undergo necrosis, necessitating surgical resection, which may result in loss of intestinal function. Therefore, developing therapeutic agents that can prevent IR injury at early stages and suppress its progression is imperative. As IR injury may be closely related to oxidative stress, antioxidants can be effective therapeutic agents. Our silicon (Si)-based agent, an antioxidant, generated a large amount of hydrogen in the intestinal tract for a prolonged period after oral administration. As it has been effective for ulcerative colitis, renal failure, and IR injury during skin flap transplantation, it could be effective for small intestinal IR injury. Herein, we investigated the efficacy of an Si-based agent in a mouse model of small intestinal IR injury. The Si-based agent suppressed the apoptosis of small intestinal epithelial cells by reducing the oxidative stress induced by IR injury. In addition, the thickness of the mucosal layer in the small intestine of the Si-based agent-administered group was significantly higher than that in the untreated group, revealing that Si-based agent is effective against small intestinal IR injuries. In the future, Si-based agents may improve the success rate of small intestine transplantation. |
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id | doaj.art-56e6f774a5754df2a7bb051a88a7fc37 |
institution | Directory Open Access Journal |
issn | 2045-2322 |
language | English |
last_indexed | 2024-03-07T15:00:21Z |
publishDate | 2024-02-01 |
publisher | Nature Portfolio |
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series | Scientific Reports |
spelling | doaj.art-56e6f774a5754df2a7bb051a88a7fc372024-03-05T19:11:00ZengNature PortfolioScientific Reports2045-23222024-02-0114111210.1038/s41598-024-54542-7Si-based agent alleviated small bowel ischemia–reperfusion injury through antioxidant effectsMasato Shimada0Yoshihisa Koyama1Yuki Kobayashi2Yasunari Matsumoto3Hikaru Kobayashi4Shoichi Shimada5Department of Neuroscience and Cell Biology, Osaka University Graduate School of MedicineDepartment of Neuroscience and Cell Biology, Osaka University Graduate School of MedicineSANKEN, Osaka UniversityDepartment of Neuroscience and Cell Biology, Osaka University Graduate School of MedicineSANKEN, Osaka UniversityDepartment of Neuroscience and Cell Biology, Osaka University Graduate School of MedicineAbstract The progression of small bowel ischemia–reperfusion (IR) injury causes cells in the intestinal tract to undergo necrosis, necessitating surgical resection, which may result in loss of intestinal function. Therefore, developing therapeutic agents that can prevent IR injury at early stages and suppress its progression is imperative. As IR injury may be closely related to oxidative stress, antioxidants can be effective therapeutic agents. Our silicon (Si)-based agent, an antioxidant, generated a large amount of hydrogen in the intestinal tract for a prolonged period after oral administration. As it has been effective for ulcerative colitis, renal failure, and IR injury during skin flap transplantation, it could be effective for small intestinal IR injury. Herein, we investigated the efficacy of an Si-based agent in a mouse model of small intestinal IR injury. The Si-based agent suppressed the apoptosis of small intestinal epithelial cells by reducing the oxidative stress induced by IR injury. In addition, the thickness of the mucosal layer in the small intestine of the Si-based agent-administered group was significantly higher than that in the untreated group, revealing that Si-based agent is effective against small intestinal IR injuries. In the future, Si-based agents may improve the success rate of small intestine transplantation.https://doi.org/10.1038/s41598-024-54542-7 |
spellingShingle | Masato Shimada Yoshihisa Koyama Yuki Kobayashi Yasunari Matsumoto Hikaru Kobayashi Shoichi Shimada Si-based agent alleviated small bowel ischemia–reperfusion injury through antioxidant effects Scientific Reports |
title | Si-based agent alleviated small bowel ischemia–reperfusion injury through antioxidant effects |
title_full | Si-based agent alleviated small bowel ischemia–reperfusion injury through antioxidant effects |
title_fullStr | Si-based agent alleviated small bowel ischemia–reperfusion injury through antioxidant effects |
title_full_unstemmed | Si-based agent alleviated small bowel ischemia–reperfusion injury through antioxidant effects |
title_short | Si-based agent alleviated small bowel ischemia–reperfusion injury through antioxidant effects |
title_sort | si based agent alleviated small bowel ischemia reperfusion injury through antioxidant effects |
url | https://doi.org/10.1038/s41598-024-54542-7 |
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