GQDs Incorporated CoPc Nanorods for Electrochemical Detection of Dopamine and Uric Acid

Abstract Dopamine (DA) and uric acid (UA) are biomolecules of great consideration that coexist in human body. It is essential and challenging to detect them simultaneously with high sensitivity. This paper reports a novel electrochemical biosensor based on the nanocomposites of cobalt phthalocyanine...

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Main Authors: Bo Wu, Minzhang Li, Rajendran Ramachandran, Gaoqiang Niu, Mingxiang Zhang, Changhui Zhao, Zongxiang Xu, Fei Wang
Format: Article
Language:English
Published: Wiley-VCH 2023-01-01
Series:Advanced Materials Interfaces
Subjects:
Online Access:https://doi.org/10.1002/admi.202200738
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author Bo Wu
Minzhang Li
Rajendran Ramachandran
Gaoqiang Niu
Mingxiang Zhang
Changhui Zhao
Zongxiang Xu
Fei Wang
author_facet Bo Wu
Minzhang Li
Rajendran Ramachandran
Gaoqiang Niu
Mingxiang Zhang
Changhui Zhao
Zongxiang Xu
Fei Wang
author_sort Bo Wu
collection DOAJ
description Abstract Dopamine (DA) and uric acid (UA) are biomolecules of great consideration that coexist in human body. It is essential and challenging to detect them simultaneously with high sensitivity. This paper reports a novel electrochemical biosensor based on the nanocomposites of cobalt phthalocyanine (CoPc) anchored with graphene quantum dots (GQDs) for DA and UA detection. The GQDs incorporation on CoPc nanorods with partial end stretching significantly enhances the electrocatalytic activity and promotes the electron transfer rate. Low detection limits of 21 nm for DA and 145 nm for UA have been successfully achieved for the fabricated CoPc/GQDs biosensor. The density‐functional theory proves the enhanced conductivity of CoPc/GQDs and the biomolecule's interaction with the electrode surface. Furthermore, the proposed sensor shows remarkable reproducibility, repeatability, and stability. The fabricated sensor is applied for the simultaneous detections of DA and UA in human urine samples. The excellent performance suggests that the CoPc/GQDs could be a promising and potential candidate for electrochemical sensors to detect DA and UA selectively.
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spelling doaj.art-56ec6be2663f4f8b827272e107bf67da2023-07-26T01:40:29ZengWiley-VCHAdvanced Materials Interfaces2196-73502023-01-01101n/an/a10.1002/admi.202200738GQDs Incorporated CoPc Nanorods for Electrochemical Detection of Dopamine and Uric AcidBo Wu0Minzhang Li1Rajendran Ramachandran2Gaoqiang Niu3Mingxiang Zhang4Changhui Zhao5Zongxiang Xu6Fei Wang7School of Microelectronics Southern University of Science and Technology Shenzhen 518055 ChinaDepartment of Chemistry Southern University of Science and Technology Shenzhen 518055 ChinaSchool of Microelectronics Southern University of Science and Technology Shenzhen 518055 ChinaSchool of Microelectronics Southern University of Science and Technology Shenzhen 518055 ChinaSchool of Microelectronics Southern University of Science and Technology Shenzhen 518055 ChinaSchool of Microelectronics Southern University of Science and Technology Shenzhen 518055 ChinaDepartment of Chemistry Southern University of Science and Technology Shenzhen 518055 ChinaSchool of Microelectronics Southern University of Science and Technology Shenzhen 518055 ChinaAbstract Dopamine (DA) and uric acid (UA) are biomolecules of great consideration that coexist in human body. It is essential and challenging to detect them simultaneously with high sensitivity. This paper reports a novel electrochemical biosensor based on the nanocomposites of cobalt phthalocyanine (CoPc) anchored with graphene quantum dots (GQDs) for DA and UA detection. The GQDs incorporation on CoPc nanorods with partial end stretching significantly enhances the electrocatalytic activity and promotes the electron transfer rate. Low detection limits of 21 nm for DA and 145 nm for UA have been successfully achieved for the fabricated CoPc/GQDs biosensor. The density‐functional theory proves the enhanced conductivity of CoPc/GQDs and the biomolecule's interaction with the electrode surface. Furthermore, the proposed sensor shows remarkable reproducibility, repeatability, and stability. The fabricated sensor is applied for the simultaneous detections of DA and UA in human urine samples. The excellent performance suggests that the CoPc/GQDs could be a promising and potential candidate for electrochemical sensors to detect DA and UA selectively.https://doi.org/10.1002/admi.202200738cobalt phthalocyaninedopaminegraphene quantum dotslow detection limituric acid
spellingShingle Bo Wu
Minzhang Li
Rajendran Ramachandran
Gaoqiang Niu
Mingxiang Zhang
Changhui Zhao
Zongxiang Xu
Fei Wang
GQDs Incorporated CoPc Nanorods for Electrochemical Detection of Dopamine and Uric Acid
Advanced Materials Interfaces
cobalt phthalocyanine
dopamine
graphene quantum dots
low detection limit
uric acid
title GQDs Incorporated CoPc Nanorods for Electrochemical Detection of Dopamine and Uric Acid
title_full GQDs Incorporated CoPc Nanorods for Electrochemical Detection of Dopamine and Uric Acid
title_fullStr GQDs Incorporated CoPc Nanorods for Electrochemical Detection of Dopamine and Uric Acid
title_full_unstemmed GQDs Incorporated CoPc Nanorods for Electrochemical Detection of Dopamine and Uric Acid
title_short GQDs Incorporated CoPc Nanorods for Electrochemical Detection of Dopamine and Uric Acid
title_sort gqds incorporated copc nanorods for electrochemical detection of dopamine and uric acid
topic cobalt phthalocyanine
dopamine
graphene quantum dots
low detection limit
uric acid
url https://doi.org/10.1002/admi.202200738
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