Mycobacterium tuberculosis: immune response, biomarkers, and therapeutic intervention
Abstract Although tuberculosis (TB) is an infectious disease, the progression of the disease following Mycobacterium tuberculosis (MTB) infection is closely associated with the host's immune response. In this review, a comprehensive analysis of TB prevention, diagnosis, and treatment was conduc...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
|
| Series: | MedComm |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mco2.419 |
| _version_ | 1797347143612104704 |
|---|---|
| author | Li Zhuang Ling Yang Linsheng Li Zhaoyang Ye Wenping Gong |
| author_facet | Li Zhuang Ling Yang Linsheng Li Zhaoyang Ye Wenping Gong |
| author_sort | Li Zhuang |
| collection | DOAJ |
| description | Abstract Although tuberculosis (TB) is an infectious disease, the progression of the disease following Mycobacterium tuberculosis (MTB) infection is closely associated with the host's immune response. In this review, a comprehensive analysis of TB prevention, diagnosis, and treatment was conducted from an immunological perspective. First, we delved into the host's immune response mechanisms against MTB infection as well as the immune evasion mechanisms of the bacteria. Addressing the challenges currently faced in TB diagnosis and treatment, we also emphasized the importance of protein, genetic, and immunological biomarkers, aiming to provide new insights for early and personalized diagnosis and treatment of TB. Building upon this foundation, we further discussed intervention strategies involving chemical and immunological treatments for the increasingly critical issue of drug‐resistant TB and other forms of TB. Finally, we summarized TB prevention, diagnosis, and treatment challenges and put forward future perspectives. Overall, these findings provide valuable insights into the immunological aspects of TB and offer new directions toward achieving the WHO's goal of eradicating TB by 2035. |
| first_indexed | 2024-03-08T11:43:25Z |
| format | Article |
| id | doaj.art-56ec79917c514935b70295f3406e59e6 |
| institution | Directory Open Access Journal |
| issn | 2688-2663 |
| language | English |
| last_indexed | 2024-03-08T11:43:25Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj.art-56ec79917c514935b70295f3406e59e62024-01-25T02:14:28ZengWileyMedComm2688-26632024-01-0151n/an/a10.1002/mco2.419Mycobacterium tuberculosis: immune response, biomarkers, and therapeutic interventionLi Zhuang0Ling Yang1Linsheng Li2Zhaoyang Ye3Wenping Gong4Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment Senior Department of Tuberculosis, the Eighth Medical Center of PLA General Hospital Beijing ChinaSenior Department of Tuberculosis Hebei North University Zhangjiakou Hebei ChinaSenior Department of Tuberculosis Hebei North University Zhangjiakou Hebei ChinaSenior Department of Tuberculosis Hebei North University Zhangjiakou Hebei ChinaBeijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment Senior Department of Tuberculosis, the Eighth Medical Center of PLA General Hospital Beijing ChinaAbstract Although tuberculosis (TB) is an infectious disease, the progression of the disease following Mycobacterium tuberculosis (MTB) infection is closely associated with the host's immune response. In this review, a comprehensive analysis of TB prevention, diagnosis, and treatment was conducted from an immunological perspective. First, we delved into the host's immune response mechanisms against MTB infection as well as the immune evasion mechanisms of the bacteria. Addressing the challenges currently faced in TB diagnosis and treatment, we also emphasized the importance of protein, genetic, and immunological biomarkers, aiming to provide new insights for early and personalized diagnosis and treatment of TB. Building upon this foundation, we further discussed intervention strategies involving chemical and immunological treatments for the increasingly critical issue of drug‐resistant TB and other forms of TB. Finally, we summarized TB prevention, diagnosis, and treatment challenges and put forward future perspectives. Overall, these findings provide valuable insights into the immunological aspects of TB and offer new directions toward achieving the WHO's goal of eradicating TB by 2035.https://doi.org/10.1002/mco2.419biomarkersdiagnostic methodsimmune checkpointsimmune responsemycobacterium tuberculosis (MTB)therapeutic vaccines |
| spellingShingle | Li Zhuang Ling Yang Linsheng Li Zhaoyang Ye Wenping Gong Mycobacterium tuberculosis: immune response, biomarkers, and therapeutic intervention MedComm biomarkers diagnostic methods immune checkpoints immune response mycobacterium tuberculosis (MTB) therapeutic vaccines |
| title | Mycobacterium tuberculosis: immune response, biomarkers, and therapeutic intervention |
| title_full | Mycobacterium tuberculosis: immune response, biomarkers, and therapeutic intervention |
| title_fullStr | Mycobacterium tuberculosis: immune response, biomarkers, and therapeutic intervention |
| title_full_unstemmed | Mycobacterium tuberculosis: immune response, biomarkers, and therapeutic intervention |
| title_short | Mycobacterium tuberculosis: immune response, biomarkers, and therapeutic intervention |
| title_sort | mycobacterium tuberculosis immune response biomarkers and therapeutic intervention |
| topic | biomarkers diagnostic methods immune checkpoints immune response mycobacterium tuberculosis (MTB) therapeutic vaccines |
| url | https://doi.org/10.1002/mco2.419 |
| work_keys_str_mv | AT lizhuang mycobacteriumtuberculosisimmuneresponsebiomarkersandtherapeuticintervention AT lingyang mycobacteriumtuberculosisimmuneresponsebiomarkersandtherapeuticintervention AT linshengli mycobacteriumtuberculosisimmuneresponsebiomarkersandtherapeuticintervention AT zhaoyangye mycobacteriumtuberculosisimmuneresponsebiomarkersandtherapeuticintervention AT wenpinggong mycobacteriumtuberculosisimmuneresponsebiomarkersandtherapeuticintervention |