Investigation of the dose enhancement effect of spherical bismuth oxide nanoparticles in external beam radiotherapy
Introduction: External radiotherapy is the most common method of radiotherapy which the most important problem associated with is that there is no difference between healthy and tumor tissues in dose absorption. One way to differentiate the dose sensitivity is to use metal-based nanoparticles. Bismu...
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Iranian Society of Nanomedicine
2020-03-01
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| Series: | Nanomedicine Research Journal |
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| Online Access: | http://www.nanomedicine-rj.com/article_38646_97bffc360d092b4ab65eef98d78118c9.pdf |
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| author | Zahra Alyani Nezhad Ghazale Geraily Fatemeh Hataminia Somayeh Gholami Seyed Mohammad Mahdi Abtahi Hossien Ghanbari |
| author_facet | Zahra Alyani Nezhad Ghazale Geraily Fatemeh Hataminia Somayeh Gholami Seyed Mohammad Mahdi Abtahi Hossien Ghanbari |
| author_sort | Zahra Alyani Nezhad |
| collection | DOAJ |
| description | Introduction: External radiotherapy is the most common method of radiotherapy which the most important problem associated with is that there is no difference between healthy and tumor tissues in dose absorption. One way to differentiate the dose sensitivity is to use metal-based nanoparticles. Bismuth oxide nanoparticles are good candidates for cancer radiotherapy. In this study, we investigated the dose enhancement effect of the synthesized spherical Bi2O3 NPs in 6MV external radiotherapy. Material and methods: Bi2O3 were synthesized and GENIPIN gel dosimeter was produced and divided into two equal portions, one part to fill vials containing pure gel and the other part to be added to a specified amount of nanoparticles to give a concentration of 0.1Mm. Then, the irradiation of the pure gel and gel vials containing the NPs was performed one day after manufacture by a 6MV external radiotherapy device. Gel readout was performed using spectrophotometer and absorption-dose curves were achieved. Results: results show that spherical Bi2O3 NPs cause a decrease in GENIPIN absorbance range compared to gel without NPs. The slope of the absorbance-dose curve in presence of NPs is 0.038 which is more than this slop in the pure gel (0.029) which indicates a DEF of 1.31 in the usage of these NPs in the tumor. Conclusion: we can conclude that by applying these spherical Bi2O3 NPs, dose absorption of the tumor will increase up to 31% which means the efficacy of radiotherapy can be maintained by lower applied dose to the tumor and healthy cells. |
| first_indexed | 2024-04-11T16:06:06Z |
| format | Article |
| id | doaj.art-56ec912aa8014b368aebc04eed06d0c8 |
| institution | Directory Open Access Journal |
| issn | 2476-3489 2476-7123 |
| language | English |
| last_indexed | 2024-04-11T16:06:06Z |
| publishDate | 2020-03-01 |
| publisher | Iranian Society of Nanomedicine |
| record_format | Article |
| series | Nanomedicine Research Journal |
| spelling | doaj.art-56ec912aa8014b368aebc04eed06d0c82022-12-22T04:14:49ZengIranian Society of NanomedicineNanomedicine Research Journal2476-34892476-71232020-03-0151556210.22034/nmrj.2020.01.00738646Investigation of the dose enhancement effect of spherical bismuth oxide nanoparticles in external beam radiotherapyZahra Alyani Nezhad0Ghazale Geraily1Fatemeh Hataminia2Somayeh Gholami3Seyed Mohammad Mahdi Abtahi4Hossien Ghanbari5Department of Medical Physics and Medical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Medical Physics and Medical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, IranRadiotherapy Oncology and radiobiology Research Centre, Cancer Institute, Tehran University of Medical Sciences, Tehran, IranDepartment of Physics, Imam Khomeini International University, Qazvin, IranDepartment of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, IranIntroduction: External radiotherapy is the most common method of radiotherapy which the most important problem associated with is that there is no difference between healthy and tumor tissues in dose absorption. One way to differentiate the dose sensitivity is to use metal-based nanoparticles. Bismuth oxide nanoparticles are good candidates for cancer radiotherapy. In this study, we investigated the dose enhancement effect of the synthesized spherical Bi2O3 NPs in 6MV external radiotherapy. Material and methods: Bi2O3 were synthesized and GENIPIN gel dosimeter was produced and divided into two equal portions, one part to fill vials containing pure gel and the other part to be added to a specified amount of nanoparticles to give a concentration of 0.1Mm. Then, the irradiation of the pure gel and gel vials containing the NPs was performed one day after manufacture by a 6MV external radiotherapy device. Gel readout was performed using spectrophotometer and absorption-dose curves were achieved. Results: results show that spherical Bi2O3 NPs cause a decrease in GENIPIN absorbance range compared to gel without NPs. The slope of the absorbance-dose curve in presence of NPs is 0.038 which is more than this slop in the pure gel (0.029) which indicates a DEF of 1.31 in the usage of these NPs in the tumor. Conclusion: we can conclude that by applying these spherical Bi2O3 NPs, dose absorption of the tumor will increase up to 31% which means the efficacy of radiotherapy can be maintained by lower applied dose to the tumor and healthy cells.http://www.nanomedicine-rj.com/article_38646_97bffc360d092b4ab65eef98d78118c9.pdfexternal radiotherapybismuth oxidenanoparticlesdose enhancementgel dosimetrygenipin gel |
| spellingShingle | Zahra Alyani Nezhad Ghazale Geraily Fatemeh Hataminia Somayeh Gholami Seyed Mohammad Mahdi Abtahi Hossien Ghanbari Investigation of the dose enhancement effect of spherical bismuth oxide nanoparticles in external beam radiotherapy Nanomedicine Research Journal external radiotherapy bismuth oxide nanoparticles dose enhancement gel dosimetry genipin gel |
| title | Investigation of the dose enhancement effect of spherical bismuth oxide nanoparticles in external beam radiotherapy |
| title_full | Investigation of the dose enhancement effect of spherical bismuth oxide nanoparticles in external beam radiotherapy |
| title_fullStr | Investigation of the dose enhancement effect of spherical bismuth oxide nanoparticles in external beam radiotherapy |
| title_full_unstemmed | Investigation of the dose enhancement effect of spherical bismuth oxide nanoparticles in external beam radiotherapy |
| title_short | Investigation of the dose enhancement effect of spherical bismuth oxide nanoparticles in external beam radiotherapy |
| title_sort | investigation of the dose enhancement effect of spherical bismuth oxide nanoparticles in external beam radiotherapy |
| topic | external radiotherapy bismuth oxide nanoparticles dose enhancement gel dosimetry genipin gel |
| url | http://www.nanomedicine-rj.com/article_38646_97bffc360d092b4ab65eef98d78118c9.pdf |
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