Platelet large cell ratio (P-LCR) in predicting acute coronary syndromes before aspirin use
Introduction: Platelet large cell ratio (P-LCR) test is one of the test parameters that is routinely calculated in the hemogram test, and expressed as the ratio of platelets with platelet volume greater than 12 fL. Large platelets are relatively younger and contain more intracellular granules, meani...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences Press
2020-09-01
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| Series: | Journal of Research in Clinical Medicine |
| Subjects: | |
| Online Access: | https://jrcm.tbzmed.ac.ir/PDF/jrcm-8-35.pdf |
| _version_ | 1831681631049482240 |
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| author | Erdal Tekin Mustafa Bayraktar Muhammet Celik Ibrahim Ozlu |
| author_facet | Erdal Tekin Mustafa Bayraktar Muhammet Celik Ibrahim Ozlu |
| author_sort | Erdal Tekin |
| collection | DOAJ |
| description | Introduction: Platelet large cell ratio (P-LCR) test is one of the test parameters that is routinely calculated in the hemogram test, and expressed as the ratio of platelets with platelet volume greater than 12 fL. Large platelets are relatively younger and contain more intracellular granules, meaning that platelets have more thrombogenic potential. In the literature investigating the relationship between the acute coronary syndrome and P-LCR levels, the use of aspirin in patients and its effects on platelet parameters were ignored. In our study, for the first time in the literature, the relationship between P-LCR levels and acute coronary syndromes were investigated by means of including the patients before they took aspirin which ensures that P-LCR test is not affected by aspirin. Method: Retrospectively, patients aged 18-70 years were screened and those whose hemogram tests were completed before aspirin usage were included. A total of 109 patients diagnosed with unstable angina (UA), non-ST elevation myocardial infarction (NSTEMI) and ST-elevation myocardial infarction (STEMI) were included and compared in the study. Results: The mean P-LCR values were 23.61% (95% CI: 21.97-25.25) in UA patients, 28.34% (95% CI: 24.86-31.83) in NSTEMI, and 25.71% (95% CI: 22.07-29.35) in STEMI patients. There was a statistically significant difference between the P-LCR values among the groups (p=0.022). Conclusion: The increase in P-LCR, free of aspirin effects, was found to be statistically significant in acute coronary syndromes. |
| first_indexed | 2024-12-20T06:01:36Z |
| format | Article |
| id | doaj.art-56ed233045f1430aa6b42e75975f0649 |
| institution | Directory Open Access Journal |
| issn | 2717-0616 |
| language | English |
| last_indexed | 2024-12-20T06:01:36Z |
| publishDate | 2020-09-01 |
| publisher | Tabriz University of Medical Sciences Press |
| record_format | Article |
| series | Journal of Research in Clinical Medicine |
| spelling | doaj.art-56ed233045f1430aa6b42e75975f06492022-12-21T19:50:54ZengTabriz University of Medical Sciences PressJournal of Research in Clinical Medicine2717-06162020-09-0181353510.34172/jrcm.2020.035jrcm-31858Platelet large cell ratio (P-LCR) in predicting acute coronary syndromes before aspirin useErdal Tekin0Mustafa Bayraktar1Muhammet Celik2Ibrahim Ozlu3Department of Emergency Medicine, Faculty of Medicine, University of Ataturk, Erzurum, TurkeyDepartment of Family Medicine, Faculty of Medicine, University of Ataturk, Erzurum, TurkeyDepartment of Biochemistry, Faculty of Medicine, University of Ataturk, Erzurum, TurkeyDepartment of Emergency Medicine, Faculty of Medicine, University of Ataturk, Erzurum, TurkeyIntroduction: Platelet large cell ratio (P-LCR) test is one of the test parameters that is routinely calculated in the hemogram test, and expressed as the ratio of platelets with platelet volume greater than 12 fL. Large platelets are relatively younger and contain more intracellular granules, meaning that platelets have more thrombogenic potential. In the literature investigating the relationship between the acute coronary syndrome and P-LCR levels, the use of aspirin in patients and its effects on platelet parameters were ignored. In our study, for the first time in the literature, the relationship between P-LCR levels and acute coronary syndromes were investigated by means of including the patients before they took aspirin which ensures that P-LCR test is not affected by aspirin. Method: Retrospectively, patients aged 18-70 years were screened and those whose hemogram tests were completed before aspirin usage were included. A total of 109 patients diagnosed with unstable angina (UA), non-ST elevation myocardial infarction (NSTEMI) and ST-elevation myocardial infarction (STEMI) were included and compared in the study. Results: The mean P-LCR values were 23.61% (95% CI: 21.97-25.25) in UA patients, 28.34% (95% CI: 24.86-31.83) in NSTEMI, and 25.71% (95% CI: 22.07-29.35) in STEMI patients. There was a statistically significant difference between the P-LCR values among the groups (p=0.022). Conclusion: The increase in P-LCR, free of aspirin effects, was found to be statistically significant in acute coronary syndromes.https://jrcm.tbzmed.ac.ir/PDF/jrcm-8-35.pdfplateletl arge cell ratioaspirinst elevated myocardial infarctionnon-st-elevation myocardial infarctionunstable angina |
| spellingShingle | Erdal Tekin Mustafa Bayraktar Muhammet Celik Ibrahim Ozlu Platelet large cell ratio (P-LCR) in predicting acute coronary syndromes before aspirin use Journal of Research in Clinical Medicine plateletl arge cell ratio aspirin st elevated myocardial infarction non-st-elevation myocardial infarction unstable angina |
| title | Platelet large cell ratio (P-LCR) in predicting acute coronary syndromes before aspirin use |
| title_full | Platelet large cell ratio (P-LCR) in predicting acute coronary syndromes before aspirin use |
| title_fullStr | Platelet large cell ratio (P-LCR) in predicting acute coronary syndromes before aspirin use |
| title_full_unstemmed | Platelet large cell ratio (P-LCR) in predicting acute coronary syndromes before aspirin use |
| title_short | Platelet large cell ratio (P-LCR) in predicting acute coronary syndromes before aspirin use |
| title_sort | platelet large cell ratio p lcr in predicting acute coronary syndromes before aspirin use |
| topic | plateletl arge cell ratio aspirin st elevated myocardial infarction non-st-elevation myocardial infarction unstable angina |
| url | https://jrcm.tbzmed.ac.ir/PDF/jrcm-8-35.pdf |
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