Obesity paradox in heart failure patients – Female gender characteristics-KAMC-single center experience
Background/Introduction: The correlation between low body mass index (BMI) and congestive heart failure (obesity paradox) has been described in the literature; However, the association between BMI and clinical outcome measures is not well characterized. Little is known about CHF in the Middle Easter...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2017-09-01
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| Series: | The Egyptian Heart Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S111026081630134X |
| _version_ | 1819017613741654016 |
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| author | Sheeren Khaled Rajaa Matahen |
| author_facet | Sheeren Khaled Rajaa Matahen |
| author_sort | Sheeren Khaled |
| collection | DOAJ |
| description | Background/Introduction: The correlation between low body mass index (BMI) and congestive heart failure (obesity paradox) has been described in the literature; However, the association between BMI and clinical outcome measures is not well characterized. Little is known about CHF in the Middle Eastern female population; most of the gender-specific information on heart failure comes from higher income “Western” countries.
Objectives: We aimed to identify the correlation between heart failure patients especially those with low BMI and clinical/safety outcome measures with focusing on female patients subgroup characteristics.
Methods: We performed group comparisons of statistically relevant variables using prospectively collected data of HFrEF patients hospitalized over a 12 month period.
Results: The 167 patients (Group I) enrolled by this study with mean age of 59.64 ± 12.9 years, an EF score of 23.96 ± 10.14, 62.9% had ischemic etiology, 12.5% were smoker, 18% had AF, 31.1% had received ICD/CRT-D and an estimated 8.85 ± 9.5 days length of stay (LOS). The low BMI group of patients (Group II) had means age of 58.7 ± 14.5 years, a significant lower EF score of 20.32 ± 8.58, significantly higher 30, 90 days readmission rates and in-house mortality (22%, 36.6% and 17.1% vs 10.2%, 20.4% and 6.6% respectively) and higher rates of CVA, TIA and unexplained syncope (19.5% vs 7.2%). Similarly, female patients with low BMI (Group IV) had lower EF score of 22.0 ± 53, higher 30,90 days readmission rates and in-house mortality (34.4%,43.8% and 25% vs 13.5%,21.6% and 5.4% respectively) and higher rates of CVA, TIA and unexplained syncope(10% vs 0%).
Conclusion: Our findings showed that heart failure patients with low BMI had poor adverse clinical outcome measures (poor EF, recurrent readmission, mortality and composite rates of CVA, TIA and unexplained syncope) which reflect the effect of obesity paradox in those patients with HFrEF. Female patient subgroup showed similar characteristic findings which also might reflect the value of gender-specific BMI related clinical outcomes. |
| first_indexed | 2024-12-21T03:06:19Z |
| format | Article |
| id | doaj.art-56edb957f34741cc995dcadf109acc30 |
| institution | Directory Open Access Journal |
| issn | 1110-2608 |
| language | English |
| last_indexed | 2024-12-21T03:06:19Z |
| publishDate | 2017-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Heart Journal |
| spelling | doaj.art-56edb957f34741cc995dcadf109acc302022-12-21T19:18:05ZengSpringerOpenThe Egyptian Heart Journal1110-26082017-09-0169320921310.1016/j.ehj.2017.06.002Obesity paradox in heart failure patients – Female gender characteristics-KAMC-single center experienceSheeren Khaled0Rajaa Matahen1King Abdullah Medical City-Makkah, Muzdallfa Road, Saudi ArabiaKing Abdullah Medical City-Makkah, Muzdallfa Road, Saudi ArabiaBackground/Introduction: The correlation between low body mass index (BMI) and congestive heart failure (obesity paradox) has been described in the literature; However, the association between BMI and clinical outcome measures is not well characterized. Little is known about CHF in the Middle Eastern female population; most of the gender-specific information on heart failure comes from higher income “Western” countries. Objectives: We aimed to identify the correlation between heart failure patients especially those with low BMI and clinical/safety outcome measures with focusing on female patients subgroup characteristics. Methods: We performed group comparisons of statistically relevant variables using prospectively collected data of HFrEF patients hospitalized over a 12 month period. Results: The 167 patients (Group I) enrolled by this study with mean age of 59.64 ± 12.9 years, an EF score of 23.96 ± 10.14, 62.9% had ischemic etiology, 12.5% were smoker, 18% had AF, 31.1% had received ICD/CRT-D and an estimated 8.85 ± 9.5 days length of stay (LOS). The low BMI group of patients (Group II) had means age of 58.7 ± 14.5 years, a significant lower EF score of 20.32 ± 8.58, significantly higher 30, 90 days readmission rates and in-house mortality (22%, 36.6% and 17.1% vs 10.2%, 20.4% and 6.6% respectively) and higher rates of CVA, TIA and unexplained syncope (19.5% vs 7.2%). Similarly, female patients with low BMI (Group IV) had lower EF score of 22.0 ± 53, higher 30,90 days readmission rates and in-house mortality (34.4%,43.8% and 25% vs 13.5%,21.6% and 5.4% respectively) and higher rates of CVA, TIA and unexplained syncope(10% vs 0%). Conclusion: Our findings showed that heart failure patients with low BMI had poor adverse clinical outcome measures (poor EF, recurrent readmission, mortality and composite rates of CVA, TIA and unexplained syncope) which reflect the effect of obesity paradox in those patients with HFrEF. Female patient subgroup showed similar characteristic findings which also might reflect the value of gender-specific BMI related clinical outcomes.http://www.sciencedirect.com/science/article/pii/S111026081630134XObesity paradoxHeart failureFemale gender |
| spellingShingle | Sheeren Khaled Rajaa Matahen Obesity paradox in heart failure patients – Female gender characteristics-KAMC-single center experience The Egyptian Heart Journal Obesity paradox Heart failure Female gender |
| title | Obesity paradox in heart failure patients – Female gender characteristics-KAMC-single center experience |
| title_full | Obesity paradox in heart failure patients – Female gender characteristics-KAMC-single center experience |
| title_fullStr | Obesity paradox in heart failure patients – Female gender characteristics-KAMC-single center experience |
| title_full_unstemmed | Obesity paradox in heart failure patients – Female gender characteristics-KAMC-single center experience |
| title_short | Obesity paradox in heart failure patients – Female gender characteristics-KAMC-single center experience |
| title_sort | obesity paradox in heart failure patients female gender characteristics kamc single center experience |
| topic | Obesity paradox Heart failure Female gender |
| url | http://www.sciencedirect.com/science/article/pii/S111026081630134X |
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